Publications by authors named "Jinshui Pan"
Background & Aims: Approved drugs for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) are limited, although it has become the most common chronic liver disease worldwide. 1-phenyl-3-methyl-5-pyrazolone (PMP) possesses various biological effects such as anti-inflammatory and antioxidant. However, the effects and underlying mechanism of PMP in MASH remain unclear.
View Article and Find Full Text PDFBackground: Currently, there is a lack of global or even country/regional level data on adolescent non-alcoholic fatty liver disease (NAFLD) prevalence. However, an evidenced dose-dependent relationship exists between body mass index (BMI) and the risk of NAFLD. We aim to estimate the global and regional prevalence of adolescent NAFLD and related non-alcoholic steatohepatitis (NASH) based on BMI.
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- The analysis aimed to offer insights for addressing multi drug resistant tuberculosis (MDR-TB) by examining its burden, trends, risks, and future projections.
- Researchers utilized the Global Burden of Disease (GBD) 2019 dataset to evaluate key metrics like disability-adjusted life years (DALYs) and mortality, employing various statistical methods to analyze trends and project future incidence.
- Findings revealed that MDR-TB poses a significant health challenge in low socio-demographic regions, particularly affecting older men, with alcohol consumption identified as a major risk factor; urgent strategies are necessary to combat TB by 2030 in these areas.
Introduction And Objectives: This meta-analysis aims to evaluate the efficacy of stem cell therapy (SCT) for liver failure.
Materials And Methods: The study adhered to the recommended guidelines of the PRISMA statement. Eligible studies published prior to May 13, 2023, were comprehensively searched in databases including PubMed, Web of Science, and Embase.
Background: At present, there is a dearth of comprehensive data at the global, national, and regional levels regarding the adult non-alcoholic fatty liver disease (NAFLD) prevalence. This cross-sectional study aims at ascertaining the prevalence of NAFLD and non-alcoholic steatohepatitis (NASH), utilizing body mass index (BMI) as a determining factor.
Methods: Based on the NHANES database, sigmoidal fitting curves were generated to establish the relationship between BMI and the risk of NAFLD/NASH.
Objectives: To provide valuable insights for targeted cancer screening among high-risk patients, we analyzed the global and regional burden of neoplasms resulting from alcohol consumption between 1990 and 2019.
Methods: The information used in this study was collected from the Global Burden of Disease 2019 dataset. Initially, the database was used to extract details of mortality rates, disability-adjusted life years (DALYs), and the number of individuals affected by alcohol-related neoplasms (ARNs).
Article Synopsis
- The study investigates the potential causal relationship between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD), particularly focusing on ulcerative colitis (UC) and Crohn's disease (CD).
- It uses Mendelian Randomization and genetic variants to analyze the effects of genetically predicted PSC on the risk of developing IBD, identifying a significant link to UC but not to CD.
- The findings highlight a causal association between genetically predicted PSC and UC, while calling for more research to explore shared genetic factors and underlying mechanisms connecting PSC and IBD.
Article Synopsis
- The study investigates the link between dental scaling (DS) and the risk of spontaneous intracranial hemorrhage (ICH), finding that regular DS might lower the incidence of ICH compared to those who do not undergo DS.
- In a cohort of over 681,000 subjects, those who received regular DS had a significantly lower ICH incidence (0.8%) compared to non-DS individuals (1.2%), with an adjusted hazard ratio of 0.61 for ICH risk.
- The results suggest that individuals aged 30-39 who regularly underwent DS experienced the lowest ICH risk, indicating that DS may play a role in reducing hypertension and ICH-related health issues.
Article Synopsis
- - Traditional Chinese Medicine (TCM) is being investigated for its potential to help with liver issues related to chronic hepatitis B, but its effectiveness on HBsAg seroclearance is still not well understood.
- - In a study, mice were treated with specific TCM granules to see their impact on M1 macrophage polarization and HBsAg levels, and a special TCM formula was developed based on the most effective granules.
- - The findings indicated that the TCM formula improved HBsAg seroclearance, likely by promoting M1 macrophage activity and altering gut microbiota, particularly increasing the presence of Alloprevotella.
Article Synopsis
- Non-alcoholic fatty liver disease (NAFLD) is linked to metabolic syndrome, which increases cancer risk, prompting the need for customized cancer screening in high-risk patients.
- The study analyzed data from the Global Burden of Disease 2019 to find that metabolic risks significantly contribute to certain cancers, with age-standardized rates showing higher impacts in older men and individuals with a higher socio-demographic index.
- Results suggest a strong connection between NAFLD and various cancers, advocating for focused cancer screenings for those affected by NAFLD, especially those at greater risk.
Background: Coronavirus disease (COVID-19) patients exhibit different patterns of liver impairment, according to growing evidence.
Aim: In this study, we sought to provide a comprehensive analysis of liver test parameters in patients with severe and non-severe COVID-19.
