Modified Sistrunk Procedure in 391 Pediatric Thyroglossal Duct Cyst Cases: Clinical Analysis of Efficacy and Recurrence Risk.

The study aims to retrospectively summarize the clinical features of pediatric thyroglossal duct cyst (TGDC), investigate the efficacy of the modified Sistrunk (mSis) procedure, and analyze the recurrence risks. The clinical data of 391 children with TGDC admitted to Beijing Children's Hospital affiliated Capital Medical University and Baoding Children's Hospital from March 2012 to December 2021 were retrospectively analyzed. All patients underwent cervical ultrasound for preoperative evaluation.

[Surgical methods of cerebrospinal fluid otorhinorrhea due to inner ear malformation in children].

To discuss the application of two surgical methods, trans-mastoid approach and trans-canal endoscopic approach, in the treatment of CerebroSpinal Fluid（CSF） otorhinorrhea due to inner ear malformation（IEM） in children. Children with CSF otorhinorrhea due to IEM, from July 2015 to Jan 2021, in ENT department, Beijing Children's Hospital were retrospectively analyzed, and the clinical data, surgical methods, complications, recurrence and follow-up were recorded. 30 children with CSF otorhinorrhea due to IEM were included.

Clinical evaluation of cochlear implantation in children younger than 12 months of age.

Importance: Cochlear implantation (CI) is an effective therapy for patients with severe to profound sensorineural hearing loss. It remains controversial whether children younger than 12 months of age should undergo CI.

Objective: To evaluate the safety and effectiveness of CI in children younger than 12 months of age.

[The short-term and long-term efficacy of balloon dilatation Eustachian tuboplasty and tympanostomy tubes in children patients with recurrent otitis media with effusion].

To evaluate the short-term and long-term efficacy of balloon dilatation Eustachian tuboplasty（BET） and insertion of tympanostomy tubes in the treatment of recurrent otitis media with effusion（OME） in children, and to provide new ideas for the treatment of OME. We made a retrospective analysis of 29 OME patients who had accepted BET and insertion of tympanostomy tubes in Beijing Children's Hospital. Their case history, the past history of insertion of tympanostomy tubes or adenoidectomy, and the audiometry and Eustachian tube function before surgery and 1 month, 6 months, 9 months, 12 months, 18 months, 24 months and 36 months after surgery were recorded.

The Significance of Staging in the Treatment of Congenital Cholesteatoma in Children.

Objectives: To analyze the clinical characteristics of congenital cholesteatoma (CC), to explore the risk factors related to recurrence of the disease, and to clarify the importance of staging for treatment.

Methods: A total of 87 patients were followed up for more than 5 years, who had undergone surgical procedures for CC from September 2010 to January 2017 in Beijing Children's Hospital, Capital Medical University. Patients with CC were identified in accordance with the following Levenson's criteria.

Concurrent Hearing and Genetic Screening of 180,469 Neonates with Follow-up in Beijing, China.

Concurrent hearing and genetic screening of newborns is expected to play important roles not only in early detection and diagnosis of congenital deafness, which triggers intervention, but also in predicting late-onset and progressive hearing loss and identifying individuals who are at risk of drug-induced HL. Concurrent hearing and genetic screening in the whole newborn population in Beijing was launched in January 2012. This study included 180,469 infants born in Beijing between April 2013 and March 2014, with last follow-up on February 24, 2018.

Comparison of the development of early auditory and preverbal skills in Mandarin-Speaking children with cochlear implants with and without additional disabilities.

Few studies had assessed the auditory and preverbal skills of very young cochlear implant (CI) children with additional disabilities (AD) over a long period, especially in China. The aim of this study was to compare the early auditory and preverbal developmental trajectories in CI children with and without AD. The LittlEARS Auditory Questionnaire (LEAQ) was employed.

Correction to: Compare two surgical interventions for otitis media with effusion in young children.

In the original publication, Table 5 and 6 were interchanged by mistake. The correct tables are given here.

Compare two surgical interventions for otitis media with effusion in young children.

