Publications by authors named "Jinsol Choi"
Parkinson's disease is a neurodegenerative disorder characterized by cardinal motor symptoms resulting from the loss of dopaminergic neurons in the substantia nigra pars compacta. Although current medications may alleviate its symptoms, Parkinson's disease remains incurable. Astaxanthin is an antioxidant and anti-inflammatory agent; however, its high susceptibility to oxidative degradation and low aqueous solubility limit its therapeutic efficacy.
View Article and Find Full Text PDFDeveloping a portable yet affordable method for the discrimination of chemical substances with good sensitivity and selectivity is essential for on-site visual detection of unknown substances. Herein, we propose an optofluidic paper-based analytical device (PAD) that consists of a macromolecule-driven flow (MDF) gate and photonic crystal (PhC) coding units, enabling portable and scalable detection and discrimination of various organic chemical, mimicking the olfactory system. The MDF gate is designed for precise flow control of liquid analytes, which depends on intermolecular interactions between the polymer at the MDF gate and the liquid analytes.
View Article and Find Full Text PDFArticle Synopsis
- Extracellular vesicles (EVs) from Lactobacillus reuteri (L. reuteri), a probiotic, show potential as an effective cancer treatment when taken orally, demonstrating stability in the digestive tract.
- In lab studies using A549 cancer cells and mice, L. reuteri-derived EVs (REVs) were found to activate apoptosis and enhance the effectiveness of other cancer drugs.
- In a mouse model, REVs combined with photothermal therapy completely eliminated tumors in 32 days, highlighting their promise as a standalone or adjunct treatment for cancer.
Cancer cells mechanically interact with the tumor microenvironment during cancer development. Mechano-reciprocity has emerged as a crucial factor affecting anti-cancer drug resistance during adjuvant therapy. Here, we investigated the focal adhesion kinase (FAK)/Yes-associated protein (YAP) signaling axis as a prospective strategy for circumventing cisplatin resistance in ovarian cancer (OC).
View Article and Find Full Text PDFMicrofluidic paper-based analytical devices (μPADs) have been developed for use in a variety of diagnosis and analysis fields. However, conventional μPADs with an open-channel system have limitations for application as analytical platforms mainly because of the evaporation and contamination of the sample solution. This study demonstrates the design and fabrication of an enclosed three-dimensional(3D)-μPAD and its application as a primary early analysis platform for ionic contaminants.
View Article and Find Full Text PDFArticle Synopsis
- Research on the mechanical properties of drug-resistant breast cancer cells was conducted using atomic force microscopy and nanostructured surfaces to identify their unique mechanical signatures.
- The study revealed that drug-resistant cells had stronger mechanical characteristics, more actin stress fibers, and increased activity of focal adhesion proteins like vinculin and FAK.
- Co-treatment with a FAK inhibitor proved to be more effective at eliminating drug-resistant cells than conventional methods, suggesting a promising new strategy for overcoming drug resistance in breast cancer.