Ferroptosis-related gene signature predicts prognosis and immune microenvironment in prostate cancer.

Background: Ferroptosis, an iron-dependent form of programmed cell death, significantly impacts cancer, yet its link to prostate cancer (PCa) prognosis remains underexplored. This study aims to develop and validate a ferroptosis-related gene signature to predict PCa prognosis and immune microenvironment differences, potentially identifying therapeutic targets.

Methods: RNA-sequencing data of 478 PCa patients and corresponding clinical data were downloaded from The Cancer Genome Atlas (TCGA) database.

Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXXVI. Tsugaforrestiacids A-O: Structurally diverse C-18 carboxylated diterpenoids from the twigs and needles of the 'vulnerable' conifer Tsuga forrestii and their inhibitory effects on ATP-citrate lyase.

An extensive phytochemical investigation on the EtOAc-soluble fraction of the 90% MeOH extract from the twigs and needles of the 'vulnerable' Chinese endemic conifer Tsuga forrestii (Forrest's hemlock) led to the isolation and characterization of 50 structurally diverse diterpenoids, including 15 unreported C-18 carboxylated ones (tsugaforrestiacids A-O, 1-15, resp.). Among them, compounds 1-7 are abieten-18-oic acids, compound 8 is an abieten-18-succinate, and compounds 10-12 are podocarpen-18-oic acids, whereas compounds 13-15 are pimarane-type, isopimarane-type, and totarane-type diterpenoid acids, respectively.

Early detection and stratification of colorectal cancer using plasma cell-free DNA fragmentomic profiling.

Timely accurate and cost-efficient detection of colorectal cancer (CRC) is of great clinical importance. This study aims to establish prediction models for detecting CRC using plasma cell-free DNA (cfDNA) fragmentomic features. Whole-genome sequencing (WGS) was performed on cfDNA from 620 participants, including healthy individuals, patients with benign colorectal diseases and CRC patients.

Effect of ultrasonic pretreatment on fermentation performance and quality of fermented hawthorn pulp by lactic acid bacteria.

In order to explore the effects of ultrasonic pretreatment on the fermentation performance and quality characteristics of fermented hawthorn pulp. Five types of fermented hawthorn pulp were obtained using 0 W for 5 min, 300 W for 5 min, 360 W for 5 min, 420 W for 5 min, 540 W for 5 min. The fermentation performance and quality of fermented hawthorn pulp were characterized.

Relationship between oxidative balance score and kidney stone prevalence in US adults.

Background: The aim of the study was to assess the relationship between prevalence of kidney stones (KS) and the oxidative balance score (OBS).

Methods And Materials: Participants who participated in the KS questionnaire was extracted from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. A series of covariates were also obtained.

Enantioselective Synthesis of 2,3,3a,8a-Tetrahydrofuro[2,3-]benzofuran Scaffolds Enabled by Cu(II)/SPDO-Catalyzed [3+2] Cycloaddition of 2,3-Dihydrofuran and Quinone Esters.

An asymmetric [3+2] cycloaddition of quinone esters with 2,3-dihydrofuran has been realized via a newly developed Cu(II)/SPDO complex. It provides straightforward access to 2,3,3a,8a-tetrahydrofuro[2,3-]benzofurans (TFB) with high enantioselectivity (up to 97.5:2.

Clinicopathological features of papillary thyroid carcinoma in HIV-infected patients.

Background: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy, with an increasing incidence over the last decades. Human immunodeficiency virus (HIV)-induced immune deficiency was one of risk factors for cancer tumorigenesis and development. The aim of this study was to describe the clinicopathological features of PTC in HIV-infected patients and discuss possible connections between PTC and HIV infection.

Clinical Efficacy and Safety Evaluation of Calcitriol Combined with Bisphosphonates in the Therapy of Postmenopausal Osteoporosis: Based on a Retrospective Cohort Study.

A retrospective cohort study to explore the clinical efficacy and safety evaluation of calcitriol combined with bisphosphonates in the therapy of postmenopausal osteoporosis is conducted. The postmenopausal osteoporosis sufferers admitted to our hospital from January 2020 to June 2021 are retrospectively collected and divided into a contrast set and a study set, with 60 cases in each set. For the contrast set, all sufferers are treated with bisphosphonates.

