Arsenic inducible islet β-cell dysfunction and ferroptosis through mA-YTHDF2-dependent CHAC1 enhancement.

Arsenic, recognized as an environmental and food contaminant, has been linked to the dysfunction of islet β-cells, the primary lesions in type 2 diabetes (T2D). Ferroptosis, a regulated cell death pathway dependent on GPX4, has been implicated in arsenic-induced β-cell dysfunction. However, the underlying molecular mechanisms remain unclear.

Overview of Meta-Analyses on Naturalistic Developmental Behavioral Interventions for Children with Autism Spectrum Disorder.

We conducted an overview of reviews to determine the effects of naturalistic developmental behavioral interventions (NDBIs; Schreibman et al. (2015) J Autism Dev Disorders 45:2411-2428) on children with autism spectrum disorder under 8 years old. We conducted an electronic database search of Academic Search Premier, CINHAL, ERIC, Medline, and APA PsycINFO in October 2022 and August 2023 and utilized snowball methods to locate relevant reviews of NDBI.

mA methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.

Arsenic exposure has been closely linked to hepatic insulin resistance (IR) and ferroptosis with the mechanism elusive. Peroxisome proliferator γ-activated receptor coactivator 1-α (PGC-1α) is essential for glucose metabolism as well as for the production of reactive oxygen species (ROS). However, it was unclear whether there is a regulatory connection between PGC-1α and ferroptosis.

Efficient, Robust, and Flame-Retardant Electrothermal Coatings Based on a Polyhedral Oligomeric Silsesquioxane-Functionalized Graphene/Multiwalled Carbon Nanotube Hybrid with a Dually Cross-Linking Structure.

Graphene electrothermal coatings have attracted considerable attention in recent years due to their important application prospects in a broad range of areas. So far, lots of strategies have been explored for producing them. However, these strategies usually involve a complicated process with sophisticated conditions, limiting their scalable applications.

Efficient exfoliation of UV-curable, high-quality graphene from graphite in common low-boiling-point organic solvents with a designer hyperbranched polyethylene copolymer and their applications in electrothermal heaters.

The use of stabilizer with designer structures can effectively promote graphite exfoliation in common solvents to render functionalized graphene desirable for their various applications. Herein, a hyperbranched polyethylene copolymer, HBPE@Py@Acryl, simultaneously bearing multiple pyrene terminal groups and pendant acryloyl moieties has been successfully synthesized from ethylene with a Pd-diimine catalyst based on unique chain walking mechanism. The unique structural design of the HBPE@Py@Acryl makes it capable of effectively promote graphite exfoliation in a series of common, low-boiling-point organic solvents, e.

Improving the adsorption capacity for ovalbumin by functional modification of aminated mesoporous silica nanoparticles with tryptophan.

Tryptophan (Trp) modified aminated mesoporous silica nanoparticles (AMSNs), shortened to Trp-AMSNs, are prepared via covalent binding. The obtained Trp-AMSNs exhibit a uniform size of ca. 83 nm, a mesopore diameter of ca.