Publications by authors named "Jinru Xie"
Background: Oral microbiome has been associated with various cancers, including nasopharyngeal carcinoma (NPC), but its role in cancer treatment and prognosis remains largely unknown. This study aims to address the dynamic changes in oral microbiome following cancer treatment and their prognostic implications in NPC patients.
Patients And Methods: Unstimulated whole saliva samples were collected from 23 NPC patients before and after treatment, with an average of 2.
Article Synopsis
- The study explores the link between oral microbes and their potential role in developing nasopharyngeal carcinoma (NPC), revealing that these microbes can migrate from the mouth to the nasopharynx.
- It found an increased risk of NPC associated with oral-to-nasopharyngeal microbial translocation, with certain species like Fusobacterium nucleatum identified as prevalent in NPC patients.
- Additionally, the presence of these oral microbes in tumors influences the local environment and interacts with Epstein-Barr virus (EBV) loads, suggesting a complex relationship in cancer development.
Article Synopsis
- This study explored the link between oral hygiene, the oral microbiome, and nasopharyngeal carcinoma (NPC) by analyzing 218 NPC patients and 192 healthy individuals.
- Researchers used advanced gene sequencing to evaluate the oral microbiome and found that poor oral hygiene and dental fillings were associated with a higher risk of NPC.
- The analysis suggested that changes in the oral microbiome due to poor oral hygiene could partly explain the increased risk of NPC, shedding light on the underlying mechanisms at play.
Article Synopsis
- The MRN complex is essential for sensing DNA double-strand breaks (DSBs) and triggering repair signaling, but how it gets recruited needs more study.* -
- Researchers discovered that the TRIM24 protein, linked to cancer, plays a key role in recruiting the MRN complex to DSB sites and activating the repair process.* -
- TRIM24's phosphorylation by ATM is crucial for its function, and reducing TRIM24 levels increases the susceptibility of cancer cells to treatment and slows tumor growth, indicating it could be a target for future cancer therapies.*
Acinetobacter baumannii is an important opportunistic pathogen of nosocomial infections. A. baumannii presently exhibits increasing antibiotic resistance, which poses great challenges to public health.
View Article and Find Full Text PDFUnlabelled: DEAD-box RNA helicases belong to a large group of RNA-processing factors and play vital roles unwinding RNA helices and in ribosomal RNA biogenesis. Emerging evidence indicates that RNA helicases are associated with genome stability, yet the mechanisms behind this association remain poorly understood. In this study, we performed a comprehensive analysis of RNA helicases using multiplatform proteogenomic databases.
View Article and Find Full Text PDFLow Expression of ECT2 Confers Radiation Therapy Resistance Through Transcription Coupled Nucleolar DNA Damage Repair.
Int J Radiat Oncol Biol Phys
April 2022
Purpose: Radioresistance contributes to poor clinical therapeutic efficacy in most cancers. Emerging evidence shows that aberrant DNA damage repair is involved in radioresistance. This study aimed to elucidate the mechanism for radioresistance and explore the precise treatment to sensitize the radioresistant tumors.
View Article and Find Full Text PDF[Visualization analysis of traditional Chinese medicine for neurogenesis research based on CiteSpace].
Zhongguo Zhong Yao Za Zhi
September 2021
Article Synopsis
- The study used CiteSpace software to analyze the trends and hotspots in traditional Chinese medicine (TCM) research related to neurogenesis from 1987 to 2020, focusing on bibliometric data from the CNKI database.
- A total of 736 publications were reviewed, revealing a general upward trend in annual publications and the formation of stable research teams, primarily led by researchers such as DING Fei and ZHOU Chong-jian.
- Key areas of focus in TCM research for neurogenesis included disease treatment, therapeutic methods, and molecular mechanisms, with predictions that future research will increasingly target TCM therapies and their molecular impacts on the central nervous system.
Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.
Proc Natl Acad Sci U S A
October 2020
Understanding differences in DNA double-strand break (DSB) repair between tumor and normal tissues would provide a rationale for developing DNA repair-targeted cancer therapy. Here, using knock-in mouse models for measuring the efficiency of two DSB repair pathways, homologous recombination (HR) and nonhomologous end-joining (NHEJ), we demonstrated that both pathways are up-regulated in hepatocellular carcinoma (HCC) compared with adjacent normal tissues due to altered expression of DNA repair factors, including PARP1 and DNA-PKcs. Surprisingly, inhibiting PARP1 with olaparib abrogated HR repair in HCC.
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