Publications by authors named "Jinsub Han"

Article Synopsis
  • Developing a "scaffold-on-a-chip" device to improve the evaluation of bone regeneration has been a challenge in the field of tissue engineering.
  • This device simulates the microenvironment around a transplanted bone scaffold and includes a central space for scaffold placement and microfluidic channels for monitoring cellular interactions.
  • Testing with MC3T3-E1 cells showed that the device can effectively assess different scaffolds' properties, potentially replacing animal models and advancing bone regeneration studies.
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The use of bone graft materials is required for the treatment of bone defects damaged beyond the critical defect; therefore, injectable calcium phosphate cement (CPC) is actively used after surgery. The application of various polymers to improve injectability, mechanical strength, and biological function of injection-type CPC is encouraged. We previously developed a chitosan-PEG conjugate (CS/PEG) by a sulfur (VI) fluoride exchange reaction, and the resulting chitosan derivative showed high solubility at a neutral pH.

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Supramolecular hydrogels are considered promising drug carriers in the tissue engineering field due to their versatile nature. Chitosan hydrogels without chemical cross-linkers have low cytotoxicity and good delivery capacity; however, they have lower mechanical properties for injectable hydrogel usage. In this study, we developed novel chitosan derivatives via click chemistry for fabricating supramolecular hydrogels with higher mechanical strength under mild conditions.

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The 3D-printed bioactive ceramic incorporated Poly(ε-caprolactone) (PCL) scaffolds show great promise as synthetic bone graft substitutes. However, 3D-printed scaffolds still lack adequate surface properties for cells to be attached to them. In this study, we modified the surface characteristics of 3D-printed poly(ε-caprolactone)/hydroxyapatite scaffolds using O2 plasma and sodium hydroxide.

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