Publications by authors named "Jinwei Quan"
Article Synopsis
- Dilated cardiomyopathy (DCM) is a serious heart condition linked to high mortality rates, and mutations in the lamin A/C gene are a common cause, with few treatment options available.
- Researchers created a mouse model with this mutation and observed cardiac dysfunction starting at one month old, along with mitochondrial damage and reduced SIRT1 levels in younger hearts.
- Overexpressing SIRT1 improved mitochondrial function and reduced heart damage, suggesting that targeting the SIRT1 pathway could offer new treatment possibilities for DCM related to lamin A/C mutations.
Background: There are controversies on the pathophysiological alteration in patients with atrial fibrillation (AF) undergoing pulmonary vein isolation using different energy sources.
Objectives: We evaluated the changes in plasma proteins in acute phase post-ablation in patients receiving cryoballoon ablation, radiofrequency balloon ablation, or radiofrequency ablation.
Methods: Blood samples from eight healthy controls and 24 patients with AF were taken on the day of admission, day 1, and day 2 post-ablation and analyzed by the Olink proximity extension assay.
Emerin is an inner nuclear envelope protein encoded by the EMD gene, mutations in which cause Emery-Dreifuss muscular dystrophy type 1 (EDMD1). Cardiac involvement has become a major threat to patients with EDMD1; however, the cardiovascular phenotype spectrums of emerinopathy and the mechanisms by which emerin regulates cardiac pathophysiology remain unclear. Here, we identified a novel nonsense mutation (c.
View Article and Find Full Text PDFTo explore immune-related feature genes in patients with dilated cardiomyopathy (DCM). Expression profiles from three datasets (GSE1145, GSE21610 and GSE21819) of human cardiac tissues of DCM and healthy controls were downloaded from the GEO database. After data preprocessing, differentially expressed genes (DEGs) were identified by the 'limma' package in R software.
View Article and Find Full Text PDFBackground: Data comparing dabigatran with rivaroxaban regarding the resolution of left atrial/left atrial appendage (LA/LAA) thrombus in patients with nonvalvular atrial fibrillation (AF) are scarce. This study aimed to compare the efficacy and safety of dabigatran vs rivaroxaban regarding the resolution of LA/LAA thrombus in patients with nonvalvular AF.
Methods: This retrospective study enrolled nonvalvular AF patients scheduled to undergo catheter ablation or cardioversion in Shanghai Ruijin Hospital between January 2014 and January 2019.