Background And Aims: Sex determining region Y related high-mobility group box protein 9 (Sox9) is expressed in a subset of hepatocytes, and it is important for chronic liver injury. However, the roles of Sox9 hepatocytes in response to the acute liver injury and repair are poorly understood.
Methods: In this study, we developed the mature hepatocyte-specific Sox9 knockout mouse line and applied three acute liver injury models including PHx, CCl and hepatic ischemia reperfusion (IR).