An Iris Tumor Secondary to Infection in a Patient with AIDS and Syphilis.

Purpose: To report a case of iris tumor secondary to infection in a patient with AIDS and syphilis.

Case Report: A 25-year-old man presented with gradual vision decrease in the right eye for 2 months. Ocular examination revealed best-corrected visual acuity (BCVA) of 0.

Validated LC-MS/MS methods for the determination of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor in normal and ZDF rat plasma.

Background: Dapagliflozin is an inhibitor of sodium-glucose co-transporter 2 (SGLT-2) in development for the treatment of Type 2 diabetes. To support toxicology studies, LC-MS/MS methods were developed and validated for the quantitation of dapagliflozin in rat plasma.

Results: The assay uses solid phase extraction and LC-MS/MS analysis in negative ion electrospray ionization mode.