Publications by authors named "Jinwei He"

Article Synopsis
  • The hydrolysis step of 2,7-epoxy is crucial for the production of camptothecin (CPT), a compound with potent cancer-fighting properties, yet the specific genes involved have not been previously identified.
  • This study identifies three genes (CaEH1-CaEH3) responsible for the epoxide hydrolase activity in Camptotheca acuminata and highlights their ability to catalyze the opening of various oxirane rings.
  • Functional tests show that these genes are actively involved in CPT biosynthesis, are expressed in all plant tissues with a concentration in leaves, and suggest a convergence in their evolutionary development from different ancestral genes.
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  • - The study explored how exposure to air pollutants like 2.5-micrometer Particulate Matter (PM), Sulfur Dioxide (SO), Nitrogen Dioxide (NO), and Ozone during the first trimester affects the likelihood of spontaneous abortions in pregnant women.
  • - Researchers conducted a retrospective analysis comparing clinical data from women who experienced spontaneous abortions and those with full-term pregnancies, using two different methods to assess pollutant exposure.
  • - Findings suggest that exposure to pollutants, particularly PM, SO, and NO during the first trimester, is associated with an increased risk of spontaneous abortion, with both assessment methods yielding consistent correlation results.
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Euryale ferox was chosen for this study to examine its mechanical properties during chewing. Experiments and the discrete element method were used to conduct the study. Initially, the intrinsic and contact parameters of E.

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Objective: To investigate the association between exposure to atmospheric pollutants and preterm birth in a river valley-type city and its critical exposure windows.

Methods: A retrospective cohort study was used to collect data from the medical records of preterm and full-term deliveries in two hospitals in urban areas of a typical river valley-type city from January 2018 to December 2019. A total of 7,288 cases were included in the study with general information such as pregnancy times, the number of cesarean sections, occupation, season of conception and regularity of the menstrual cycle.

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Developing carbon-supported Pt-based electrocatalysts with high activity and long-durability for the oxygen reduction reaction (ORR) is an enormous challenge for their commercial applications due to the corrosion of carbon supports in acid/alkaline solution at high potential. In this work, a Janus structural TaON/graphene-like carbon (GLC) was synthesized via an in-situ molecular selfassembly strategy, which was used as a dual-carrier for platinum (Pt). The as-obtained Pt/TaON/GLC presents high half-wave potential (0.

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  • The study aimed to investigate the impact of air pollutants on preterm births and changes in blood cell counts in mothers from 2018 to 2020 in Baota District, Yan'an City.
  • Researchers collected air quality data and meteorological information to analyze the effects of pollutants like PM, SO, NO, CO, and O on preterm births using statistical methods.
  • The findings indicated that exposure to certain air pollutants is associated with an increased risk of preterm birth and changes in blood cell counts, with specific pollutants showing both long-term and cumulative effects.
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  • - Recent research has clarified the chemical process for flavonol production in the plant Camptotheca acuminata, but the specific genes responsible for its methylation are still not fully understood.
  • - Two important genes, CaFOMT1 and CaFOMT2, were identified as key players in this process, with CaFOMT1 specifically methylating the 4'-OH group of quercetin and CaFOMT2 acting on both the 4'-OH and 7-OH groups.
  • - Analysis of their molecular structure revealed specific sites essential for their function, while also indicating that these genes evolved separately from a different lineage than previously identified methyltransferases.
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Objective: Pollutants in the atmosphere have been linked to poor pregnancy outcomes in women. However, such investigations are scarce in metropolitan northern China. The major exposure window of air pollution affecting pregnant women is also unknown.

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Dozens of triterpenes have been isolated from Camptotheca acuminata, however, triterpene metabolism in this plant remains poorly understood. The common C28 carboxy located in the oleanane-type and ursane-type triterpenes indicates the existence of a functionally active triterpene, C28 oxidase, in this plant. Thorough mining and screening of the CYP716 genes were initiated using the multi-omics database for C.

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Low crystalline photocatalysts with unsaturated active sites, such as oxygen vacancy (O ), is reported to exhibit enhanced adsorption and activation of oxygen-containing small molecules, such as H O and CO , thus boosting the activity in photocatalytic H evolution and CO reduction. However, numerous low-crystalline photocatalysts show unsatisfactory stability due to the easily repaired surface O . Herein, three SnNb O with different crystallinity were prepared by hydrothermal approach with similar precursors.

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Hexokinase1 (HXK1) is a bifunctional enzyme that plays indispensable roles in plant growth, nitrogen utilization, and stress resistance. However, information on the HXK family members of strawberries and their functions in glucose sensing and metabolic regulation is scarce. In the present study, four HXKs were firstly identified in the genome of and .

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Background: Dyslipidemia is a key factor causing cardio cerebrovascular diseases, and the total cholesterol (TC) is an important lipid indicator among them. Studies have shown that environmental factors have a strong association with TC levels. Previous studies only focused on the seasonal variation of TC level and the short-term effects of some environmental factors on TC level over time, and few studies explored the geographical distribution of TC level and quantified the impact of environmental factors in space.

