Development and validation of a radiomics-based nomogram for predicting pathological grade of upper urinary tract urothelial carcinoma.

Background: Upper urinary tract urothelial carcinoma (UTUC) is a rare and highly aggressive malignancy characterized by poor prognosis, making the accurate identification of high-grade (HG) UTUC essential for subsequent treatment strategies. This study aims to develop and validate a nomogram model using computed tomography urography (CTU) images to predict HG UTUC.

Methods: A retrospective cohort study was conducted to include patients with UTUC who underwent radical nephroureterectomy and received a CTU examination prior to surgery.

177Lu Radiolabeled Polydopamine Decorated with Fibroblast Activation Protein Inhibitor for Locoregional Treatment of Glioma.

Radionuclide therapy is expected to be a powerful tool for glioma treatment. Here, we introduce a novel nuclear nanomedicine based on polydopamine (PDA), incorporating fibroblast activation protein inhibitor (FAPI) and macrocyclic chelator (DOTA) for specific cancer targeting and 177Lu labeling. The synthesized nanoradiopharmaceutical, 177Lu-DOTA-PEG-PDA-FAPI, exhibits good stability in serum, saline and PBS over 5 days.

Epidemiological investigation of adult emergency infusion adverse drug reactions (EIADR) in Nanjing, China: a prospective cross-sectional study (EIADR II).

Objective: To analyze the clinical characteristics of adverse drug reactions (ADRs) in adults receiving emergency infusions at a tertiary hospital.

Methods: We conducted a prospective observational cohort study involving 585 adult patients who experienced adverse drug reactions (ADRs) between 20 November 2019, and 20 November 2023, during intravenous infusions in the emergency infusion room of a tertiary hospital. The analysis included patients' gender, age, type of drugs involved, organ-system involvement, clinical manifestations of ADRs, severity grading of ADRs, and preventability of ADRs.

Promising Pharmacological Interventions for Posterior Capsule Opacification: A Review.

Phacoemulsification combined with intraocular lens implantation is the primary treatment for cataract. Although this treatment strategy benefits patients with cataracts, posterior capsule opacification (PCO) remains a common complication that impairs vision and affects treatment outcomes. The pathogenesis of PCO is associated with the proliferation, migration, and fibrogenesis activity of residual lens epithelial cells, with epithelial-mesenchymal transition (EMT) serving as a key mechanism underlying the condition.

Coordinated behavior of autonomous microscopic machines through local electronic pulse coupling.

Increasingly functional microscopic machines are poised to have massive technical influence in areas including targeted drug delivery, precise surgical interventions, and environmental remediation. Such functionalities would increase markedly if collections of these microscopic machines were able to coordinate their function to achieve cooperative emergent behaviors. Implementing such coordination, however, requires a scalable strategy for synchronization-a key stumbling block for achieving collective behaviors of multiple autonomous microscopic units.

Corn Stover-derived nanocellulose and lignin-modified particles: Pickering emulsion stabilizers and potential quercetin sustained-release carriers.

Pickering emulsions (PEs) have wide applications in delivering nutraceuticals. However, the impact of extracting nanocellulose from corn stover on stabilizing PEs and delivering nutraceuticals remains unclear. In this study, four types of nanocellulose, cellulose nanocrystals (CNC), cellulose nanofibers (CNF), lignin-containing cellulose nanocrystals (LCNC), and lignin-containing cellulose nanofibers (LCNF) were successfully prepared from corn stover, an agricultural waste.

Effectiveness of Tai Chi exercise on balance, falls, and motor function in older adults: a meta-analysis.

Objective: This study systematically evaluated Tai Chi's effects on balance, fall prevention, and physical function in older adults.

Methods: A comprehensive literature search of PubMed, Web of Science, and EMbase databases included randomized controlled trials published up to August 2024. The meta-analysis used RevMan 5.

Identification and prediction of the degree of multidimensional returning to poverty risk for the household in China through the novel hybrid model: Based on the survey data of China Family Panel Studies (CFPS).

In China, absolute poverty has been effectively eliminated, but this does not signify the complete eradication of poverty. Instead, poverty persists in the forms of relative and secondary poverty. More concerningly, regions or households lifted out of poverty continue to face numerous risks of returning to poverty.

Empirical analysis of the influence mechanism of vegetation and environment on negative air ion in warm temperate forest ecosystems.

Air pollution presents a significant threat to public health in megacities globally. Negative air ions (NAI), often referred to as "air vitamins," are recognized for their effectiveness in alleviating the harmful effects of air pollution. Forest ecosystems serve as natural generators of NAI, with both vegetation and environmental conditions playing critical roles in the formation and persistence of NAI.

L-Theanine Effectively Protects Against Copper-Facilitated Dopamine Oxidation: Implication for Relieving Dopamine Overflow-Associated Neurotoxicities.

Non-physiological disorders release dopamine into extracellular brain fluid to induce neurodegenerative brain diseases. The harmful mechanism of dopamine overflow is attributed to the dopamine-mediated production of hydroxyl radicals, suggesting that transition metal copper which is high in the brain is involved in promoting dopamine oxidation. MPP+ , an intermediate formed from the conversion of MPTP, is one of the most potent dopamine-releasing agents.

Does the guide sheath outperform the non-guide sheath method in endobronchial ultrasound-guided biopsy of peripheral pulmonary lesions?-a meta-analysis.

