Assessment of Risk Factors for Coronary Artery Disease and Severity by Coronary Computed Tomography Angiography Imaging.

Objective: To investigate the correlation between risk factors for coronary stenosis and the degree of coronary artery stenosis based on coronary computed tomography angiography (CCTA).

Methods: Two hundred seventy-eight patients with coronary artery disease who received treatment in our hospital between January 2020 and January 2021 were selected as the experimental group, and 100 healthy people who received physical examination in our hospital during the same period were selected as the control group (age and gender matched with the study group). The clinical data and CCTA data of the two groups of patients were collected and compared.

Photodegradation of the pure and formulated scoparone in liquid solutions: kinetics and mechanism.

Scoparone (hereafter SPR) is a prominent candidate of plant-derived acaricide. The photodegradation of the pure SPR was first investigated under different light sources, initial concentrations, pH values, temperatures, organic solvents, aqueous media, and the photolytic characteristics of its formulation in pure water were also studied. The photodegradation rates of pure SPR under different light sources showed the following sequence: 28 W ultraviolet lamp (0.

The diagnostic value of dynamic volume computed tomography angiography in children with anomalous origin of the left coronary artery from the pulmonary artery.

There have been almost no reports on the technique of dynamic volume computed tomography angiography (DVCTA) in children with anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA). Twelve children with ALCAPA, aged 5 months to 15 years, were enrolled in this retrospective study to explore the clinical value of DVCTA in the diagnosis of ALCAPA in children. All patients underwent low-dose prospective ECG-gated 320-slice DVCTA and transthoracic echocardiography.

Functional analysis of an upregulated calmodulin gene related to the acaricidal activity of curcumin against Tetranychus cinnabarinus (Boisduval).

Background: Curcumin is a promising botanical acaricidal compound with activity against Tetranychus cinnabarinus. Calmodulin (CaM) is a key calcium ion (Ca ) sensor that plays a vital role in calcium signaling. Overexpression of the CaM gene with inducible character occurs in curcumin-treated mites, but its functional role remains to be further analyzed by RNA interference (RNAi) and protein expression.

Molecular characterization of a voltage-gated calcium channel and its potential role in the acaricidal action of scopoletin against Tetranychus cinnabarinus.

The carmine spider mite, Tetranychus cinnabarinus (Boisduval), is a polyphagous agricultural pest with an extensive host plant range. Scopoletin is a promising acaricidal compound whose acaricidal mechanism may occur by disrupting intracellular Ca homeostasis and calcium signaling pathways. However, the underlying mechanism of scopoletin for specific target locations of T.

Analysis of the Physicochemical Properties of Acaricides Based on Lipinski's Rule of Five.

This study aimed to explore the similarity between the physical and chemical properties of different acaricides, determine whether Lipinski's Rule of Five (RO5) used in the design of drug molecules is suitable for screening acaricides, and provide methods for selection of new acaricides. We evaluated and predicted the molecular properties of >180 acaricides using Molinspiration. We calculated physicochemical property parameters, such as log , molecular weight (MW), and number of hydrogen bond donors (HBDs), hydrogen bond acceptors (HBAs), and rotatable bonds (Rot B).

Silencing T-type voltage-gated calcium channel gene reduces the sensitivity of Tetranychus cinnabarinus (Boisduval) to scopoletin.

Tetranychus cinnabarinus (Boisduval) is a major pest that harms crops and vegetables worldwide. Scopoletin is a promising acaricidal compound. Our previous study demonstrated that the acaricidal mechanism of scopoletin may be via disrupting intracellular Ca homeostasis and calcium signaling pathway.

Synthesis and Acaricidal Activities of Scopoletin Phenolic Ether Derivatives: QSAR, Molecular Docking Study and in Silico ADME Predictions.

Thirty phenolic ether derivatives of scopoletin modified at the 7-hydroxy position were synthesized, and their structures were confirmed by IR, ¹H-NMR, C-NMR, MS and elemental analysis. Preliminary acaricidal activities of these compounds against female adults of (Boisduval) were evaluated using the slide-dip method. The results indicated that some of these compounds exhibit more pronounced acaricidal activity than scopoletin, especially compounds , , , and which exhibited about 8.

3D-QSAR and Molecular Docking Studies on the TcPMCA1-Mediated Detoxification of Scopoletin and Coumarin Derivatives.

The carmine spider mite, (Boisduval), is an economically important agricultural pest that is difficult to prevent and control. Scopoletin is a botanical coumarin derivative that targets Ca-ATPase to exert a strong acaricidal effect on carmine spider mites. In this study, the full-length cDNA sequence of a plasma membrane Ca-ATPase 1 gene () was cloned.

Graphene Oxide Induces Toxicity and Alters Energy Metabolism and Gene Expression in Ralstonia solanacearum.

Graphene oxide (GO) is a promising material for development as an antibacterial, phytoprotective agent due to its contact-based antibacterial activity induced by its physical and chemical properties. However, the mechanism underlying the antibacterial effect of GO has yet to be elucidated. In the current study, we investigated the effects of GO on the phytopathogen R.

Synergistic inhibitory effect of scopoletin and bisdemethoxycurcumin on Tetranychus cinnabarinus (Boisduval) (Acari: Tetranychidae).

The study aimed to investigate the synergistic activity of scopoletin and bisdemethoxycurcumin (BDMC) against the carmine spider mite Tetranychus cinnabarinus. The acaricidal activities of mixtures of scopoletin and BDMC against T. cinnabarinus female adults were measured via slide dipping and leaf disc dipping.

[Lethal effects of scopoletin and bisdemethoxycurcumin against Tetranychus cinnabarinus Boisd. (Acari: Tetranychidae): a simulation study].

By using slide-dip bioassay method under laboratory condition, an investigation was made on the lethal effects of scopoletin, bisdemethoxycurcumin (BDMC), and their combination at an optimal mass ratio (7:6) of scopoletin to BDMC against the adult females of Tetranychus cinnabarinus Boisd. A time-dose mortality model (TDM) was established, which passed the Hosmer-Lemeshow test. The sensitivity of the adult females to the concentration change of the acaricides was in the sequence of scopoletin > optimal mass ratio of scopoletin to BDMC > BDMC.