Emodin ameliorates acute radiation proctitis in mice by regulating AKT/MAPK/NF-κB/VEGF pathways.

Background: Emodin, a natural anthraquinone derivative isolated from the roots of Rheum officinale Baill, has many pharmacological effects including anti-inflammatory, antioxidant, antiviral, antibacterial and anti-cancer. However, little is known about the effect of emodin on acute radiation proctitis (ARP). The present study was conducted to determine its effects and elucidate its mechanisms involving AKT/MAPK/NF-κB/VEGF pathways in ARP mice.

Applying molecular docking to pesticides.

Pesticide creation is related to the development of sustainable agricultural and ecological safety, and molecular docking technology can effectively help in pesticide innovation. This paper introduces the basic theory behind molecular docking, pesticide databases, and docking software. It also summarizes the application of molecular docking in the pesticide field, including the virtual screening of lead compounds, detection of pesticides and their metabolites in the environment, reverse screening of pesticide targets, and the study of resistance mechanisms.

Novel mechanisms underlying inhibition of inflammation-induced angiogenesis by dexamethasone and gentamicin via PI3K/AKT/NF-κB/VEGF pathways in acute radiation proctitis.

Acute radiation proctitis (ARP) is one of the most common complications of pelvic radiotherapy attributed to radiation exposure. The mechanisms of ARP are related to inflammation, angiogenesis, and so on. In this study we evaluated the effect of dexamethasone (DXM) combined with gentamicin (GM) enema on ARP mice, and explored its possible mechanisms by transcriptome sequencing, western blot and immunohistochemistry.

[Strategic Exploration of Targeted Therapy for BRAF Non-V600E Mutant Lung Cancer].

Background: Dabrafenib+Trametinib/Dabrafenib targeted therapy has been approved for V-RAF murine sarcoma viral oncogene homolog B1 with amino acid substitution for valine at position 600 (BRAF V600E) in lung cancer patients, however, the targeted therapy strategy for lung cancer patients with BRAF non-V600E mutations has not been determined yet. This study intends to explore the efficacy of targeted therapy for BRAF non-V600E mutant lung cancer, and provide a reference for clinical treatment.

Methods: Computer search of PubMed, Cochrane Library, Embase, Web of Science, Clinicaltrials.

Study on physicochemical characteristics, solidification and utilisation of tannery sludge gasification ash.

Gasification is an attractive method for tannery sludge (TS) disposal because of its advantages: volume reduction, stabilisation, harmlessness, and energy recovery. TS reduction ash (A) and TS oxidation ash (A), simulated from a downdraft fixed bed gasifier (DFBG) and an updraft fixed bed gasifier (UFBG), were investigated on their physicochemical characteristics, solidification behaviour, and value-added utilisation. Results showed that the main mineral matters in A and A consisted of Fe-oxids and Fe-Cr compounds, and the DFBG was more suitable for TS gasification than the UFBG because of the lower content of Cr(Ⅵ) in A.

Study of modeling and optimization for predicting the acute toxicity of carbamate pesticides using the binding information with carrier protein.

To predict drug acute toxicity using the binding information with human serum albumin, our research group established a new method (Carrier protein binding information-toxicity relationship, CPBITR). Unfortunately, the previous model had too few data sets which may affect the accuracy and credibility of the model. In this paper, therefore, we measured the binding modes of three carbamate pesticides, Bendiocarb, Butocarboxim and Dioxacarb with human serum albumin (HSA) to supplement the previously modeled training set.

Diagnostic value of indocyanine green for sentinel lymph node mapping and lymph node metastasis in oral/oropharyngeal carcinoma.

Indocyanine green (ICG) fluorescence-based sentinel lymph node (SLN) biopsy has been promoted to detect early metastasis of oral/oropharyngeal carcinoma, but its diagnostic value still remains unclear. In this letter, we identified 6 studies on ICG fluorescence based SLN in the detection of lymph node metastasis in oral/oropharyngeal carcinoma. For detection of metastatic lymph node, the overall sensitivity and specificity of the studies were 0.

A new method for predicting the acute toxicity of carbamate pesticides based on the perspective of binding information with carrier protein.