Detection and monitoring of HBV-related hepatocellular carcinoma from plasma cfDNA fragmentation profiles.

Most hepatocellular carcinomas (HCCs) are associated with hepatitis B virus infection (HBV) in China. Early detection of HCC can significantly improve prognosis but is not yet fully clinically feasible. This study aims to develop methods for detecting HCC and studying the carcinogenesis of HBV using plasma cell-free DNA (cfDNA) whole-genome sequencing (WGS) data.

Effect of water chemistry on nitrogen transformation, dissolved organic matter composition and microbial community structure in hyporheic zone sediment columns.

Controlled surface water systems, including those with dams lead to dynamic stage changes that alter the fluctuation directions of flow exchange in the hyporheic zones (HZ). However, the nitrogen transformation, dissolved organic matter (DOM) composition, and microbial community responding to variable scenarios of water source and hyporheic exchange are poorly studied. The present work investigated nitrogen transformation in HZ sediments, focusing on how microbial community structure and biological functions related to nitrogen transformation and sediment-attached DOM compositions.

Clinical diagnosis and treatment of primary thyroid tuberculosis: a retrospective study.

Background: Primary thyroid tuberculosis (PTT) is an uncommon type of extrapulmonary tuberculosis, which is caused by Mycobacterium tuberculosis. It does not have specific clinical manifestations, and most cases are diagnosed through postoperative histopathological examination.

Objective: To evaluate the diagnostic pattern and management strategy among patients with primary thyroid tuberculosis.

Value of Defecography in the Diagnostic and Therapeutic Management of the Modified Wells Procedure for Rectal Prolapse.

The main aim of this study was to explore the role of defecography in the preoperative diagnosis and postoperative evaluation of rectal prolapse surgery (modified Wells procedure). We collected and summarized the X-ray performance and then analyzed the results of 107 patients with defecatory dysfunction who underwent defecography from January 2020 to March 2021. Furthermore, the preoperative and 6-month postoperative defecography results and clinical symptoms of 25 patients who underwent rectal prolapse surgery (modified Wells procedure) were compared.

The psychometric properties of the Chinese version of the attitude survey inclusive education-parents.

Objective: The purpose of this study was to examine the psychometric properties of the Attitude Survey Inclusive Education-Parents (ASIE-P) in mainland China.

Methods: A sample of 1,656 parents (70.59% female) from 27 provinces in mainland China completed the online survey.

Multiple endocrine neoplasia type 1 combined with thyroid neoplasm: A case report and review of literatures.

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary tumor syndrome inherited in an autosomal dominant manner and presents mostly as parathyroid, endocrine pancreas (such as gastrinoma) and anterior pituitary tumors. At present, papillary thyroid carcinoma (PTC) and nodular goiter are not regarded as components of MEN1.

Case Summary: A 35-year-old woman presented with MEN1 accompanied by coinstantaneous PTC and nodular goiter.

Identification of Policies Based on Assessment-Optimization Model to Confront Vulnerable Resources System with Large Population Scale in a Big City.

The conflict between excessive population development and vulnerable resource (including water, food, and energy resources) capacity influenced by multiple uncertainties can increase the difficulty of decision making in a big city with large population scale. In this study, an adaptive population and water-food-energy (WFE) management framework (APRF) incorporating vulnerability assessment, uncertainty analysis, and systemic optimization methods is developed for optimizing the relationship between population development and WFE management (P-WFE) under combined policies. In the APRF, the vulnerability of WFE was calculated by an entropy-based driver-pressure-state-response (E-DPSR) model to reflect the exposure, sensitivity, and adaptability caused by population growth, economic development, and resource governance.

Clinical Efficacy of Tacrolimus Ointment + 3% Boric Acid Lotion Joint Chinese Angelica Decoction in Chronic Perianal Eczema.

Objective: To unearth the clinical efficacy of tacrolimus ointment + 3% boric acid lotion joint Chinese angelica decoction in chronic perianal eczema.

Methods: Patients with chronic perianal eczema admitted to hospital from June 2018 and June 2019 were retrospectively analyzed. Patients in the control group ( = 38) underwent basic therapy with tacrolimus ointment + 3% boric acid lotion, whereas those in the observation group ( = 38) were given oral Chinese angelica decoction on the basis of the above therapy.

