Publications by authors named "Jinxian Yan"
Purpose: This study aimed to develop a model to predict the risk of axillary lymph node (ALN) metastasis in breast cancer patients, using gray-scale ultrasound and clinical pathological features.
Methods: A retrospective analysis of 212 breast cancer patients who met the inclusion criteria from January 2011 to December 2021 was carried out. Clinical and pathological characteristics, including age, tumor size, pathological type, molecular subtype, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and proliferation cell nuclear antigen (Ki-67), were examined.
Article Synopsis
- The study aimed to evaluate the effectiveness of multimodal ultrasound imaging in diagnosing ischemic heart failure (IHF) in rats, linking imaging results with tissue damage indicators.
- The experimental setup involved 30 male SD rats, with 20 subjected to IHF via artery ligation, leading to various echocardiographic and histological analyses.
- Results indicated significant cardiac function decline in the model group, evidenced by decreased ejection fraction and cardiac output, while histopathological studies revealed substantial cellular damage and changes in myocardial oxygen saturation.
Article Synopsis
- Jianxin (JX) granules are a traditional Chinese medicine used to treat heart failure (HF), and this study investigates their treatment mechanism using network pharmacology and in-vivo experiments.
- The research identified 122 active components, 896 drug targets, and 151 key targets related to HF, revealing important pathways and core hub genes such as IL-6 and VEGFA.
- In-vivo experiments confirmed that JX granules enhance cardiac function and reduce heart tissue damage by influencing specific biomarkers and pathways involved in HF.
Objective: To optimize extraction process of Fufang Bajitian Shenggu Particles by central composite design and response surface method.
Methods: The preparation of Fufang Bajitian Shenggu Particles was designed according to the test. With the overall desirability (OD) of Icariin content and the dry extract yield in medicinal materials extract concentrate as examining indexes, immersion time, material liquid ratio, extraction time and stress concentration temperature were investigated.