Publications by authors named "Jinxing Huang"
Article Synopsis
- The study investigates the safety and effectiveness of holmium laser prostatectomy (HoLEP) compared to transurethral prostatectomy (TURP) for treating benign prostatic hyperplasia (BPH), particularly in elderly patients.
- It analyzed data from 565 HoLEP and 76 TURP patients, focusing on various characteristics across different age groups and comparing outcomes in patients over 80.
- The results show that HoLEP offers several advantages, such as shorter recovery times and better postoperative outcomes, making it a superior option for elderly patients with BPH.
A redox-responsive nanosystem to suppress chemoresistant lung cancer through targeting STAT3.
J Control Release
November 2023
Article Synopsis
- Cancer stem cells (CSCs) play a key role in tumor growth and treatment failure, and BBI608 effectively targets and kills these cells by inhibiting the STAT3 pathway.
- BBI608 is enhanced for delivery using redox-responsive nanoparticles that release the drug in high glutathione environments, ensuring better bioavailability and tumor accumulation.
- This new formulation demonstrates superior anti-tumor effects against chemoresistant non-small cell lung cancer (NSCLC) in various models, indicating its potential as an effective treatment strategy.
Article Synopsis
- Small interfering RNA (siRNA) shows potential in treating diseases, especially cancers, but faces significant challenges in clinical applications.
- Recent advancements in siRNA chemistry and delivery methods have led to approved treatments for some non-cancerous liver diseases, yet overcoming barriers in cancer therapeutics remains difficult.
- Current strategies involve improving siRNA delivery through non-viral nanoparticles, selecting effective target genes, and combining therapies, while addressing ongoing challenges is essential for future success in clinical settings.
A hydroxamic acid based microtubule-destabilizing agent (MDA) SKLB-14b was discovered in this study, which was derived from shortening the linker length of the HDAC6 and microtubule dual-target inhibitor SKLB-23bb. SKLB-14b exhibited low nanomolar IC values on a wide spectrum of human cancer cell lines including both sensitive and multidrug-resistant cell lines. Surprisingly, its anti-proliferative activity relied on the presence of the hydroxamic acid group but lost inhibitory activity against HDACs.
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- YAP is a key factor in causing resistance to EGFR-TKIs in non-small-cell lung cancer, making it a target for new treatments.
- A new therapeutic approach uses nanoparticles to deliver gefitinib (an EGFR-TKI) and YAP-siRNA together, allowing for effective treatment of resistant cancer cells.
- This combination therapy works by blocking cancer growth pathways and inducing tumor cell death, showing promise for overcoming drug resistance in NSCLC while minimizing side effects.
Article Synopsis
- The study created a repository of patient-derived xenograft (PDX) models for non-small cell lung cancer (NSCLC) to investigate their ability to maintain tumor heterogeneity.
- The research involved implanting NSCLC specimens into mice, examining protein expression and conducting genetic analyses to confirm that PDX models mirrored the original patient tumors.
- The results demonstrated that PDX models effectively replicate the complex characteristics of NSCLC, proving useful for testing responses to various cancer treatments.
Plane wave imaging (PWI) is attracting more attention in industrial nondestructive testing and evaluation (NDT&E). To further improve imaging quality and reduce reconstruction time in ultrasonic imaging with a limited active aperture, an optimized PWI algorithm was proposed for rapid ultrasonic inspection, with the comparison of the total focusing method (TFM). The effective area of plane waves and the space weighting factor were defined in order to balance the amplitude of the imaging area.
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- Gold nanoparticles (AuNPs) show potential in biomedical applications, but their interactions with biological systems need more exploration.
- The study investigated how the size of AuNPs affects their uptake and toxicity in both cancer cells (HepG2) and normal cells (L02), finding that smaller particles had higher cytotoxicity.
- Results indicated that 5 nm AuNPs induced apoptosis in cancer cells while causing necrosis in normal cells, with larger particles exhibiting longer circulation times and specific organ distribution, highlighting the importance of particle size and cell type in medical applications.