Methods: We performed a meta-analysis of published liver manifestations and described the liver damage in COVID-19.
Background: To understand the impact of common cancers of the gastrointestinal tract and help to formulate evidence-based policy, we evaluate the relationship between the burden of GI tract cancers and socioeconomics.
Methods: Data on GI tract cancer burden were obtained from the Global Burden of Disease (GBD) 2019 including mortality and incidence rates. According to the Socio-demographic Index (SDI) level, country and territory, and sex, , the data were further stratified.
Background: This study compared clinical features of the Delta variant of coronavirus disease 2019 (COVID-19) in children and adults.
Methods: Clinical data included 80 children and 132 adults with the Delta variant of COVID-19, hospitalized in the Affiliated Hospital of Putian College between September and October 2021. The data was analyzed retrospectively.
Socioeconomics and attributable etiology of primary liver cancer, 1990-2019.
World J Gastroenterol
June 2022
Background: Primary liver cancer (PLC) is a major contributor to cancer-related deaths. Data on global and country-specific levels and trends of PLC are essential for understanding the effects of this disease and helping policymakers to allocate resources.
Aim: To investigate the association between the burden of PLC and socioeconomic development status.
Background And Aims: We aim to develop a diagnostic tool for pathological-image classification using transfer learning that can be applied to diverse tumor types.
Methods: Microscopic images of liver tissue with and without hepatocellular carcinoma (HCC) were used to train and validate the classification framework based on a convolutional neural network. To evaluate the universal classification performance of the artificial intelligence (AI) framework, histological images from colorectal tissue and the breast were collected.
Patients with diabetes mellitus (DM) are at increased risk of developing several cancers; however, there is a lack of consensus on the relationship between gastric cancer (GC) and DM. This study aimed to explore the association between GC and DM based on the type and duration of DM. We searched nine databases from inception to December 1, 2021, and 40 cohort studies that evaluated the relationship between DM and the incidence of GC were included in this review.
View Article and Find Full Text PDFStandardized Nursing Procedures for Fecal Microbiota Transplantation via Upper Endoscopy.
Gastroenterol Nurs
November 2021
Fecal microbiota transplantation is an emerging treatment option that lacks a standardized nursing procedure. In our department, fecal microbiota transplantation has been undertaken to treat chronic hepatitis B and inflammatory bowel diseases since 2015. The fecal microbiota transplantation process involves various nursing measures that are critical for the successful completion of the procedures.
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- Acute viral hepatitis (AVH) is a significant global health issue, yet research focuses more on chronic infections like HBV and HCV; understanding the burden of AVH is essential for creating global intervention strategies.
- The study analyzed data from the Global Burden of Disease (GBD) 2019 on acute hepatitis A, B, C, and E, revealing high incidence rates in low socio-demographic index (SDI) regions, especially in West and East Africa.
- Findings indicate a correlation between lower socioeconomic status and higher AVH burden, suggesting that policymakers should leverage GBD 2019 data for effective interventions.
Tenofovir and entecavir are currently designated as the preferred oral antiviral drugs for chronic hepatitis B. However, only less than 40% of patients can achieve HBeAg seroconversion. We aim at investigating the role of intestinal microbiome in HBeAg seroconversion induced by oral antiviral therapy and describe multi-omics characteristics of HBeAg seroconversion associated intestinal flora.
View Article and Find Full Text PDFIntroduction: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Despite the therapeutic advances in HCC in the past few decades, the mortality rate of HCC is still high. Hepatitis C (HCV) infection is one of the major etiological risk factors of HCCs.
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- A meta-analysis of 19 studies involving 4,103 COVID-19 patients investigated the link between liver damage and clinical outcomes, revealing distinct liver chemistry patterns for those who died versus those discharged alive.
- Patients who died showed higher levels of alanine aminotransferase and aspartate aminotransferase, and displayed lower albumin levels, longer prothrombin times, and higher international normalized ratios compared to survivors.
- The study categorized liver impairment into three types: hepatocellular injury, cholestasis, and hepatocellular dysfunction, emphasizing the need for careful monitoring of liver function in COVID-19 patients.
Article Synopsis
- Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition, and the study investigates how zinc finger and BTB domain-containing 7A (ZBTB7A) contributes to its progression.
- Methods included various biological assays to measure ZBTB7A levels in both mouse models with high-fat diets and human liver cells exposed to oleic acid.
- Findings revealed that ZBTB7A is upregulated in NAFLD, correlating with inflammation and lipid accumulation, and its inhibition reduces lipid buildup while promoting fat oxidation.
Although a liver stiffness measurement-based model can precisely predict significant intrahepatic inflammation, transient elastography is not commonly available in a primary care center. Additionally, high body mass index and bilirubinemia have notable effects on the accuracy of transient elastography. The present study aimed to create a noninvasive scoring system for the prediction of intrahepatic inflammatory activity related to chronic hepatitis B, without the aid of transient elastography.
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