Copper-Nitrene-Catalyzed Desymmetric Oxaziridination/1,2-Alkyl Rearrangement of 1,3-Diketones toward Bicyclic Lactams.

Although copper-nitrene has been extensively studied as a versatile active species in various transformations, asymmetric reactions involving copper-nitrene have been limited to the aziridination of olefins. Herein, we report the novel copper-nitrene-catalyzed desymmetric oxaziridination reaction of cyclic diketones with alkyl azides and the subsequent rearrangement of the resulting highly active intermediate, which produces a synthetically challenging chiral bicyclic lactam containing a quaternary carbon center. This procedure not only enriches the copper-nitrene-catalyzed asymmetric reactions, but also provides an alternative strategy to address the inherent challenges of catalytic asymmetric Schmidt reactions.

Inhibition of microRNA-130b Alleviated Podocyte Injury Induced by Puromycin Aminonucleoside .

Objective: To investigate the effect of microRNA-130b (miR-130b) on podocyte injury induced by puromycin aminonucleoside (PAN) and its possible mechanisms.

Methods: The immortalized podocytes (HPC) were treated by 25, 50, or 100 μg/mL PAN, then real-time polymerase chain reaction (PCR) was used to detect the expression of miR-130b. The HPC were transfected with miR-130b inhibitor or normal control (NC) inhibitor, and then the cells were stimulated with 100 μg/mL PAN for 24h.

Expression and clinical significance of B cell translocation gene 2 in esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) is widely known as a highly fatal cancer, and thus it is important to identify tumor-specific and radiosensitivity-specific markers in ESCC. B cell translocation gene 2 (BTG2) has been considered a novel tumor suppressor gene or radiotherapy sensitivity-associated gene. However, the relationship between BTG2 and ESCC development and radiotherapy sensitivity is uncertain.

[Occurrence of Antibiotics and Antibiotic Resistance Genes in Representative Drinking Water Resources in Jiangsu Province].

Emerging contaminants including antibiotics and antibiotic resistance genes (ARGs) have been frequently detected in drinking water resources. In this study, the occurrence of antibiotics and ARGs in various environmental matrices in representative drinking water sources in Jiangsu Province and their influencing factors were explored. Five representative drinking water sources in northern, central, and southern Jiangsu were selected.

Bacterial and fungal assemblages and functions associated with biofilms differ between diverse types of plastic debris in a freshwater system.

Once in aquatic ecosystems, plastics can be easily colonized by diverse microbes, and these microbial communities on plastics-the 'plastisphere'-often differ from the communities in the surrounding water and other substrates. However, our knowledge of plastic-associated bacterial and fungal communities on diverse plastics in freshwater is poor, especially for fungal communities. Furthermore, intraspecies interactions among bacterial and fungal communities colonized on diverse plastics are poorly known.

Taking Justice Into Their Own Hands: Predictors of Netilantism Among Cyber Citizens in Hong Kong.

This research examined the characteristics and predicting indicators of netizens which contribute to "Human Flesh Searching" and internet vigilantism. Human Flesh Searching (HFS) is a form of collective online behavior where netizens contribute information to social media and/or networking platforms about a certain event or a target individual or group to achieve what they regard as justice. It has been used to identify and investigate crime.

Grain size tunes microbial community assembly and nitrogen transformation activity under frequent hyporheic exchange: A column experiment.

Hyporheic zones (HZ) are hotspots for biogeochemical reactions where groundwater and surface water mix. River dam buildings and other hydrologic controls alter the sediment grain size distribution and modify the downstream hyporheic exchange, with cascading effects on geochemical and microbial processes in river corridors. In this lab-scale column experiment, the N transformations in HZ filled with sediments in different grain sizes were investigated with a focus on understanding the interplay among variational hydraulic connectivity, microbial community structure, functional potential under frequent groundwater-surface water exchange.

Total synthesis of quinolactacin-H from marine-derived sp. ENP701 and biological activities.

The quinolactacins are a family of pyrroloquinoline-type natural products from sp. From the organic extract of sp. ENP701 fermentation broth, a microorganism from the east China sea, one new quinolactacin was isolated and named quinolactacin-H.