Reshaping the tumor immune microenvironment to improve CAR-T cell-based cancer immunotherapy.

In many hematologic malignancies, the adoptive transfer of chimeric antigen receptor (CAR) T cells has demonstrated notable success; nevertheless, further improvements are necessary to optimize treatment efficacy. Current CAR-T therapies are particularly discouraging for solid tumor treatment. The immunosuppressive microenvironment of tumors affects CAR-T cells, limiting the treatment's effectiveness and safety.

Smartphone Imaging Device for Multimodal Detection of Hydrogen Sulfide Using Cu-Doped MOF Sensors.

Multimodal sensing platforms may offer reliable, fast results, but it is still challenging to incorporate biosensors with high discriminating ability in complex biological samples. Herein, we established a highly sensitive dual colorimetric/electrochemical monitoring approach for the detection of hydrogen sulfide (HS) utilizing Cu-doped In-based metal-organic frameworks (Cu/In-MOFs) combined with a versatile color selector software-based smartphone imaging device. HS can result in the enhancement of the electrochemical signal because of the electroactive substance copper sulfide (CuS), the decrease of the colorimetric signal of the characteristic absorption response caused by the strong coordination effect on Cu/In-MOFs, and the obvious changes of red-green-blue (RGB) values of images acquired via an intelligent smartphone.

Electrochemical sensor for hydrogen sulfide detection using electrocatalysis-assisted amplification and chemical reaction-mediated signal enhancement.

An ultrasensitive electrochemical biosensing platform has been designed by combining electrocatalysis-assisted HS amplification with a chemical reaction-mediated electrochemical signal-boosted system for HS detection based on Cu-Mn(OH) hexagonal nanorings. The signal amplification is initiated by an electrocatalysis reaction that can grasp specific HS substrates and further highly amplify electrochemical signals. Then, the unique chemical reaction is powered by copper ion and generates a large amount of electroactive CuS products on the electrode surface, thus achieving the multiple amplification of HS detection.

Genome-Wide Identification and Characterization of Potato Long Non-coding RNAs Associated With Resistance.

Long non-coding RNA (lncRNA) is a crucial regulatory mechanism in the plant response to biotic and abiotic stress. However, their roles in potato ( L.) resistance to () largely remain unknown.