High-throughput computational screening of auxetic two-dimensional metal dichalcogenides and dihalides.

Auxetic materials hold tremendous potential for many advanced applications, but candidates are quite scarce, especially at two dimensions. Here, we focus on two-dimensional (2D) metal dichalcogenides and dihalides with the chemical formula MX2 by screening structures sharing the P4̄m2 space group among 330 MX2 compounds from the computational 2D materials database. Via high-throughput first-principles computations, 25 stable MX2 (M = Mg, Ca, Mn, Co, Ni, Cu, Zn, Ge, Cd, Sn; X = F, Cl, Br, I, O, S, Se) systems with in-plane negative Poisson's ratios (NPRs) are successfully identified.

Stiffening of the Cytoplasm in Response to Intracellularly Applied Forces.

Cells constantly encounter mechanical forces that regulate various cellular functions, such as migration, division, and differentiation. Understanding how cells respond to forces at the intracellular level is essential for elucidating the mechanical adaptability of living cells. This study investigates how the cytoplasm alters its mechanical properties in response to forces applied inside a cell.

Analysis of the safety and efficacy of the self-pulling and latter transected technique in modified overlap anastomosis in total laparoscopic total gastrectomy.

Background: Laparoscopic total gastrectomy plus lymph node dissection is an effective treatment method for patients with gastric cancer. With the development and popularization of laparoscopic techniques in recent years, surgeons have become more skilled in laparoscopic techniques. Totally laparoscopic total gastrectomy (TLTG) has been developed; however, digestive tract reconstruction remains difficult, especially with anastomosis of the esophagus and jejunum.

Short- and long-term outcomes of Roux-en-Y and Billroth II with Braun reconstruction in total laparoscopic distal gastrectomy: a retrospective analysis.

Background: The controversy surrounding Roux-en-Y (R-Y) and Billroth II with Braun (BII + B) reconstruction as an anti-bile reflux procedure after distal gastrectomy has persisted. Recent studies have demonstrated their efficacy, but the long-term outcomes and postoperative quality of life (QoL) among patients have yet to be evaluated. Therefore, we compared the short-term and long-term outcomes of the two procedures as well as QoL.

METTL3-mediated mA methylation of PYGB facilitates pancreatic ductal adenocarcinoma progression through the activation of NF-κB signaling.

Brain Type Glycogen Phosphorylase (PYGB) has been revealed to participate in the progression of multiple human cancers. Nevertheless, the clinical significance and biological function of PYGB in pancreatic ductal adenocarcinoma (PAAD) remains unclarified. This study first analyzed the expression pattern, diagnostic value, and prognostic significance of PYGB in PAAD using the TCGA database.

Formation of Ohmic contacts between ferromagnetic CrGeTeand two-dimensional metals.

As a ferromagnetic semiconductor, two-dimensional (2D) CrGeTeholds significant implications for electronic and spintronic devices. To achieve 2D electronics, it is essential to integrate CrGeTewith 2D electrodes to form Schottky-barrier-free Ohmic contacts with enhanced carrier injection efficiency. Herein, by using first-principles calculations based on density-functional theory, we systematically investigate the structural, energetic, electronic and magnetic properties of 2D heterojunctions by combining CrGeTewith a series of 2D metals, including graphene, ZrCl, NbS, TaS, TaSe, ZnC, HgC, and ZrN.

Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes.

Glioblastoma (GBM) is the most common and aggressive primary brain cancer. Despite multimodal treatment including surgery, radiotherapy, and chemotherapy, median patient survival has remained at ~15 months for decades. This situation demands an outside-the-box treatment approach.

Exploring the impacts of economic policy uncertainty, natural resources, and energy structure on ecological footprints: evidence from G-10 nations.

The role of energy and natural resources rent has been studied in the literature but very few research works investigated the impacts of economic policy uncertainty and energy structure on ecological footprints (EFs) in the group of ten G-10 countries. Therefore, this research is designed to probe the impacts of economic policy uncertainty (EP), natural resources rent, energy structure, economic growth, and total factor productivity on EF. The annual data for 1995-2018 is analyzed by adopting second-generation methods.

Construction of Macroporous CoSnO with Hollow Skeletons as Anodes for Lithium-Ion Batteries.

Increasing the energy density of lithium-ion batteries (LIBs) can broaden their applications in energy storage but remains a formidable challenge. Herein, with polyacrylic acid (PAA) as phase separation agent, macroporous CoSnO with hollow skeletons was prepared by sol-gel method combined with phase separation. As the anode of LIBs, the macroporous CoSnO demonstrates high capacity retention (115.

Comprehensive Genomic and Epigenomic Analyses on Transcriptomic Regulation in Stomach Adenocarcinoma.

DNA methylation (MET)-mediated transcriptomic disturbance and copy number variations (CNVs) exert a significant influence in stimulating the heterogeneous progression of stomach adenocarcinoma (STAD). Nevertheless, the relation of DNA MET with CNVs, together with its impact on tumor occurrence, is still unclear. The messenger RNA (mRNA) expression (EXP) profiles, DNA MET, and DNA copy numbers, together with STAD mutation data, were collected from the TCGA official data portal.

Prognostic and immunological value of in breast cancer: implications for SARS-CoV-2.

Abnormal ATPase H+ Transporting Accessory Protein 1 () expression may promote carcinogenesis. We investigated the association of with breast cancer (BC) and COVID-19. The Oncomine, Gene Expression Profiling Interactive Analysis, Human Protein Atlas and Kaplan-Meier plotter databases were used to evaluate the expression and prognostic value of in BC.

Preparation of a novel double crosslinked chitin aerogel via etherification with high strength.

