Systemic loss of CD36 aggravates NAFLD-related HCC through MEK1/2-ERK1/2 signaling pathway.

Background & Aims: CD36, a membrane protein widely present in various tissues, is crucial role in regulating energy metabolism. The rise of HCC as a notable outcome of NAFLD is becoming more apparent. Patients with hereditary CD36 deficiency are at increased risk of NAFLD.

The predictive, preventive, and personalized medicine of insomnia: gut microbiota and inflammation.

Background: The human gut microbiota (GM) has been recognized as a significant factor in the development of insomnia, primarily through inflammatory pathways, making it a promising target for therapeutic interventions. Considering the principles of primary prediction, targeted prevention, and personalized treatment medicine (PPPM), identifying specific gut microbiota associated with insomnia and exploring the underlying mechanisms comprehensively are crucial steps towards achieving primary prediction, targeted prevention, and personalized treatment of insomnia.

Working Hypothesis And Methodology: We hypothesized that alterations in the composition of specific GM could induce insomnia through an inflammatory response, which postulates the existence of a GM-inflammation-insomnia pathway.

Global dynamics of COVID-19 epidemic model with recessive infection and isolation.

In this paper, we present an SEIIaHR epidemic model to study the influence of recessive infection and isolation in the spread of COVID-19. We first prove that the infection-free equilibrium is globally asymptotically stable with condition R<1 and the positive equilibrium is uniformly persistent when the condition R>1. By using the COVID-19 data in India, we then give numerical simulations to illustrate our results and carry out some sensitivity analysis.

Modelling seasonal HFMD with the recessive infection in Shandong, China.

Hand, foot and mouth disease (HFMD) is one of the major public-health problems in China. Based on the HFMD data of the Department of Health of Shandong Province, we propose a dynamic model with periodic transmission rates to investigate the seasonal HFMD. After evaluating the basic reproduction number, we analyze the dynamical behaviors of the model and simulate the HFMD data of Shandong Province.