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  • * Methods: A total of 65 patients with knee osteoarthritis were monitored, evaluating pain and function using various scoring systems, and measuring inflammatory markers and collagen levels in joint fluid and serum over a follow-up period.
  • * Results: Six months post-surgery, patients showed significant improvements in pain levels and knee function scores, alongside a decrease in inflammatory markers and collagen breakdown products, indicating a positive impact on joint health and cartilage maintenance.
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  • Huanglongbing (HLB) is a serious disease affecting the citrus industry, with no resistant citrus varieties available, but some show tolerance to the disease.
  • The study focused on the 'Pujiang Xiangcheng' rootstock and its physiological and metabolic responses to infection by the HLB-causing agent, Liberibacter asiaticus (CLas), revealing some damage to summer flushes and roots after 15 weeks.
  • Key findings included compromised chlorophyll and photosynthetic rates, active starch breakdown in roots, and changes in fatty acid content, providing valuable insights into how this rootstock interacts with the pathogen during the early stages of HLB infection.
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The aim of this study was to explore the allelic association between genetic polymorphisms of the NF-κB pathway and the variance of clinical effects of zoledronic in postmenopausal Chinese women with osteoporosis. In the study, 110 Chinese postmenopausal women with osteoporosis were recruited. Every patient received zoledronic once a year.

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Background: We use longitudinal chest CT images to explore the effect of steroids therapy in COVID-19 pneumonia which caused pulmonary lesion progression.

Materials And Methods: We retrospectively enrolled 78 patients with severe to critical COVID-19 pneumonia, among which 25 patients (32.1%) who received steroid therapy.

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Preterm birth (PTB) has been associated with exposure to air pollution, but it is unclear whether effects might vary among air pollution sources in a valley city, and yet few studies have investigated refined susceptible windows for PTB. We performed a retrospective birth cohort study in Yan'an city, a typical valley city in the west of China, and analyze the effects of air pollutants on premature delivery, identify critical windows for maternal air pollutants exposure and PTB. The pregnant women who gave birth in the Affiliated Hospital of Yan'an University and Yan'an people's Hospital from January 1, 2018 to December 31, 2019 were selected as the research objects.

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Background: Blood lipid is an important factor affecting cardiovascular disease in middle-aged and elderly people. At present, the associations between environmental factors and blood lipid level in elderly people has been controversial, and the nonlinear effect of their relationship is lack of research.

Methods: This study used data from a national cross-sectional survey of blood lipid levels in 13,354 subjects and data from environmental monitoring sites.

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  • The study investigates how geographical factors influence normal TSH (thyroid stimulating hormone) values in healthy Chinese adults by analyzing data from 9321 individuals across 120 cities.
  • Researchers found significant correlations between TSH levels and 24 geographical variables, identifying 11 key factors through correlation analysis.
  • The results indicate that TSH levels are generally higher in northern and western regions of China, while lower values are found in southern and eastern areas, demonstrating the impact of climate, topography, and soil on hormone regulation.
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  • The study explored the link between steroid therapy and lung damage measured by quantitative CT (QCT) in 72 severe COVID-19 patients over time.
  • Results showed that patients receiving steroids had a significant decrease in compromised lung volume after stage 3 of hospitalization, particularly in those with higher initial lung damage.
  • The findings suggest steroids can be beneficial in reducing lung impairment in COVID-19 patients but their effectiveness may depend on the duration of treatment and the severity of lung compromise at the start.
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Purposes: In order to investigate the association between serum periostin levels and the variation of its encoding gene and the prevalence of vertebral fractures and bone mineral density (BMD) in Chinese postmenopausal women, an association study was performed.

Materials And Methods: 385 postmenopausal women were recruited. For participants without a history of vertebral fracture, lateral X-rays of the spine covering the fourth thoracic spine to the fifth lumbar spine were performed to detect any asymptomatic vertebral fractures.

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We demonstrated previously that there is a correlation between glucagon-like peptide-1 (GLP-1) single-nucleotide polymorphism (SNP) and bone mineral density in postmenopausal women. Both GLP-1 and glucose-dependent insulinotropic peptide are incretins. The glucose-dependent insulinotropic peptide receptor (GIPR) SNP rs10423928 has been extensively studied.

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Objective: The current study was conducted to determine whether peak bone mineral density (BMD) and obesity phenotypes are associated with certain gene polymorphisms found in Chinese nuclear families with female children.

Methods: A total of 22 single nucleotide polymorphisms (SNPs) located in and around the gene were identified in 1,300 subjects who were members of 390 Chinese nuclear families with female children. Then, BMD readings of the femoral neck, total hip, and lumbar spine as well as measurements of the total lean mass (TLM), total fat mass (TFM), and trunk fat mass were obtained dual-energy X-ray absorptiometry.

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Purpose: GWAS has successfully located and analyzed the pathogenic genes of osteoporosis. Genetic studies have found that heritability of BMD is 50%-85% while the other half is caused by hip geometric parameters and tissue horizontal characteristics. This study was designed to study the GWAS of osteoporosis in Shanghai Han population.

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Article Synopsis
  • This study investigates the relationship between GLP-1 receptor gene variations (SNPs) and bone mineral density (BMD) in postmenopausal women in Shanghai.
  • Out of eight SNPs analyzed, the A/A genotype of rs2295006 showed a negative correlation with BMD in the lumbar spine and the A allele was linked to lower hip BMD.
  • The findings suggest that the rs2295006 SNP may influence bone health in postmenopausal women, while other SNPs studied did not show a significant effect on BMD.
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