A hollow fiber supported ionic liquid membrane contactor for continuous extraction of lithium from high magnesium/lithium ratio brine.

High-efficiency lithium (Li) extraction from a salt-lake brine with a low Li concentration and a high Mg/Li mass ratio poses a great challenge owing to the great physical and chemical similarities between Mg and Li. In this study, a hollow fiber (HF) membrane with an inside diameter of 0.872 mm and an outside diameter of 1.

Hepcidin mediates the disorder of iron homeostasis and mitochondrial function in mice under hypobaric hypoxia exposure.

The human body to prolonged high-altitude environments exposure can cause the decreased hepcidin and the disorder of iron homeostasis. Few animal studies have examined the molecular basis of iron metabolism disorder and the impact of hepcidin on the complex phenotype of high-altitude environments. In this study, we display reduced hepcidin level and impaired iron homeostasis upon hypobaric hypoxia, accompanied by mitochondrial dysfunction, abnormal blood cells and metabolic disorder.

Polylactic acid amine-sensitive colorimetric indicator film loaded with eugenol/coumarin derivatives: Towards freshness indication and shelf-life extension of chilled pork.

The action of microorganisms can lead to a decrease in food freshness and cause food safety issues. Traditional packaging can only provide a certain antimicrobial effect and cannot indicate the freshness of food, which can no longer meet the needs of consumers. The preparation of intelligent packaging films with antimicrobial effects and freshness indication is an effective solution.

Natural polysaccharides-based smart sensors for health monitoring, diagnosis and rehabilitation: A review.

With the rapid growth of multi-level health needs, precise and real-time health sensing systems have become increasingly pivotal in personal health management and disease prevention. Natural polysaccharides demonstrate immense potential in healthcare sensors by leveraging their superior biocompatibility, biodegradability, environmental sustainability, as well as diverse structural designs and surface functionalities. This review begins by introducing a variety of natural polysaccharides, including cellulose, alginates, chitosan, hyaluronic acid, and starch, and analyzing their structural and functional distinctions, which offer extensive possibilities for sensor design and construction.

Integrated degradation of bacteria, organic pollutants, total phosphorus, and antibiotics in food wastewater through immobilization of Bacillus velezensis on polyethylene glycol-polyvinyl alcohol/sodium alginate/nano-TiO microspheres.

Food wastewater is characterized by complex composition and a wide range of pollutants. Existing treatment methods are often inefficient for single pollutants and new, environmentally friendly, and integrated treatment methods are needed. This study aimed to construct a novel polyethylene glycol (PEG)-polyvinyl alcohol (PVA)/sodium alginate (SA)/nano-TiO hydrogel microsphere-immobilized Bacillus velezensis system for the integrated degradation of complex pollutant components in food wastewater.

SLC13A5 plays an essential role in the energy shift to oxidative phosphorylation in cisplatin-resistant mesothelioma stem cells.

Mesothelioma is a highly aggressive tumor affecting an increasing number of patients worldwide. Owing to the poor clinical outcomes associated with current therapies, the development of novel therapies that target cancer stem cells (CSCs) is desirable. Here, we examined the applicability of our previously established hydrogel-based rapid CSC generation method to human mesothelioma cell lines and further analyzed the characteristics of the induced mesothelioma stem cell (MesoSC) -like cells.

Enhancement of Oryzanol application by constructing modified β-CD inclusion complex and polycaprolactone-chitosan electrospun fiber membranes: Perspectives on wound dressings and grape preservation.

Oryzanol has a variety of physiological activities and is widely used in food and medicine. However, its utilization form and bioavailability are limited by poor solubility and photothermal stability. In this paper, an inclusion complex (IC) was prepared by modifying β-cyclodextrin as a molecular carrier to encapsulate Oryzanol.

Enhanced bioaccumulation and toxicity of Fenpropathrin by polystyrene nano(micro)plastics in the model insect, silkworm (Bombyx mori).

Background: Nano(micro)plastics (NMPs) and agrochemicals are ubiquitous pollutants. The small size and physicochemical properties of NMPs make them potential carriers for pollutants, affecting their bioavailability and impact on living organisms. However, little is known about their interactions in terrestrial ecosystems.

Global phylogeography and genetic characterization of carbapenem and ceftazidime-avibactam resistant KPC-33-producing Pseudomonas aeruginosa.

Ceftazidime-avibactam (CZA) is currently one of the last resorts used to treat infections caused by carbapenem-resistant Enterobacteriaceae and Pseudomonas aeruginosa. However, KPC variants have become the main mechanism mediating CZA resistance in KPC-producing gram-negative bacteria after increasing the application of CZA. Our previous study revealed that CZA-resistant KPC-33 had emerged in carbapenem-resistant P.

Sustainable application of waste gangue mortar in coal mine tunnel support.

With the increase in coal mining depths, soft and fractured roadway surrounding rocks require grouting and a sprayed protective layer for maintenance. Simultaneously, extensive accumulation of coal gangue causes diverse environmental issues. To enhance on-site coal gangue utilization, this study replaced river sand and cement with coal gangue to develop a novel cement-based mortar for supporting coal mine roadways.

An intelligent thymol/alizarin-loaded polycaprolactone/gelatin/zein nanofibrous film with pH-responsive and antibacterial properties for shrimp freshness monitoring and preservation.

Improper storage methods cause food resources to be wasted, and the development of multifunctional intelligent packaging can realize freshness monitoring and extend the shelf life. In this study, an intelligent alizarin/thymol-loaded polycaprolactone/gelatin/zein nanofibrous film was prepared and achieved the dual functions of pH-responsive and antibacterial properties. The film was fabricated using electrospun technology and characterized by SEM, FT-IR, WCA, TGA, DSC, and mechanical property tests, which had good antioxidant properties (81.

