Disulfiram-Loaded PLGA nanoparticles modified with a Phenyl borate chitosan Conjugate enhance hepatic carcinoma treatment.

Disulfiram (DSF), which has been traditionally used to treat alcoholism, has been shown to inhibit tumor growth, indicating its potential as an anticancer agent. However, its development and application are hindered by its poor water solubility, instability in physiological environments, and low bioavailability. In this study, phenylboronic acid-chitosan (PBA-CS) grafts were synthesized using the carbodiimide method.

A tracing method of airborne bacteria transmission across built environments.

Disease transmission across built environments has been found to be a serious health risk. Airborne transmission is a vital route of disease infection caused by bacteria and virus. However, tracing methods of airborne bacteria in both lab and field research failed to veritably express the transporting process of microorganism in the air.

A novel cfr-carrying Tn7 transposon derivative characterized in Morganella morganii of swine origin in China.

Objectives: To characterize the presence and genetic environment of the multiresistance gene cfr in bacterial isolates from a swine farm.

Methods: A total of 97 bacterial isolates, recovered from 32 faecal swabs obtained on one farm, were tested for the presence of the cfr gene by PCR. Species identification of the one cfr-positive strain was conducted using the BD PhoenixTM 100 Automated Microbiology System.

Spatial variability and evaluation of airborne bacteria concentration in manure belt poultry houses2.

Manure belt poultry houses were widely used for egg production. However, reliable spatial distribution of airborne bacteria data from long-term on-farm monitoring in manure belt houses are scarce. In this study, the airborne bacteria were collected by the Andersen air microorganism sampler in a 4 tiers and an 8 tiers layer house, respectively.

Sensitive and rapid detection of Salmonella enterica serovar Indiana by cross-priming amplification.

Salmonella enterica serovar Indiana (S. Indiana) was the most frequently reported foodborne pathogen, which has a broad host range including poultry, swine, and humans. Traditional methods used for the detection of S.

Distribution of Salmonella Enteritidis in internal organs and variation of cecum microbiota in chicken after oral challenge.

The aim study was to explore the distribution of Salmonella Enteritidis (S. enteritidis) in internal organs and variation of cecum microbiota in newly hatched chicken after oral challenge during a 21-day period. The quantities of S.

PGI2 Is a Novel SGI1-Relative Multidrug-Resistant Genomic Island Characterized in Proteus mirabilis.

A novel 61,578-bp genomic island named genomic island 2 (PGI2) was characterized in of swine origin in China. The 23.85-kb backbone of PGI2 is related to those of genomic island 1 and genomic island 1.

Frequency of antimicrobial resistance and integron gene cassettes in Escherichia coli isolated from giant pandas (Ailuropoda melanoleuca) in China.

Escherichia coli (E. coli) is considered as a common opportunistic pathogen, which causes seriously intestinal infections to giant pandas (Ailuropoda melanoleuca) and other animals. The aim of this investigation was to characterize the antimicrobial resistance and integron gene cassettes in E.

Tn, a Novel Multidrug Resistance Transposon Characterized in a Proteus mirabilis Isolate from Chicken in China.

A novel 65.8-kb multidrug resistance transposon, designated Tn, was characterized in a isolate from chicken in China. Tn contains 18 different antimicrobial resistance genes, including cephalosporinase gene and fluoroquinolone resistance genes and ' It carries a class 1/2 hybrid integron composed of and a 3' conserved segment of the class 1 integron.

Prevalence of antimicrobial resistance and integron gene cassettes in Escherichia coli isolated from yaks (Poephagus grunniens) in Aba Tibetan Autonomous Prefecture, China.

Background: Escherichia coli (E. coli) is one of the most relevant opportunistic pathogenic bacteria as it may cause severe morbidity and mortality in yaks (poephagus grunniens). In recent years, several kinds of antibiotics have been widely used in Tibetan areas to treat the bacterial diseases, resulting in serious repercussions on the bacterial antibiotic resistance in yaks.