Publications by authors named "Jinxi Wei"
Article Synopsis
- - Triple-negative breast cancer has a "cold" microenvironment that resists current immunotherapy, but activating the STING pathway shows potential for improving treatment effectiveness.
- - The study combines photothermal therapy (PTT) using a semiconductor nano-agent (DPTT-Mn Lipo NPs) with innate immune responses to reprogram the immune-suppressive environment and enhance anti-tumor immunity.
- - This approach not only triggers cell death and activates immune cells but also works well with anti-PD-1 therapy to create lasting immune memory, helping to prevent tumor recurrence.
Article Synopsis
- Targeted cancer therapies are more precise and effective but currently have limited applicability due to a lack of suitable tumor targets among patients.!* -
- The study explores using calreticulin (CALR), an immunogenic cell death marker, as a potential target for therapy by engineering probiotic EcN 1917 with a specific nanobody (Nb215) that binds to CALR.!* -
- Results show that CALR-targeted EcN-215 combined with photothermal therapy (PTT) can enhance immune cell infiltration in tumors and improve anticancer effects, suggesting CALR-targeted strategies could treat various cancers effectively.!*
Objective: To explore the application value of color Doppler ultrasonography combined with thyroid autoantibody tests in the early diagnosis of thyroid cancer.
Methods: The medical data of 100 patients with thyroid nodules treated in our hospital from June 2019 to June 2021 were retrospectively analyzed; all patients received color Doppler ultrasonography and thyroid autoantibody tests before surgery and were divided into the benign lesion group ( = 45) and the malignant lesion group ( = 55) according to the postoperative pathological findings (the gold standard), so as to compare and analyze the application value of color Doppler ultrasonography, thyroid autoantibody tests, and their combination in the early diagnosis of thyroid cancer.
Results: Compared with the pathological findings, the accuracy rate, sensitivity, specificity, positive predictive value, and negative predictive value of the combined diagnosis were significantly higher than those in the single diagnosis of color Doppler ultrasonography, TgAb test, TPOAb test, and TRAb test ( < 0.
Background: Roxadustat has been shown effective in treating patients with anemia due to chronic kidney disease. However, its long-term effect on clinical outcomes and socioeconomic burden and safety remains unclear.
Methods/design: This is a multicenter, prospective, longitudinal observational cohort study assessing if Roxadustat improves prognosis in dialysis patients.