Toxicity is one of the most important factors limiting the success of new drug development. In this paper, we built a fast and convenient new method (Carrier protein binding information-toxicity relationship, CPBITR) for predicting drug acute toxicity based on the perspective of binding information with carrier protein. First, we studied the binding information between carbamate pesticides and human serum albumin (HSA) through various spectroscopic methods and molecular docking.

Characteristics of Online Health Care Services From China's Largest Online Medical Platform: Cross-sectional Survey Study.

Background: Internet hospitals in China are in great demand due to limited and unevenly distributed health care resources, lack of family doctors, increased burdens of chronic diseases, and rapid growth of the aged population. The COVID-19 epidemic catalyzed the expansion of online health care services. In recent years, internet hospitals have been rapidly developed.

Combination of curcumin and ginkgolide B inhibits cystogenesis by regulating multiple signaling pathways.

Autosomal dominant polycystic kidney disease (ADPKD), a common disease with a high incidence ratio of between 1/400 and 1/1,000 individuals, often results in kidney failure and even mortality. However, there are relatively few effective treatments available, and treatment is limited to lifelong hemodialysis or kidney transplant. Our previous studies have reported that curcumin (Cur) and ginkgolide B (GB) inhibited cystogenesis by regulating the Ras/ERK MAPK signaling pathway.

Beta amyloid-induced time-dependent learning and memory impairment: involvement of HPA axis dysfunction.

Aβ aggregation is one of the pathological biomarkers of Alzheimer's disease (AD). However, the possible mechanism related to Aβ-induced pathological signaling pathway is still unknown. In the present study, Aβ1-42-induced time-dependent memory impairment and its possible relationship to hypothalamic-pituitary-adrenal (HPA) axis hyperactivity were examined.

Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF-κB and VEGF.

Purpose: Changrui enema, a traditional Chinese medicine prescription, is used as a supplementary treatment for acute radiation proctitis (ARP). Herein we explored the inhibition effects of Changrui enema on NF-κB and VEGF in ARP mice.

Methods: A total of 120 C57BL/6 mice were divided randomly into normal mice group, ARP mice group, western medicine enema group (dexamethasone combined with gentamicin), and Changrui enema group.

Three pairs of luminescent coordination polymers based on Co and Cd clusters for the detection of antibiotics, pesticides and chiral nitro aromatic compounds.

Three couples of coordination polymers (CPs), namely, [Co((/)-Hcna)] (1-D/L), [Cd((1,2/1,2)-cpba)(phen)(HO)] (2-D/L) and [Cd((1,2/1,2)-Hcpba)(phen)] (3-D/L) {(/)-Hcna = (/)-6-(1-carboxyethoxy)-2-naphthoic acid, (1,2/1,2)-Hcpba = (1,2/1,2)-2,2'-((5-carboxy-1,3-phenylene)bis(oxy))dipropionic acid, phen = 1,10-phenanthroline} are successfully synthesized under hydrothermal conditions. Structural analysis shows that CP 1 has a 3D 3,6-c net structure with a point symbol of (4·6)(4·6·8). CPs 2 and 3 are obtained under very similar reaction conditions except using different solvent ratios.

Three new coordination polymers based on bis(4-(4-1,2,4-triazol-4-yl)phenyl)methane: syntheses, structures, multiresponsive luminescent sensitive detection for antibiotics and pesticides, and antitumor activities.

Three novel coordination polymers (CPs), namely, {[Ag(L)(MoO)·(CHCN)]} (1), {[Zn(L)(1,4-bdc)·2(1,4-Hbdc)]} (2), {[Cd(L)(1,4-bdc)]} (3) have been synthesized under solvothermal conditions by the reaction of bis(4-(4-1,2,4-triazol-4-yl)phenyl)methane (L) and varied metal salts. Their structures are determined by single X-ray crystal diffraction, and further characterized by elemental analysis, IR, TGA and PXRD. CP 1 with ammonium molybdate as a secondary ligand displays a 2D network with (2,3,3,3,4)-connected net topology and the point symbol of {4·8}{4·8·10}{8}, CP 2 and CP 3 with 1,4-Hbdc as a secondary ligand demonstrate 3D structures with different topologies.

