Graphene Quantum Dot Sensitized Heterojunctions Induce Tumor-Specific Cuproptosis to Boost Sonodynamic and Chemodynamic Enhanced Cancer Immunotherapy.

Cuproptosis that utilizes copper ionophore to induce programmed cell death holds promise for enhancing the effectiveness of conventional anticancer therapies and triggering efficient adaptive immune responses. However, the non-tumor-specific release of Cu ions can induce cuproptosis and cause irreversible damage to normal tissues. To maximize the therapeutic effects of tumor-specific cuproptosis, this work reports for the first time the regulation of degradation behaviors of Cu-based nanomaterials using graphene quantum dots (GQDs) as a protection layer.

Tumor Microenvironment Activated Cu Crosslinked Near-Infrared Sonosensitizers for Visualized Cuproptosis-Enhanced Sonodynamic Cancer Immunotherapy.

Reactive oxygen species (ROS)-mediated sonodynamic therapy (SDT) holds increasing potential in treating deep-seated tumor owing to the high tissue-penetration depth. However, the inevitable accumulation of sonosensitizers in normal tissues not only make it difficult to realize the in situ SDT, but also induces sonodynamic effects in normal tissues. Herein, this work reports the passivation and selective activation strategies for the sonodynamic and near-infrared (NIR) imaging performances of an intelligent antitumor theranostic platform termed Cu-IR783 nanoparticles (NPs).

Near-Infrared Carbon Dots With Antibacterial and Osteogenic Activities for Sonodynamic Therapy of Infected Bone Defects.

Repairing infected bone defects is hindered by the presence of stubborn bacterial infections and inadequate osteogenic activity. The incorporation of harmful antibiotics not only fosters the emergence of multidrug-resistant bacteria, but also diminishes the osteogenic properties of scaffold materials. In addition, it is essential to continuously monitor the degradation kinetics of scaffold materials at bone defect sites, yet the majority of bone repair materials lack imaging capability.

Graphene Quantum Dots Eradicate Resistant and Metastatic Cancer Cells by Enhanced Interfacial Inhibition.

Drug-resistant and metastatic cancer cells such as a small population of cancer stem cells (CSCs) play a crucial role in metastasis and relapse. Conventional small-molecule chemotherapeutics, however, are unable to eradicate drug-resistant CSCs owing to limited interface inhibitory effects. Herein, it is reported that enhanced interfacial inhibition leading to eradication of drug-resistant CSCs can be dramatically induced by self-insertion of bioactive graphene quantum dots (GQDs) into DNA major groove (MAG) sites in cancer cells.

Predictive Model of Restart-Up Pressure Drop after Shutdown for Heavy Oil-Water Ring Transportation Pipeline.

Aiming at the problem of restart-up for a heavy oil-water ring transportation pipeline due to instability and damage of the water ring, based on the self-developed design of a small indoor loop simulation experimental device and taking four kinds of ordinary heavy oil in the Lvda oilfield as the research object, the change trend of restart-up pressure drop with time is experimentally studied when the pipeline is restarted-up after shutdown at a constant water flow. On the basis of the regression analysis of the orthogonal restart-up experimental data of four factors (oil holdup, oil viscosity, standstill period, and water cleaning superficial velocity) and mixed levels by the statistical product and service solutions statistical analysis software, a multivariate nonlinear restart-up maximum pressure drop prediction model is established. Through analysis of the characteristics of each stage of the restart-up process, an exponential decay model of restart-up pressure drop with time is created.

Tumour microenvironment-responded Fe-doped carbon dots-sensitized cubic CuO for Z-scheme heterojunction-enhanced sono-chemodynamic synergistic tumor therapy.

The efficacy of electron-hole separation in a single sonosensitizer and the complexities of the tumor microenvironment (TME) present significant challenges to the effectiveness of sonodynamic therapy (SDT). Designing efficient sonosensitizers to enhance electron-hole separation and alleviate TME resistance is crucial yet challenging. Herein, we introduce a novel Z-scheme heterojunctions (HJs) sonosensitizer using Fe-doped carbon dots (CDs) as auxiliary semiconductors to sensitize cubic CuO (Fe-CDs@CuO) for the first time.

Single Atom Catalysts Remodel Tumor Microenvironment for Augmented Sonodynamic Immunotherapy.

The immunosuppressive tumor microenvironment (TME) is a huge hurdle in immunotherapy. Sono-immunotherapy is a new treatment modality that can reverse immunosuppressive TME, but the sonodynamic effects are compromised by overexpressed glutathione (GSH) and hypoxia in the TME. Herein, this work reports a new sono-immunotherapy strategy using Pd single atom catalysts to enhance positive sonodynamic responses to the immunosuppressive and sono-suppressive TME.