Phenotypic and genotypic characterization of clinical carbapenem-resistant species harboring the metallo-beta-lactamases IMP-8 or NDM-1 in China.

Unlabelled: Carbapenem-resistant spp. pose a significant challenge in clinical settings due to limited treatment options for nosocomial infections. Carbapenem-hydrolyzing class D beta-lactamases are the primary cause for carbapenem resistance, while metallo-beta-lactamases (MBLs) New Delhi metallo beta-lactamase (NDM) and imipenemase (IMP) also contribute.

Multifunctional Conjugated Polyphenol "Bridge" Capped the Upper Interface of Highly Efficient and Stable Inorganic Perovskite Solar Cells Fabricated in Air.

Carbon-based all-inorganic perovskite solar cells (C-PSCs) are promising alternatives compared with conventional organic-inorganic halide PSCs because of their good thermal stability. However, low carrier transport efficiency and energy level mismatch of the upper interface of the device limit the further improvement of power conversion efficiency (PCE), and all-inorganic perovskites are extremely sensitive to oxygen and humidity, which seriously damages the long-term stability of the device. Upper interface modification is an effective solution to improve the PCE and the stability of devices.

Clinical characteristics and prognosis of bloodstream infections with carbapenem-resistant Gram-negative organisms in patients with hematological malignancies: A multicenter case-control study in China.

Objective: To investigate clinical characteristics of hematological malignancy (HM) patients with carbapenem-resistant gram-negative organism (CRO) bloodstream infections (BSI) in China, and to elucidate the prognostic risk factors of CRO BSI.

Methods: We conducted a multicenter case-control study of 201 HM patients with CRO BSI between 2018-2020. Antimicrobial susceptibility testing and whole genome sequencing were performed for CRO isolates.

RXRα/MR signaling promotes diabetic kidney disease by facilitating renal tubular epithelial cells senescence and metabolic reprogramming.

Cell senescence and metabolic reprogramming are significant features of diabetic kidney disease (DKD). However, the underlying mechanisms between cell senescence and metabolic reprogramming are poorly defined. Here, we report that retinoid X receptor α (RXRα), a key nuclear receptor transcription factor, regulates cell senescence and metabolic reprogramming in DKD.

Evolution of ceftazidime-avibactam resistance driven by mutations in double-copy to during treatment of ST11 carbapenem-resistant .

Unlabelled: carbapenemase (KPC) variants can contribute to resistance to ceftazidime-avibactam (CZA) in (KP). However, two-copy KPC variant-mediated resistance to CZA has rarely been reported to date. Here, we aimed to clarify the evolutionary trajectory of CZA resistance driven by mutations in double-copy to carried by the tandem core structure (IS-IS-IS) during treatment of ST11 carbapenem-resistant (CRKP).

Hydrogel-based therapeutic strategies for spinal cord injury repair: Recent advances and future prospects.

Spinal cord injury (SCI) is a debilitating condition that can result in significant functional impairment and loss of quality of life. There is a growing interest in developing new therapies for SCI, and hydrogel-based multimodal therapeutic strategies have emerged as a promising approach. They offer several advantages for SCI repair, including biocompatibility, tunable mechanical properties, low immunogenicity, and the ability to deliver therapeutic agents.

Curcumin improves atrial fibrillation susceptibility by regulating tsRNA expression in aging mouse atrium.

Age is an independent risk factor for atrial fibrillation (AF), and curcumin can delay aging related disease through reducing oxidative stress and inflammation. However, its target in aging-related AF remains unclear. Transfer RNA-derived small RNA (tsRNA) is a novel short non-coding RNA (sncRNA), and exerts a potential regulatory function in aging.

A Local Search Algorithm with Vertex Weighting Strategy and Two-Level Configuration Checking for the Minimum Connected Dominating Set Problem.

The minimum connected dominating set problem is a combinatorial optimization problem with a wide range of applications in many fields. We propose an efficient local search algorithm to solve this problem. In this work, first, we adopt a new initial solution construction method based on three simplification rules.

Clinical and laboratory insights into the threat of hypervirulent Klebsiella pneumoniae.

Hypervirulent Klebsiella pneumoniae (hvKP) typically causes severe invasive infections affecting multiple sites in healthy individuals. In the past, hvKP was characterized by a hypermucoviscosity phenotype, susceptibility to antimicrobial agents, and its tendency to cause invasive infections in healthy individuals within the community. However, there has been an alarming increase in reports of multidrug-resistant hvKP, particularly carbapenem-resistant strains, causing nosocomial infections in critically ill or immunocompromised patients.

A panel of genotypically and phenotypically diverse clinical strains for novel antibiotic development.

Unlabelled: is one of the most important pathogens worldwide. The intrinsic and acquired resistance of , coupled with the slow pace of novel antimicrobial drug development, poses an unprecedented and enormous challenge to clinical anti-infective therapy of . Recent studies in the field of pathogenicity, antibiotic resistance, and biofilms of have focused on the model strains, including ATCC 17978, ATCC 19606, and AB5075.

Fitness effects of synthetic and natural diet preservatives on the edible insect Bombyx mori.

Silkworm pupae as widely consumed insect products are good biosources of protein and micronutrients. Silkworm rearing throughout the year can be achieved by feeding them an artificial diet instead of native plants, facilitating extensive pupa production. However, artificial diets are prone to spoilage caused by bacterial contamination.