The secondary near-infrared region (NIR-II) fluorescence imaging-guided photothermal therapy (PTT) offers a noninvasive and light-controllable treatment option for deep-seated cancers. However, the development of NIR-II photothermal agents (NIR-II PTAs) that possess the desired properties of high molar absorption coefficient (ε), fluorescence quantum yield (QY), and photothermal conversion efficiency (PCE) remain a challenge due to the contradiction between radiative and nonradiative processes. Herein, we propose a novel side-chain heteroatom substitution engineering strategy to simultaneously enhance ε, QY, and PCE by modifying the molecular planarity.
View Article and Find Full Text PDFThe mammalian brain has an extremely limited ability to regenerate lost neurons and to recover function following ischemic stroke. A biomaterial strategy of slowly-releasing various regeneration-promoting factors to activate endogenous neurogenesis represents a safe and practical neuronal replacement therapy. In this study, basic fibroblast growth factor (bFGF)-Chitosan gel is injected into the stroke cavity.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
February 2025
Electrocatalytic reduction of NO is a green and sustainable method that not only helps to treat industrial pollutants in wastewater, but also produces valuable chemicals. However, the slow dynamics of the proton-coupled electron transfer process results in a high barrier and low conversion efficiency. In this work, the Se-deficient FeSe/FeO heterojunction was synthesized, which showed excellent electrochemical performance in 0.
View Article and Find Full Text PDFContext: High-energy density materials (HEDMs) are integral to modern society and are in high demand. Consequently, the design and synthesis of energetic material molecules have garnered significant research interest. This study focuses on the furazan ring system as a core for developing superior HEDMs.
View Article and Find Full Text PDFAs a simulant of hazardous Ra, the simultaneously selective and rapid elimination of radioactive Ba ions from geothermal water is necessary but still challenging. In this paper, we demonstrated the usability of a layered thiostannate with facile synthesis and inexpensive cost, namely, KSnS (KTS-3, = 0.65-1), for the remediation of radioactive Ba in multiple conditions, including sorption isotherm, kinetics, and the influences of competitive inorganic/organic ions, pH values, and dosages.
View Article and Find Full Text PDFDual-atom site catalysts (DASCs) have sparked considerable interest in heterogeneous photocatalysis as they possess the advantages of excellent photoelectronic activity, photostability, and high carrier separation efficiency and mobility. The DASCs involved in these important photocatalytic processes, especially in the photocatalytic hydrogen evolution reaction (HER), CO reduction reaction (CORR), N/nitrate reduction, ., have been extensively investigated in the past few years.
View Article and Find Full Text PDFHerein, amorphous/crystalline Fe-doped CoSe was synthesized (Fe-CoSe/NF), and it exhibited high oxygen evolution reaction (OER) performance. The synergistic effect of the Fe dopant and the amorphous/crystalline structure is conducive to the formation of high valence Co and Fe active sites. Fe-CoSe/NF shows low overpotentials of 269 mV@50 mA cm and 280 mV@100 mA cm.
View Article and Find Full Text PDFHydrogen peroxide (HO) is a highly value-added and environmental-friendly chemical with various applications. The production of HO by electrocatalytic 2e oxygen reduction reaction (ORR) has emerged as a promising alternative to the energy-intensive anthraquinone process. High selectivity Catalysts combining with superior activity are critical for the efficient electrosynthesis of HO.
View Article and Find Full Text PDFα-Solanine has been shown to exhibit anti-inflammatory and anti-tumour properties; however, its efficacy in treating osteoarthritis (OA) remains ambiguous. The study aimed to evaluate the therapeutic effects of α-solanine on OA development in a mouse OA model. The OA mice were subjected to varying concentrations of α-solanine, and various assessments were implemented to assess OA progression.
View Article and Find Full Text PDFThe explorations of new three-dimensional (3D) microporous metal halides, especially the iodoargentate-based hybrids, and understanding of their structure-activity relationships are still quite essential but full of great challenges. Herein, with the aromatic 4,4'-dpa (4,4'-dpa = 4,4'-dipyridylamine) ligands as the structural directing agents, we solvothermal synthesized and structurally characterized a novel member of microporous iodoargentate family, namely [H-4,4'-dpa]AgI (). Compound possesses a unique and complicated 3D [AgI] anionic architecture that was built up from the unusual hexameric [AgI] secondary building units (SBUs).
View Article and Find Full Text PDFIn order to study the interaction between composite photocatalytic material TiO@LDO and matrix asphalt, the four-component 12 molecular structure model of 70# matrix asphalt was optimized by using software Materials Studio 2020, and its heterostructure with TiO@LDO composite was modeled. The bonding performance between asphalt and composite photocatalytic material was analyzed by interface energization, and the diffusion performance between asphalt and composite photocatalytic material was analyzed from the perspectives of particle movement and Z-direction density. By changing the temperature and other parameters in the simulation process, the change in bonding strength between TiO@LDO and asphalt was investigated.
View Article and Find Full Text PDFAdsorption and photocatalysis are effective in removing organic pollutants from wastewater. This study is based on the memory effects of MgAl-layered double hydroxides (MgAl-LDHs) after high-temperature calcination. By introducing bismuth vanadate (BiVO) during the reformation of the layered structure via contact with water, a composite material BiVO/MgAl-LDHs with enhanced adsorption and visible light catalytic performance was synthesized.