An NIR-II-photoresponsive CoSnO nanozyme for mild photothermally augmented nanocatalytic cancer therapy.

The main challenges of nanozyme-based tumor catalytic therapy (NCT) lie in the unsatisfactory catalytic activity accompanied by a complex tumor microenvironment (TME). A few nanozymes have been designed to possess both enzyme-like catalytic activities and photothermal properties; however, the previously reported nanozymes mainly utilize the inefficient and unsafe NIR-I laser, which has a low maximum permissible exposure limit and a limited penetration depth. Herein, we report for the first time an all-in-one strategy to realize mild NIR-II photothermally amplified NCT by synthesizing amorphous CoSnO nanocubes with efficient triple enzyme-like catalytic activities and photothermal conversion properties.

N-Heterocycle Modified Graphene Quantum Dots as Topoisomerase Targeted Nanoantibiotics for Combating Microbial Infections.

Developing next-generation antibiotics to eliminate multidrug-resistant (MDR) bacteria/fungi and stubborn biofilms is challenging, because of the excessive use of currently available antibiotics. Herein, the fabrication of anti-infection graphene quantum dots (GQDs) is reported, as a new class of topoisomerase (Topo) targeting nanoantibiotics, by modification of rich N-heterocycles (pyridinic N) at edge sites. The membrane-penetrating, nucleus-localizing, DNA-binding GQDs not only damage the cell walls/membranes of bacteria or fungi, but also inhibit DNA-binding proteins, such as Topo I, thereby affecting DNA replication, transcription, and recombination.

A Sonoresponsive and NIR-II-Photoresponsive Nanozyme for Heterojunction-Enhanced "Three-in-One" Multimodal Oncotherapy.

Although low-cost nanozymes with excellent stability have demonstrated the potential to be highly beneficial for nanocatalytic therapy (NCT), their unsatisfactory catalytic activity accompanied by intricate tumor microenvironment (TME) significantly hinders the therapeutic effect of NCT. Herein, for the first time, a heterojunction (HJ)-fabricated sonoresponsive and NIR-II-photoresponsive nanozyme is reported by assembling carbon dots (CDs) onto TiCN nanosheets. The narrow bandgap and mixed valences of Ti and Ti endow TiCN with the capability to generate reactive oxygen species (ROS) when exposed to ultrasound (US), as well as the dual enzyme-like activities of peroxidase and glutathione peroxidase.

Correlation between patient-specific quality assurance in volumetric modulated arc therapy and 2D dose image features.

In radiotherapy, air-filled ion chamber detectors are ubiquitously used in routine dose measurements for treatment planning. However, its use has been restricted by intrinsic low spatial resolution barriers. We developed one procedure for patient-specific quality assurance (QA) in arc radiotherapy by coalescing two adjacent measurement images into a single image to improve spatial resolution and sampling frequency, and investigated how different spatial resolutions affect the QA results.

How can green credit decrease social health costs? The mediating effect of the environment.

Green credit plays an important role in environmental protection and residents' health. This paper discusses the impact path of green credit on social health costs with the help of a quantile regression. The implementation of a green credit policy can decrease social health costs in China, and green credit works best in the economically developed Eastern region.

The impact of environment on college students' entrepreneurial intention based on the mediating effect of personality traits.

Introduction: The entrepreneurship rate of Chinese college students is relatively low. This study investigates the environment factors that influence college students' entrepreneurial intention as mediated by personality traits.

Methods: According to the entrepreneurial ecosystem theory, a hierarchical model of the environment factors was established which included three layers: personality traits as the micro system, family and education as the meso system, and social and policy support as the macro system.

Error detection using EPID-based 3D in vivo dose verification for lung stereotactic body radiotherapy.

Purpose: To investigate the error detectability limitations of an EPID-based 3D in vivo dosimetry verification system for lung stereotactic body radiation therapy (SBRT).

Methods: Thirty errors were intentionally introduced, consisting of dynamic and constant machine errors, to simulate the possible errors that may occur during delivery. The dynamic errors included errors in the output, gantry angle and MLC positions related to gantry inertial and gravitational effects, while the constant errors included errors in the collimator angle, jaw positions, central leaf positions, setup shift and thickness to simulate patient weight loss.

Application of Computer-Based Simulation Teaching Combined with PBL in Colorectal Tumor Hemorrhage.

