Overexpression of NOP58 as a Prognostic Marker in Hepatocellular Carcinoma: A TCGA Data-Based Analysis.

Introduction: NOP58 ribonucleoprotein, a core component of box C/D small nucleolar ribonucleoproteins, is involved in various cell physiological processes. However, its role in hepatocellular carcinoma (HCC) remains very unclear. We aim to investigate NOP58 expression and its probable prognostic value in patients with HCC based on The Cancer Genome Atlas (TCGA) database.

Expression and clinical significance of the long non-coding RNA PVT1 in human gastric cancer.

Background: Highly sensitive markers are urgently needed for the diagnosis and grading of gastric cancer and for managing drug resistance. The recent identification of long-non-coding RNAs (lncRNAs) has provided new approaches for resolving this challenge. The aim of this study was to screen and identify new biomarkers for human gastric cancer from lncRNAs.

A redox active proton transfer and hydrogen-bonding system of tetrathiafulvalene-dicarboxylic acid and pyridine bases.

Hydrogen bonds are important in supramolecular chemistry and responsible for proton transfer processes. This manuscript reports new hydrogen-bonding systems of redox-active acid-base assemblies consisting of dimethylthio-tetrathiafulvalene dicarboxylic acid (H(2)L) coupled with pyridine (py), 2,2'-bipyridine (2,2'-bpy), and 4,4'-bipyridine (4,4'-bpy). The (1)H NMR chemical shifts of the pyridines and the redox potential shifts of the tetrathiafulvalene moiety indicate that proton-transfer and strong hydrogen-bonding interactions exist between the acid and the bases in aprotic solvents.

Metal-carboxylate coordination polymers with redox-active moiety of tetrathiafulvalene (TTF).

Though numerous metal-organic frameworks or polymers have been reported, the organic building blocks are usually not redox-active. On the other hand, some mono-, di- or tri-nuclear compounds with tetrathiafulvalene (TTF) have been prepared, although little is known about the coordination polymers combined with paramagnetic metals and organic TTF ligands. We report herein a series of coordination polymers of copper(II) and manganese(II) with TTF dicarboxylate ligand (L).

Cu(II) and Ni(II) dioxotetraamine complexes integrated with tetrathiafulvalene moiety; structures and solution chemistry.

A new bifunctional tetrathiafulvalene (TTF) derivative has been designed and synthesized, in which the TTF moiety (a redox functional group) is integrated with a dioxotetraamine (a coordination functional group) structure. Like other dioxotetraamine compounds, it is capable of acting as an ion leaving and accepting ligand for protons and Cu(II) and Ni(II) ions in solution. Experiments of pH titration have shown that the TTF unit adds new redox properties to the traditional ligand.

Triadic intramolecular charge transfer compound of tetrathiafulvalene exhibiting multicolor solvatochromism.

An A-D-A triad compound comprising a tetrathiafulvalene (TTF) moiety and two pyridyl groups, py-TTF-py (1), has been studied in view of intramolecular charge transfer (ICT). The compound shows a sharp and multicolor change in different solvents and at different pH values, exhibiting good solvatochromism. The results of electronic absorption spectroscopy, cyclic voltammetry, and theoretical calculations confirm that there exists predominantly a monoprotonated A-D-A triad that displays a strong ICT effect, which is tunable as a function of pH.