Publications by authors named "Jinxiu Liang"
Article Synopsis
- Hereditary spastic paraplegia (HSP) is a rare disorder primarily caused by mutations in the SPAST gene, with a complex pathogenic mechanism that isn't fully understood.
- Researchers investigated a Chinese family to identify the causative gene of autosomal dominant HSP-SPAST and discovered a novel splice site variant that affects gene expression.
- Experiments showed that this mutation leads to a truncated protein causing cellular accumulation and resulting in significant developmental issues in zebrafish, including defects in motor neuron pathfinding and axon loss.
Background: Exosomes released by cardiomyocytes are essential mediators of intercellular communications within the heart, and various exosomal proteins and miRNAs are associated with cardiovascular diseases. However, whether the endosomal sorting complex required for transport (ESCRT) and its key component Alix is required for exosome biogenesis within cardiomyocyte remains poorly understood.
Methods: Super-resolution imaging was performed to investigate the subcellular location of Alix and multivesicular body (MVB) in primary cardiomyocytes.
Background: Idiopathic membranous nephropathy (IMN) is the leading cause of nephrotic syndrome in the elderly. The treatment of idiopathic membranous nephropathy is quite challenging due to the particularity of elderly patients. This study intends to investigate the clinicopathological characteristics and initial therapeutic effect of idiopathic membranous nephropathy among elderly patients.
View Article and Find Full Text PDFBackground: This study aimed to further evaluate the accuracy of eleven GFR equations in different subgroups of an elderly Chinese hospitalized population.
Methods: All participants of the study were divided into seven separate groups including age-subgroup, sex-subgroup, GFR Staging-subgroup and whether combined with diabetic, hypertensive, coronary heart disease (CHD) and cerebrovascular disease. Referring to Tc-99m-DTPA dual plasma sample clearance method, six serum creatinine (Cr)-based [Cockcroft-Gault (CG), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Lund-Malmö Revised (LMR), Berlin Initiative Study (BIS1), Full Age Spectrum (FAS) and European Kidney Function Consortium (EKFC)], two serum cystatin C(Cys)-based (CKD-EPI and FAS), and three Cr-Cys combination based (CKD-EPI, BIS2 and FAS) equations were employed.
Background: The accuracy of the estimated glomerular filter rate (eGFR) in elderly patients is debatable. In 2020, a new creatinine-based equation by European Kidney Function Consortium (EKFC) was applied to all age groups. The objective of this study was to assess the appropriateness of the new EKFC equation with Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Lund-Malmö Revised (LMR), Berlin Initiative Study 1 (BIS1), and full age spectrum (FAS) equations based on serum creatinine (SCR) for elderly Chinese patients.
View Article and Find Full Text PDFHeart disease is the leading cause of mortality worldwide. Due to the limited proliferation rate of mature cardiomyocytes, adult mammalian hearts are unable to regenerate damaged cardiac muscle following injury. Instead, injured area is replaced by fibrotic scar tissue, which may lead to irreversible cardiac remodeling and organ failure.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the effectiveness of different Bowie-Dick test kits in evaluating the performance of pressure steam sterilizers under varying levels of simulated gas leakage.
- Four brands of test kits were tested at four different leakage rates, resulting in 48 experimental setups.
- The analysis found significant differences in test judgments based on both personnel and brand, with brand 4 performing the best and brand 2 the worst in evaluating air leakage.
Existing enhancement methods are empirically expected to help the high-level end computer vision task: however, that is observed to not always be the case in practice. We focus on object or face detection in poor visibility enhancements caused by bad weathers (haze, rain) and low light conditions. To provide a more thorough examination and fair comparison, we introduce three benchmark sets collected in real-world hazy, rainy, and low-light conditions, respectively, with annotated objects/faces.
View Article and Find Full Text PDFEthnopharmacological Relevance: Monascus-fermented rice product (MFRP) has been regarded as a dietary supplement and traditional medicine with circulation-promoting effects in China and other countries for centuries.
Aim Of The Study: This study was carried out to profile the chemical components in MFRP, and provide available information for elucidating the potential lipid-lowering compounds other than monacolins.
Materials And Methods: High-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-QTOF MS) and gas chromatography coupled with mass spectrometry (GC-MS) methods were applied to comprehensive analysis of chemical components in MFRP.
Herbal medicines (HMs) are an important source of drugs. In this study, an efficient strategy integrating ultrafiltration LC-MS, microplate bioassays, and molecular docking was proposed to screen high-potency enzyme inhibitors from HMs. Using this strategy, the structure-activity relationships (SARs) including binding-affinity-based SAR, enzymatic-activity-based SAR, and structural-complementarity-based SAR of compounds in an HM can be analyzed to provide abundant information for drug discovery.
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