Biomechanics of extreme lateral interbody fusion with different internal fixation methods: a finite element analysis.

Background: Establishing a normal L3-5 model and using finite element analysis to explore the biomechanical characteristics of extreme lateral interbody fusion (XLIF) with different internal fixation methods.

Method: The L3-5 CT image data of a healthy adult male volunteer were selected to establish a normal lumbar finite element model (M0). The range of motion (ROM) of L3-4 and L4-5, under flexion, extension, left bending, right bending, left rotation, and right rotation, together with L3-4 disc pressure was analyzed.

Dynamic heterogeneity and collective motion in star polymer melts.

While glass formation of linear chain polymer melts has widely been explored, comparatively little is known about glass formation in star polymer melts. We study the segmental dynamics of star polymer melts via molecular dynamics simulations and examine the cooperative nature of segmental motion in star melts. In particular, we quantify how the molecular architecture of star polymers, i.

FoxM1 involvement in astrocyte proliferation after spinal cord injury in rats.

The Forkhead box M1 (FoxM1) protein is a proliferation-associated transcription factor that plays a key role in controlling both the G1/S and G2/M transitions of the cell cycle and regulates transcription of cell cycle genes, including cyclin-dependent kinase inhibitors p27(kip1) and p21(waf1/cip1). The expression levels of FoxM1 directly correlated with the proliferation index, cancer survival, genomic instability rate, and microvessel density, and inversely correlated with apoptosis. Furthermore, FoxM1 is determined to play a role in tissue repair following injury in the lungs and liver.

FOXO3a/p27kip1 expression and essential role after acute spinal cord injury in adult rat.

FOXO3a (Forkhead Class box O3a), as an important direct target of the phosphatidylinositol 3-kinase (PI3K)/protein B (Akt) pathway, which regulates the cell survival and the cell-cycle progression. Recent reports showed that FOXO3a could inhibit cell-cycle progression at the G1/S transition by controlling transcription of the cyclin-dependent kinase inhibitor p27(kip1) , which is also a key regulator of the mammalian neurogenesis. To elucidate the expression and role of FOXO3a in nervous system lesion and repair, we performed an acute spinal cord contusion injury (SCI) model in adult rats, which showed a temporal-spatial expression pattern of FOXO3a.