Diosgenin exhibits tumor suppressive function via down-regulation of EZH2 in pancreatic cancer cells.

Pancreatic cancer (PC) is one of the most aggressive and lethal malignancies worldwide. Although significant progress has been made in oncology treatment, this refractory disease is still become intractable. Natural herb product diosgenin is described to exhibit vast range of pharmacological activities in preclinical studies, including anti-cancer activities.

Correction: Diagnostic role of 18F-FDG PET/MRI in patients with gynecological malignancies of the pelvis: A systematic review and meta-analysis.

[This corrects the article DOI: 10.1371/journal.pone.

Diagnostic role of 18F-FDG PET/MRI in patients with gynecological malignancies of the pelvis: A systematic review and meta-analysis.

Purpose: The aim of this study was to assess the diagnostic performance of 18F-FDG Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) for gynecological cancers of the pelvis, based on a systematic review and meta-analysis of published data.

Methods: We performed a comprehensive literature search of Pubmed and Embase for studies that evaluated the diagnosis of 18F-FDG PET/MRI for gynecological malignancies in the pelvis. Quality Assessment for Studies of Diagnostic Accuracy 2 (QUADAS 2) tool was used to access the quality of included studies.

Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid.

Neonatal hypoxic ischemic encephalopathy (HIE) is a common disease caused by perinatal asphyxia, a major cause of neonatal death, neurological behavior, and long-term disability. Currently, the diagnosis and prognosis of neonatal HIE are based on nervous system clinical manifestations, imaging and electrophysiological examination. These take time and late diagnosis allows brain injury to occur in newborns, so that infants of many brain injury missed the best treatment time, left with varying degrees of neurological sequelae.

Activities of autonomic neurotransmitters in Meibomian gland tissues are associated with menopausal dry eye.

The secretory activities of meibomian glands are regulated by the autonomic nervous system. The change in density and activity of autonomic nerves in meibomian glands during menopause play an important role in the pathogenesis of dry eye. In view of this, we established a dry eye rat model by removing the bilateral ovaries.

Piperazine-1,4-diium (R)-2-[4-(1-car-boxy-l-atometh-oxy)phen-oxy]propano-ate.

In the anion of the title mol-ecular salt, C(4)H(12)N(2) (2+)·C(11)H(10)O(6) (2-), the two acetate groups form torsion angles of 74.1 (1) and 7.1 (1)° with the central benzene ring, and the cation exhibits a chair conformation.

2-Methyl-sulfonyl-4-(trifluoro-meth-yl)benzoic acid.

In the title mol-ecule, C(9)H(7)F(3)O(4)S, the S and the methyl C atoms of the methyl-sulfonyl group deviate from the benzene ring plane by 0.185 (2) and -1.394 (3) Å, respectively.

2-(4-Isopropyl-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)-5-methyl-nicotinic acid.

In the title herbicideh/phytocide, known as imaza-pic, C(14)H(17)N(3)O(3), the pyridine and imidazole rings are almost coplanar [dihedral angle = 3.08 (5)°]. An intra-molecular O-H⋯N hydrogen bond occurs.

4-(2,3-Dimeth-oxy-phen-yl)-1H-pyrrole-3-carbonitrile.

The asymmetric unit of the title compound, C(13)H(12)N(2)O(2), obtained in a search for analogs of the fungicide fludioxonil [systematic name: 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile], contains two independent mol-ecules, A and B. The benzene and pyrrole rings are inclined to each other at 38.5 (1) and 29.

catena-Poly[(dichloridozinc)-μ-1-{4-[(1H-imidazol-1-yl)meth-yl]benz-yl}-1H-imidazole-κ(2)N(3):N(3')].

The asymmetric unit of the title compound, [ZnCl(2)(C(14)H(14)N(4))](n), contains a Zn(II) ion situated on a twofold rotation axis and one-half of a 1-{4-[(1H-imidazol-1-yl)meth-yl]benz-yl}-1H-imidazole (L) ligand with the benzene ring situated on an inversion center. The Zn(II) ion is coordinated by two chloride anions and two N atoms from two L ligands in a distorted tetra-hedral geometry. The L ligands bridge ZnCl(2) fragments into polymeric chains parallel to [20-1].