The role of ROS-pyroptosis in PM induced air-blood barrier destruction.

Fine particulate matter (PM) has attracted increasing attention due to its health-threatening effects. Although numerous studies have investigated the impact of PM on lung injuries, the specific mechanisms underlying the damage to the air-blood barrier after exposure to PM remain unclear. In this study, we established an in vitro co-culture system using lung epithelial cells and capillary endothelial cells.

PM induce myocardial injury in hyperlipidemic mice through ROS-pyroptosis signaling pathway.

Exposure to particulate matters with diameters below 2.5 µm (PM) is considered a major risk factor for cardiovascular diseases (CVDs). The closest associations between PM and CVDs have been observed in hyperbetalipoproteinemia cases, although the detailed underpinning mechanism remains undefined.