Objective: This paper aims to explore the use of computer-based simulation teaching combined with PBL in colorectal tumor bleeding.

Methods: The outpatient department organized 21 nursing staffs to conduct computer simulation combined with PBL teaching, compared emergency theory and skill scores, and investigated the recognition of computer simulation teaching combined with PBL.

Results: The scores of theoretical knowledge examination before training were (84.

Graphitic-N-doped graphene quantum dots for photothermal eradication of multidrug-resistant bacteria in the second near-infrared window.

Developing efficient therapeutic strategies for combating bacterial infection remains a challenge owing to the indiscriminate utilization of antibiotics and the prevalence of multidrug-resistant (MDR) bacteria. Herein, highly graphitic-N-doped graphene quantum dots (N-GQDs) with efficient NIR-II photothermal conversion properties were synthesized for the first time for photothermal antibacterial therapy. The obtained N-GQDs exhibited strong NIR absorption ranging from 700 to 1200 nm, achieving high photothermal conversion efficiency of 77.

Electrospun flexible core-sheath PAN/PU/β-CD@Ag nanofiber membrane decorated with ZnO: enhance the practical ability of semiconductor photocatalyst.

It is necessary to effectively separate photocatalytic materials from water bodies and reuse catalysts for industrial wastewater treatment. Herein, a novel nanofiber membrane with enhanced light absorption and reusability of photocatalytic materials was prepared. The three-dimensional porous structure of the nanofibers helps the photocatalyst efficiently degrade pollutants.

Immobilization of laccase onto modified PU/RC nanofiber via atom transfer radical polymerization method and application in removal of bisphenol A.

In this study, 2-hydroxyethyl methacrylate (HEMA) was used as the monomers for surface grafting on electrospun PU/RC nanofiber membrane via atom transfer radical polymerization (ATRP) method, and the PU/RC-poly(HEMA) nanofiber membrane was investigated as a carrier for LAC. Free and immobilized LAC was characterized, and efficiency of bisphenol A (BPA) removal was determined. The results indicated that the PU/RC-poly(HEMA)-LAC showed relatively higher pH stability, temperature stability, and storage stability than free and PU/RC-LAC; moreover, more than 60% of the PU/RC-poly(HEMA)-LAC activity was retained after 10 cycles of ABTS treatment.

Physicochemical characteristics of oil-based cuttings from pretreatment in shale gas well sites.

Understanding the physicochemical characteristics of oil-based cuttings (OBCs) is an important foundation for subsequent treatment and management. The macro- and microscopic properties of white oil-based cuttings (WOBCs) and diesel-based cuttings (DBCs) after the different pretreatment steps have been assessed using scanning electron microscopy. The organic and inorganic compositions of OBCs have been analyzed using X-ray diffraction, Fourier-transform infrared spectrometry, and gas chromatography-mass spectrometry.

High-capacity aqueous zinc batteries using sustainable quinone electrodes.

Quinones, which are ubiquitous in nature, can act as sustainable and green electrode materials but face dissolution in organic electrolytes, resulting in fast fading of capacity and short cycle life. We report that quinone electrodes, especially calix[4]quinone (C4Q) in rechargeable metal zinc batteries coupled with a cation-selective membrane using an aqueous electrolyte, exhibit a high capacity of 335 mA h g with an energy efficiency of 93% at 20 mA g and a long life of 1000 cycles with a capacity retention of 87% at 500 mA g. The pouch zinc batteries with a respective depth of discharge of 89% (C4Q) and 49% (zinc anode) can deliver an energy density of 220 Wh kg by mass of both a C4Q cathode and a theoretical Zn anode.

Identifying odd/even-order binary kernel slices for a nonlinear system using inverse repeat m-sequences.

The study of various living complex systems by system identification method is important, and the identification of the problem is even more challenging when dealing with a dynamic nonlinear system of discrete time. A well-established model based on kernel functions for input of the maximum length sequence (m-sequence) can be used to estimate nonlinear binary kernel slices using cross-correlation method. In this study, we examine the relevant mathematical properties of kernel slices, particularly their shift-and-product property and overlap distortion problem caused by the irregular shifting of the estimated kernel slices in the cross-correlation function between the input m-sequence and the system output.

Local heating realization by reverse thermal cloak.

Transformation thermodynamics, as one of the important branches among the extensions of transformation optics, has attracted plentiful attentions and interests recently. The result of transformation thermodynamics, or called as "thermal cloak", can realize isothermal region and hide objects from heat. In this paper, we presented the concept of "reverse thermal cloak" to correspond to the thermal cloak and made a simple engineering definition to identify them.