Objective: To prospectively evaluate the effect of tympanostomy tubes combined with adenoidectomy and tube insertion on treatment for otitis media with effusion in young children, and to analyze the related factors of prognosis and recurrence of the disease.

Methods: The clinical and follow-up data of 184 children with otitis media with effusion who were treated in the department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University from September 2013 to January 2015, were reviewed systematically. According to different surgical methods, they were randomly divided into the observation group in which patients were treated with tube insertion combined with adenoidectomy, and control group in which the rest underwent simple tube insertion.

Clinical analysis of first branchial cleft anomalies in children.

Importance: First branchial cleft anomaly (FBCA) is a rare disease that is difficult to diagnose and is associated with a high rate of complications. However, the difference between two types of FBCA and how to avoid complications are not clear enough.

Objective: We retrospectively analyzed type I and II (Work's classification) FBCAs in children to demonstrate the difference between the two types of FBCAs, especially with respect to understanding the relationship between FBCAs and the facial nerve.

Early auditory skills development in Mandarin speaking children after bilateral cochlear implantation.

Objectives: The purpose of the present study was: (1) to investigate the early auditory preverbal behaviors of infants/toddlers with bilateral cochlear implants (BCI), and to compare their performance with that of unilateral cochlear implant (UCI) peers; (2) to investigate effects of age of implantation, education level of caregivers, living environment, and unaided behavioral threshold before operation on early auditory preverbal development.

Methods: The evaluation material of the present study was the Mandarin version of the LittlEARS Auditory Questionnaire (LEAQ). Assessments were administrated at 0, 1, 2, 3, 6, 9, 12 and 24 months after cochlear implants (CIs) were switched on.

Health-Related Quality of Life in Mandarin-Speaking Children With Cochlear Implants.

Objectives: The primary aim of this study was to evaluate the health-related quality of life (HRQoL) of children with cochlear implants (CIs) from the parental perspective. The secondary objective was to explore possible relationships between demographic variables (such as age at assessment, gender, age at implantation, and duration of language rehabilitation) and the HRQoL. The third objective was to determine the developmental trajectories of HRQoL.

The treatment for the first branchial cleft anomalies in children.

The objective of this study is to make a clinical analysis for first branchial cleft anomalies (FBCAs), especially introduce the relationship between the Type I/II FBCA with the facial nerve and to demonstrate the importance of using intraoperative microscope and facial nerve monitoring. This is a retrospective review of patients with FBCAs treated in Beijing Children's Hospital, from Jan 2013 to Dec 2015. Clinical data of patients, including sex, age, chief complains, history of surgery, incision and drainage, the relationship with the facial nerve, pre and post-operative facial paralysis, recurrent rate and complications were recorded.

The value of Gesell score in predicting the outcome of cochlear implantation in children.

The purpose is to determine the value of preoperative evaluation on developmental levels using Gesell score in predicting the postoperative outcome in pediatric cochlear implantation (CI) recipients. 78 children who underwent CI were included in our study. Age at the time of CI ranged from 6 to 67 months.

Deafness gene mutations in newborns in Beijing.

Objective: To determine the incidence of congenital hearing loss (HL) in newborns by the rate of deafness-related genetic mutations.

Design: Clinical study of consecutive newborns in Beijing using allele-specific polymerase chain reaction-based universal array.

Study Sample: This study tested 37 573 newborns within 3 days after birth, including nine sites in four genes: GJB2 (35 del G, 176 del 16, 235 del C, 299 del AT), SLC26A4 (IVS7-2 A > G, 2168 A > G), MTRNR1 (1555 A > G, 1494 C > T), and GJB3 (538 C > T).

GJB2 mutation spectrum in 2,063 Chinese patients with nonsyndromic hearing impairment.

Background: Mutations in GJB2 are the most common molecular defects responsible for autosomal recessive nonsyndromic hearing impairment (NSHI). The mutation spectra of this gene vary among different ethnic groups.

Methods: In order to understand the spectrum and frequency of GJB2 mutations in the Chinese population, the coding region of the GJB2 gene from 2063 unrelated patients with NSHI was PCR amplified and sequenced.