Emerging evidence indicates that long noncoding RNAs (lncRNAs) play important roles in the regulation of cell differentiation by acting as competing endogenous RNA (ceRNA). However, the regulatory mechanisms of lncRNA and the lncRNA-associated ceRNA network involved in adipogenic differentiation of chicken preadipocytes remain elusive. Here, we first constructed the chicken preadipocyte in vitro induction model.
View Article and Find Full Text PDFA previous study reported the decreased expression of long non-coding RNA mortal obligate RNA transcript (lncRNA MORT) in 16 types of cancer, while the functionality of lncRNA MORT in cancer biology remains unknown. Therefore, the present study was conducted to characterize the functionality of lncRNA MORT in prostate carcinoma, a common cancer type worldwide. lncRNA MORT expression level was downregulated in tumor tissues compared with that in the adjacent healthy tissues of patients with prostate carcinoma.
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- Iron oxide nanoparticles (IONPs) have great potential for biomedical uses, but there's limited knowledge on how they interact with biological systems, particularly how they are taken up and distributed in cells and tissues.
- This study utilized various imaging techniques to explore how IONPs are internalized and distributed in macrophages, cancer cells, and in tumor models, finding that the uptake is influenced by both dosage and cell type, primarily occurring through energy-dependent caveolae-mediated endocytosis.
- Results showed that after intravenous injection in cancer-mouse models, IONPs mostly accumulated in the liver and spleen, while also showing significant uptake in tumors, with some presence in the kidneys and brain, highlighting the importance of multi-modal imaging for
Background: MicroRNAs (miRNAs) are single-stranded, endogenous, non-coding RNAs that are increased or decreased in almost all cancer types, and they paly crucial roles in the tumorigenesis as well as development.
Materials And Methods: 90 patients diagnosed with bladder cancer were enrolled in the present study. The bladder cancer tissues or adjacent normal tissues were obtained from the tumor area or adjacent normal zone.
Article Synopsis
- Iron oxide nanoparticles (IONPs) are being studied for biomedical use, but their interactions with biological systems are not fully understood.
- Research found that polyethylenimine (PEI)-coated IONPs had higher cellular uptake and caused more cytotoxic effects compared to PEGylated IONPs, which induced less toxicity but were better at triggering protective autophagy.
- IONPs showed a tendency to accumulate in organs like the liver and spleen, with 10 nm PEGylated IONPs demonstrating the highest tumor uptake and lower toxicity, highlighting the importance of size and coating in their application.
This study aimed to investigate the pivotal role of cystatin B (CSTB) in the development of gastric cancer and to explore its possible regulatory mechanism. Human gastric cancer SGC-7901 cells as a model in vitro were transfected with plasmid PCDNA3.1-CSTB and siRNA-CSTB using Lipofectamine 2000.
View Article and Find Full Text PDFObjective: To evaluate the efficacy and safety of super-mini percutaneous nephrolithotomy (SMP) in the treatment of pediatric kidney stones.
Patients And Methods: We reviewed the records of 111 children with renal stones treated with SMP technique in four different centers between September 2014 and September 2015. The indications for SMP treatment in all these kids were either previously failed shock wave lithotripsy or retrograde intrarenal surgery approaches, according to their parents' preferences.
A Prediction Model for the Peripheral Arterial Disease Using NHANES Data.
Medicine (Baltimore)
April 2016
Article Synopsis
- The study aims to create and validate models to predict the risk of peripheral arterial disease (PAD) using data from the National Health and Nutrition Examination Surveys (NHANES) from 1999-2002.
- The final predictive model includes important variables like age, race, sex, pulse pressure, the TC to HDL ratio, and smoking status, and shows significant odds ratios for these factors affecting PAD risk.
- Internal and external validations indicated that the model has moderate usefulness in predicting PAD risk among the general population in the U.S., with AUC values suggesting good calibration.