Background: Endobronchial ultrasound (EBUS)-guided transbronchial biopsy with or without a guide sheath (EBUS-GS or EBUS-nGS) is commonly utilized for the diagnosis of peripheral pulmonary lesions (PPLs). The primary objective of this meta-analysis is to assess the diagnostic yield, surgical time, and safety of EBUS-GS and EBUS-nGS in patients presenting with PPLs, providing valuable insights for clinical decision-making.

Methods: We conducted a systematic search of four databases (PubMed, Embase, Web of Science, Cochrane Library) up to January 2024.

Overcoming EGFR-TKI resistance by targeting the tumor microenvironment.

Targeted therapy has ushered in a new era of precision medicine for non-small cell lung cancer (NSCLC). Currently, epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) stand as the recommended first-line therapy for advanced NSCLC harboring sensitive mutations. Nevertheless, most patients inevitably confront the challenge of drug resistance.

CARTp/GPR160 mediates behavioral hypersensitivities in mice through NOD2.

Neuropathic pain is a debilitating chronic condition that remains difficult to treat. More efficacious and safer therapeutics are needed. A potential target for therapeutic intervention recently identified by our group is the G-protein coupled receptor 160 (GPR160) and the cocaine- and amphetamine-regulated transcript peptide (CARTp) as a ligand for GPR160.

The Effects of Mixed and Plantation on Soil Bacterial Community Structure and Nitrogen-Cycling Gene Abundance in the Southern Taihang Mountain Foothills.

Mixed forests often increase their stability and species richness in comparison to pure stands. However, a comprehensive understanding of the effects of mixed forests on soil properties, bacterial community diversity, and soil nitrogen cycling remains elusive. This study investigated soil samples from pure stands, pure stands, and mixed stands of both species in the southern foothills of the Taihang Mountains.

[Oscillation-static cycle cultivation enhances the synthesis of triterpenes and mycelium activity in ].

is a precious fungus with both edible and medicinal values and has a long history of medical use. Triterpenes as the main active components endow . with anti-tumor, antioxidant, and other pharmacological activities.

A stable thymidine kinase 1 tetramer for improved quality control of serum level quantification.

DNA synthesis is a critical process for cell growth and division. In cancer patients, an enzyme called thymidine kinase 1 (TK1) is often elevated in the blood, making it a valuable biomarker for cancer diagnosis and treatment. However, previous studies have shown that recombinant TK1 can exist in unstable mixtures of tetramers and dimers, leading to inconsistent results and potentially affecting accuracy.

Enhanced nitrogen removal for low C/N wastewater via preventing futile carbon oxidation and augmenting anammox.

Efficient carbon use is crucial for biological nitrogen removal. Traditional aerobic processes can waste carbon sources, exacerbating carbon deficiency. This study explores an anaerobic/oxic/anoxic system with sludge double recirculation to improve nitrogen removal in low C/N wastewater.

Parametrization of lower limit temperature in crop water stress index model: A case study of plantation.

The lower limit temperature in the crop water stress index (CWSI) model refers to the canopy temperature () or the canopy-air temperature differences () under well-watered conditions, which has significant impacts on the accuracy of the model in quantifying plant water status. At present, the direct estimation of lower limit temperature based on data-driven method has been successfully used in crops, but its applicability has not been tes-ted in forest ecosystems. We collected continuously and synchronously and meteorological data in a plantation at the southern foot of Taihang Mountain to evaluate the feasibility of multiple linear regression model and BP neural network model for estimating the lower limit temperature and the accuracy of the CWSI indicating water status of the plantation.

Electronically actuated artificial hinged cilia for efficient bidirectional pumping.

Cilial pumping is a potent mechanism used to control and manipulate fluids on microscales. Recently, we introduced an electronically driven μ-cilial platform that can create arbitrary flow patterns in liquids near a surface with the potential for various engineering applications. This μ-cilial platform, however, utilized the coupling between elasticity and viscous drag to obtain pumping and had several limitations.

Deep-learning-assisted sidewall profiling white light interferometry system for accurately measuring 3D profiles and surface roughness on the groove sidewalls of precision components.

The accurate measurement of surface three-dimensional (3D) profile and roughness on the groove sidewalls of components is of great significance to diverse fields such as precision manufacturing, machining processes, energy transportation, medical equipment, and semiconductor industry. However, conventional optical measurement methods struggle to measure surface profiles on the sidewall of a small groove. Here, we present a deep-learning-assisted sidewall profiling white light interferometry system, which consists of a microprism-based interferometer, an optical path compensation device, and a convolutional neural network (CNN), for the accurate measurement of surface 3D profile and roughness on the sidewall of a small groove.

Membrane protein MHZ3 regulates the on-off switch of ethylene signaling in rice.

Ethylene regulates plant growth, development, and stress adaptation. However, the early signaling events following ethylene perception, particularly in the regulation of ethylene receptor/CTRs (CONSTITUTIVE TRIPLE RESPONSE) complex, remains less understood. Here, utilizing the rapid phospho-shift of rice OsCTR2 in response to ethylene as a sensitive readout for signal activation, we revealed that MHZ3, previously identified as a stabilizer of ETHYLENE INSENSITIVE 2 (OsEIN2), is crucial for maintaining OsCTR2 phosphorylation.