In this study, we introduced a novel double crosslinked chitin aerogel via etherification with EGDE for mechanical reinforcement. Samples with different EGDE: chitin weight ratios from 0 to 1.5:1 were fabricated through chitin dissolution in KOH/urea aqueous solution, ethanol neutralization and washing, and supercritical CO drying.

The beneficial role of Asian-based RecurIndex test in the prognostic prediction in Chinese male breast cancer patients.

RecurIndex, a multigene profiling assay, can predict the risk of local recurrence and distant metastasis in female breast cancer (FBC), but its role in male breast cancer (MBC) remains unclear. In this study, the clinicopathological data of 43 consecutive MBC patients undergoing surgeries between 2009 and 2018 were retrospectively analysed. Their paraffin-embedded tissue sections were examined by RecurIndex test which comprised 2 models: recurrence index for local recurrence (RI-LR) and recurrence index for distant recurrence (RI-DR).

Construction and Transition Metal Oxide Loading of Hierarchically Porous Carbon Aerogels.

Hierarchically porous carbon aerogels (CAs) were prepared by organic condensation gelation method combined with atmospheric drying and pore-formation technology, followed by a carbonization process. With as-prepared CAs as substrate, the transition metal oxide nanoparticles loaded CAs composites (MnO/MnO@CA and Ni/NiO@CA) were achieved by means of liquid etching method combined with heat treatment, respectively. The catalyst, pore-forming agent and etching have important roles on the apparent density and pore structure of CAs.

Ionic liquids facilitated dispersion of chitin nanowhiskers for reinforced epoxy composites.

In this work, we propose a novel approach to produce a high-strength epoxy nanocomposite using ionic liquids facilitated dispersion of chitin nanowhiskers (CNWs). Samples with 0-3 wt% CNWs and 1 wt% of [Emim][OAc] were fabricated by mixing, casting, and curing. The morphological observations of the ethanol/ionic liquid suspensions by TEM indicated that [Emim][OAc] helped in dispersing the CNWs.

Flexible, Reconfigurable, and Self-Healing TPU/Vitrimer Polymer Blend with Copolymerization Triggered by Bond Exchange Reaction.

In recent decades, flexible, reconfigurable, and fast-response self-healing polymers have attracted considerable attention for both industrial field and scientific research. Mechanical blending remains the most mature, economical, effective, and the simplest approach to produce polymer blends, which can combine several distinctive advantages from different thermoplastic materials. However, such a process cannot be simply applied to thermosetting materials due to their permanent molecular structures.

Reduced miR-203 predicts metastasis and poor survival in esophageal carcinoma.

We analyzed data from two non-coding RNA profiling arrays made available by the Gene Expression Omnibus (GEO) and found 17 miRNAs with remarkable differential expression between malignant and normal esophageal tissue. Correlation analysis between expression of these 17 miRNAs and patients' clinicopathological characteristics showed that miR-203 was down-regulated in esophageal carcinoma (EC) tissues and was significantly associated with lymph node metastasis and poor overall survival. Overexpression of miR-203 significantly attenuated cellular proliferation, migration and invasion by EC cells in culture.

DNA Methylation of miR-122 Aggravates Oxidative Stress in Colitis Targeting SELENBP1 Partially by p65NF-B Signaling.

Aberrant microRNA (miRNA) expressions contribute to the development and progression of various diseases, including Crohn's disease (CD). However, the accurate mechanisms of miRNAs in CD are definitely unclear. We employed colonic tissue samples from normal volunteers and CD patients, an acute mice colitis model induced by 2,4,6-trinitro-benzene-sulfonic acid (TNBS), and a cellular oxidative stress model induced by HO in HT-29 cells to determine the effects of oxidative stress on expressions of miR-122, selenium-binding protein 1 (SELENBP1, SBP1), p65 nuclear factor B (p65NF-B) signaling, and DNA methylation.

Octreotide-Conjugated Core-Cross-Linked Micelles with pH/Redox Responsivity Loaded with Etoposide for Neuroendocrine Neoplasms Therapy and Bioimaging with Photoquenching Resistance.

The study of multifunctional polymer micelles combined with chemotherapy due to reduced systemic toxicity and enhanced efficacy has attracted intensive attention. Herein, a multifunctional core-cross-linked hybrid micelle system based on mPEG- b-PGu(BA-TPE) and OCT-PEG- b-PGu(DA-TPE) with pH- and redox-triggered drug release and aggregation-induced emission (AIE) active imaging has been developed for active targeting of neuroendocrine neoplasms (NENs), especially neuroendocrine carcinomas (NECs) with poor prognosis. These micelles showed excellent biocompatibility and stability.

Chitin nano-whiskers (CNWs) as a bio-based bio-degradable reinforcement for epoxy: evaluation of the impact of CNWs on the morphological, fracture, mechanical, dynamic mechanical, and thermal characteristics of DGEBA epoxy resin.

Chitin nano-whiskers (CNWs) are high performance nanomaterials that can be extracted from chitin, which is one of the most widely available bio-resources. Herein we investigate the effect of CNWs on the morphological, mechanical, dynamic mechanical and thermal properties of DGEBA epoxy. Optically transparent, bulk epoxy nano-composites with 0.

Balanced design for the feasible super rocket fuels: A first-principle study on gauche CHN and CHN.

On the basis of the framework of cubic gauche nitrogen (cg-N), six one-eighth methanetriyl groups (>CH-) substitutes and fifteen one-fourth >CH- substitutes were optimized using the first-principle calculations based on density functional theory (DFT). Both one-eighth and one-fourth substitutes still keep the gauche structures with the simple formula CHN and CHN, respectively. The most thermodynamic stable gauche CHN and CHN are P2 qtg-CHN I and P2 qtg-CHN III, respectively.