Publications by authors named "Jinxin Lan"

Background: Glioblastoma multiforme (GBM) exhibits a cellular hierarchy with a subpopulation of stem-like cells known as glioblastoma stem cells (GSCs) that drive tumor growth and contribute to treatment resistance. NAD(H) emerges as a crucial factor influencing GSC maintenance through its involvement in diverse biological processes, including mitochondrial fitness and DNA damage repair. However, how GSCs leverage metabolic adaptation to obtain survival advantage remains elusive.

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Applying cellulose paper on the triboelectric material is the trend of developing eco-friendly triboelectric nanogenerator (TENG). However, the researchers always pay attention to improve the triboelectric property of cellulose paper by the grafting of functional groups and the introduction of conductive or high dielectric property materials, while neglecting the effects of lignocellulose fiber composition including hemicellulose and lignin. In this work, the contents of hemicellulose and lignin were adjusted by sodium hydroxide and sodium chlorite, respectively; and the effects of hemicellulose and lignin on the triboelectric performance of cellulose paper were evaluated.

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Article Synopsis
  • This study presents a unique reaction that allows the synthesis of fluorine-containing oxindoles and amides using -alkylsulfonylated acrylamides in conjunction with an electron donor-acceptor complex.
  • The key innovation lies in controlling the reaction through different electron donors, enabling diverse product formation.
  • Benefits of this method include a wide range of compatible substrates, no need for metal or photocatalysts, and robust tolerance for various functional groups.
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  • Parkinson disease (PD) is a major health issue in China, being the third leading cause of death among older adults, with a focus on analyzing mortality trends from 2013 to 2021.
  • The study found that the age-standardized mortality rate (ASMR) of PD nearly doubled during this timeframe, significantly affecting males and increasing with age, while also varying by geographic areas.
  • Predictions indicate that PD mortality rates could rise to 2.66 per 100,000 individuals by 2040, highlighting the need for intensified prevention efforts particularly in urban settings and among older populations.
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Background: Radiation-induced brain injury (RIBI) is a debilitating sequela after cranial radiotherapy. Research on the topic of RIBI has gradually entered the public eye, with more innovations and applications of evidence-based research and biological mechanism research in the field of that. This was the first bibliometric analysis on RIBI, assessing brain injury related to radiation articles that were published during 1998-2023, to provide an emerging theoretical basis for the future development of RIBI.

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As the most abundant renewable resource, cellulose fibers are potential candidates for use in health-protective clothing. Herein, we demonstrate a novel strategy for preparing cellulose fiber with prominent antibacterial and antiviral performance by the synergistic effect of amino groups and sulfonic acid groups. Specifically, guanylated chitosan oligosaccharide (GCOS) and N-sulfopropyl chitosan oligosaccharide (SCOS) were synthesized and chemically grafted onto cellulose fibers (CFs) to endow the fibers with antibacterial and antiviral properties.

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  • * Although the overall incidence of SAH increased by 37.09% since 1990, age-standardized rates showed a decline, especially in high-income regions; mortality rates and disability-adjusted life years (DALYs) also decreased over time.
  • * The main demographic affected was those aged 50-69, with metabolic risk factors like high blood pressure being the leading contributors to SAH burden, while females generally experienced lower rates than males.
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  • - Glioblastoma multiforme (GBM) is a highly aggressive brain cancer, and while tumor electric field therapy (TEFT) shows potential as a treatment, its mechanisms are not fully understood, particularly concerning its interaction with the extracellular matrix (ECM).
  • - A study using T98G GBM cells found that TEFT significantly altered gene expression linked to the ECM, notably upregulating the hub gene COL6A1, which is associated with poorer prognosis in GBM and is particularly abundant in malignant cell types.
  • - The results indicate that TEFT may inhibit GBM progression by downregulating COL6A1, disrupting its interaction with another protein (ITGA5), and thereby suppressing the focal
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Bacteria and virus infections have posed a great threat to public health and personnel safety. For realizing rapid sterilization of the bacteria and virus, electrical stimulation sterilization was adopted to endow cellulose fibers with instantaneous antibacterial and antiviral properties. In the proposed strategy, the fiber is fluffed by mechanical refining, and then by means of the hydrogen bond between hydroxyl and aniline, the polyaniline (PANI) directionally grows vertically along the fine fibers via in-situ oxidative polymerization.

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Background: Glioblastoma multiforme (GBM) is an aggressive malignant tumor with a high mortality rate and is the most prevalent primary intracranial tumor that remains incurable. The current standard treatment, which involves surgery along with concurrent radiotherapy and chemotherapy, only yields a survival time of 14-16 months. However, the introduction of tumor electric fields therapy (TEFT) has provided a glimmer of hope for patients with newly diagnosed and recurrent GBM, as it has been shown to extend the median survival time to 20 months.

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Background: Vocal cord polyps are commonly encountered in the otorhinolaryngology department. The risk of anesthesia is high in patients with large vocal cord polyps. Awake intubation with appropriate airway tools provides a favorable safety profile.

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Background: Hemoglobin-to-red cell distribution width ratio (HRR) has shown good prognostic value in various cancers. However, the relationship between HRR and outcomes in critically ill patients with traumatic brain injury (TBI) remains unclear. This study aimed to investigate the association between HRR and mortality among critically ill patients with TBI.

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The worldwide spread of COVID-19 has put a higher requirement for personal medical protective clothing, developing protective clothing with sustained antibacterial and antiviral performance is the priority for safe and sustaining application. For this purpose, we develop a novel cellulose based material with sustained antibacterial and antiviral properties. In the proposed method, the chitosan oligosaccharide (COS) was subjected to a guanylation reaction with dicyandiamide in the presence of Scandium (III) triflate; because of the relatively lower molecular weight and water solubility of the COS, GCOS (guanylated chitosan oligosaccharide) with high substitution degree (DS) could be successfully synthetized without acid application.

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The worldwide outbreak of SARS-CoV-2 has attracted extensive attention to antibacterial and antivirus materials. Cellulose is the most potential candidate for the preparation of green, environmentally friendly antibacterial and antiviral materials. Herein, modified cellulosic fibers with sustained antibacterial and antiviral performance was prepared by introducing chitosan oligosaccharide onto the fibers.

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PTPN2 (protein tyrosine phosphatase non-receptor 2), also called TCPTP (T cell protein tyrosine phosphatase), is a member of the PTP family signaling proteins. Phosphotyrosine-based signaling of this non-transmembrane protein is essential for regulating cell growth, development, differentiation, survival, and migration. In particular, PTPN2 received researchers' attention when Manguso et al.

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Breast cancer has become the most newly-diagnosed cancer and the 5 leading cause of cancer death worldwide. The 5-year survival rate of breast cancer is about 90%. However, the 5-year survival rate drops to <30% when metastasis to distant sites occurs.

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A large amount of research has proven that monocyte chemotactic protein-1 (MCP-1) is associated with different types of disease, including autoimmune, metabolic and cardiovascular diseases. In addition, several studies have found that MCP-1 is associated with tumor development. MCP-1 expression level in the tumor microenvironment is associated with tumor development, including in tumor invasion and metastasis, angiogenesis, and immune cell infiltration.

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The development of conductive, soft, ultra-stretchable, and asymmetrically adhesive hydrogels is difficult and essential for both wearable electronics and anti-adhesion tissue dressings. In particular, there is still no simple, effective and universal approach to construct an asymmetrically adhesive multifunctional hydrogel. Here, we first synthesized lignosulfonate sodium (LS)-doped PAA hydrogels with uniform adhesion (adhesive strength: ~30.

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