Publications by authors named "Jinwen Xian"
Article Synopsis
- Cystic echinococcosis, caused by Echinococcus granulosus, is a serious zoonotic disease with no current vaccine available for its canine hosts, making disease management critical.
- This study focused on developing a DNA vaccine using the EgM123 antigen, which is known to provoke a strong immune response against the infection in dogs.
- Results demonstrated that the pVAX1-EgM123 DNA vaccine significantly increased IgG levels, boosted essential cytokines, and reduced worm burden by 87.85%, suggesting its potential effectiveness in controlling echinococcosis in canines.
Cystic echinococcosis (CE) is a cosmopolitan zoonosis caused by the larval stage of , which affects humans and a wide range of mammalian intermediate hosts. Parasite tetraspanin proteins are crucial for host-parasite interactions, and therefore they may be useful for vaccine development or disease diagnosis. In the present study, the major antigen coding sequence of tetraspanin 11 (Eg-TSP11) from was determined.
View Article and Find Full Text PDFBackground: Cystic echinococcosis (CE) is a serious parasitic zoonosis caused by the larvae of the tapeworm Echinococcus granulosus. The development of an effective vaccine is one of the most promising strategies for controlling CE.
Methods: The E.
() parasitizes the small intestine of sheep and causes inhibited growth and development or even death. Being globally distributed, it causes considerable economic losses to the animal husbandry industry. Here, using Illumina, PacBio and BioNano techniques, we obtain a high-quality genome assembly of , which has a total length of 142 Mb, a scaffold N50 length of 7.
View Article and Find Full Text PDF