View Article and Find Full Text PDFThe separator is an important component in lithium-sulfur (Li-S) batteries. However, the conventional polypropylene (PP) separators have the problem of easy shuttling of lithium polysulfide (LiPSs). Herein, ultrathin magnesium boride (MgB) nanosheets were prepared by ultrasonic-assisted exfoliation technology, and were suction-filtered onto a separator to serve as a separator modification layer.
View Article and Find Full Text PDFObjectives: This study aimed to screen the potential risk factors for academic burnout among adolescents during the COVID-19 pandemic, develop and validate a predictive tool based on the risk factors for predicting academic burnout.
Design: This article presents a cross-sectional study.
Setting: This study surveyed two high schools in Anhui Province, China.
Pursuits of new types of Pb-free heterometallic halides adequate for photovoltaic applications are still urgent but challenging. In this study, by using -produced [(Me)-(DABCO)] (DABCO = 1,4-diazabicyclo[2.2.
View Article and Find Full Text PDFBackground: Childhood systemic lupus erythematosus (cSLE) is a multisystemic, life-threatening autoimmune disease. Compared to adults, SLE in childhood is more active, can cause multisystem involvement including renal, neurological and hematological, and can cause cumulative damage across systems more rapidly. Autophagy, one of the core functions of cells, is involved in almost every process of the immune response and has been shown to be associated with many autoimmune diseases, being a key factor in the interplay between innate and adaptive immunity.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
December 2022
Methods: In this study, we developed a strategy for the prevention and therapy of melanoma using a whole-cell vaccine combined with a CpG/αOX40/cGAMP triple adjuvant. The CpG/αOX40/cGAMP triple adjuvant was used to co-culture melanoma cells in vitro to induce immunogenic death of tumor cells. The mixture of inactivated tumor cells and the triple drug was an optimized tumor whole-cell vaccine, which was injected subcutaneously into mice for tumor prevention and therapy.
View Article and Find Full Text PDFFront Behav Neurosci
May 2022
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that can lead to severe social behavioral difficulties, which mainly manifests as social communication and interaction disorders; narrow interests; and repetitive, stereotyped behaviors. In recent years, the prevalence of ASD has increased annually, and it has evolved from a rare disease to one with a high incidence among childhood developmental disorders. The pathogenesis of ASD is considered to be the interaction of genetic and environmental factors.
View Article and Find Full Text PDFClear cell renal cell carcinoma (ccRCC) is one of the most aggressive malignancies in humans. Hypoxia-related genes are now recognized as a reflection of poor prognosis in cancer patients with cancer. Meanwhile, immune-related genes play an important role in the occurrence and progression of ccRCC.
View Article and Find Full Text PDFGPR120 is implicated in the regulation of glucose and lipid metabolism, and insulin resistance. In the current study, we aimed to investigate the role of GPR120 in polycystic ovary syndrome (PCOS). With the adoption of dehydroepiandrosterone, a rat model was established to simulate PCOS in vitro.
View Article and Find Full Text PDFA series of bridged tetrazine derivatives (BDDT) were designed by using different bridges to connect two molecules of 1,2,4, 5-tetrazine oxides and then combining different substituents. At the same time, we used DFT-wB97/6-31 + G** method to regularly predict the HOMO-LUMO, heats of formation (HOF), detonation properties, thermal stability, and thermodynamic property orbitals of BDDT compounds. By studying the comprehensive relationship between different substituents and bridging and performance, it is shown that -N(NO) and -C(NO) are not only excellent groups to improve the heat of formation and detonation properties, but also can cause the compound to have a superior oxygen balance.
View Article and Find Full Text PDFCancer Manag Res
November 2021
Purpose: Inflammatory biomarkers and clinical pathological factors have been reported to predict survival of patients with non-small cell lung cancer (NSCLC). The goal of this study was to identify risk factors for early recurrence in patients with pIIIA-N2 NSCLC who had undergone radial resection.
Methods: A retrospective analysis was conducted on 238 patients with pIIIA-N2 NSCLC who underwent surgical treatment at the First Affiliated Hospital of Wenzhou Medical University between December 2006 and August 2018.
Cancer Immunol Immunother
July 2022
Recently, the emergence of immunotherapy has revolutionized traditional tumour treatment. However, effective treatments for patients exhibiting αPD-1 resistance are still lacking. In our study, a combination of cytosine-phosphate-guanine oligodeoxynucleotides (CpG-ODNs), anti-OX40 and cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) injection in situ systematically generated a robust antitumour immune response in TC1 and B16 cells, which are αPD-1-resistant malignancies.
View Article and Find Full Text PDFBackground: San-Huang-Chai-Zhu formula (SHCZF) has been used to improve cholestasis for many years. This study aims to predict the possible gene targets of SHCZF in treating acute intrahepatic cholestasis (AIC) in rats.
Materials And Methods: Eighteen SD rats were randomly assigned to the normal group, ANIT group, and ANIT + SHCZF group.