Publications by authors named "Jinna Zhang"

Within the context of circular economy and industrial ecology, adsorption offers an effective manner for recycling resources from wastewater, but controllable desorption remains a challenge. Inspired by metal-thiol binding and reversible thiol-disulfide redox transformation in biological systems, this study reports the development of a reversible adsorption/desorption (RAD) system for controllable recovery of copper based on electrochemically switchable sulfurized polyacrylonitrile (SPAN). Density functional theory calculations offered theoretical prediction for the formation of S-Cu bonds and reversible weak interaction between S-S bonds and Cu.

View Article and Find Full Text PDF

Background: Targeting DNA damage repair factors, such as DNA-dependent protein kinase catalytic subunit (DNA-PKcs), may offer an opportunity for effective treatment of multiple myeloma (MM). In combination with DNA damage-inducing agents, this strategy has been shown to improve chemotherapies partially via activation of cGAS-STING pathway by an elevated level of cytosolic DNA. However, as cGAS is primarily sequestered by chromatin in the nucleus, it remains unclear how cGAS is released from chromatin and translocated into the cytoplasm upon DNA damage, leading to cGAS-STING activation.

View Article and Find Full Text PDF

Recovery of ammonium from wastewater represents a sustainable strategy within the context of global resource depletion, environmental pollution and carbon neutralization. The present study developed an advanced self-reporting electroswitchable colorimetric platform (SECP) to realize smart ammonium recovery based on the electrically stimulated transformation of Prussian blue/Prussian white (PB/PW) redox couple. The key to SECP was the selectivity of ammonium adsorption, sensitivity of desorption to electric signals and visualability of color change during switchable adsorption/desorption transformation.

View Article and Find Full Text PDF

Introduction: Multiple targets are considered as the causes of ambient fine particulate matter [aerodynamic diameters of < 2.5 μm (PM)] induced lung function injury. Qiju granules are derived from the traditional Chinese medicine (TCM) formula known as Qi-Ju-Di-Huang-Wan (Lycium, Chrysanthemum, and Rehmannia Formula, QJDHW), which has been traditionally used to treat symptoms such as cough with phlegm, dry mouth and throat, and liver heat.

View Article and Find Full Text PDF

Objective: To analyze the factors that might influence the pregnancy rate in patients with infertility related to endometriosis (EMs) after undergoing laparoscopic surgery, providing guidance for our clinical diagnostic and therapeutic decision-making.

Methods: A retrospective analysis was conducted on clinical records and 1-year postoperative pregnancy outcomes of 335 patients diagnosed with endometriosis-related infertility via laparoscopic surgery, admitted to our department from January 2018 to December 2020.

Results: The overall pregnancy rate for patients with endometriosis (EMs) related infertility 1-year post-surgery was 57.

View Article and Find Full Text PDF

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-Q) is an ozonation product of the rubber antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD). 6PPD-Q has recently been detected in various environmental media, which may enter the human body via inhalation and skin contact pathways. However, the human metabolism of 6PPD-Q has remained unknown.

View Article and Find Full Text PDF
Article Synopsis
  • Researchers developed high-performance organic solar cells (OSCs) using a dual-anode interface made of PEDOT:PSS and Br-2PACz, which enhanced both current and fill factor significantly.
  • The improvements in device performance were linked to better interface conductivity, increased hole mobility, and optimized morphology, leading to a current density of 27.84 mA/cm² and a fill factor of 78.18%.
  • Additionally, the OSCs showed great stability, retaining 94.7% of their initial efficiency after 500 hours in a nitrogen environment, indicating the effectiveness of the dual-anode strategy for improving OSC performance.
View Article and Find Full Text PDF
Article Synopsis
  • - **Psychotropic medications are widely prescribed but can harm the environment, leading to a need for effective detection methods.**
  • The study created a reliable method using ultra-performance liquid chromatography to analyze 47 psychotropic drugs across various water and sludge samples.
  • The findings showed that many of these medications persist in wastewater treatment plants, highlighting issues with their removal and potential environmental impact.
View Article and Find Full Text PDF

Electrochemical advanced oxidation process (EAOP) is a promising technology for decentralized water decontamination but is subject to parasitic anodic oxygen evolution and formation of toxic chlorinated byproducts in the presence of Cl. To address this issue, we developed a novel electrolytic process by water flow-driven coupling of anodic oxygen evolution reaction (OER) and cathodic molecular oxygen activation (MOA). When water flows from anode to cathode, O produced from OER is carried by water through convection, followed by being activated by atomic hydrogen (H*) on Pd cathode to produce OH.

View Article and Find Full Text PDF

Aim: This study aimed to identify the molecular type and prognostic model of lung adenocarcinoma (LUAD) based on cancer stem cell-related genes. Studies have shown that cancer stem cells (CSC) are involved in the development, recurrence, metastasis, and drug resistance of tumors.

Method: The clinical information and RNA-seq of LUAD were obtained from the TCGA database.

View Article and Find Full Text PDF

CUDC-101, an effective and multi-target inhibitor of epidermal growth factor receptor (EGFR), histone deacetylase (HDAC), and human epidermal growth factor receptor 2 (HER2), has been reported to inhibit many kinds of cancers, such as acute promyelocytic leukemia and non-Hodgkin's lymphoma. However, no studies have yet investigated whether CUDC-101 is effective against myeloma. Herein, we proved that CUDC-101 effectively inhibits the proliferation of multiple myeloma (MM) cell lines and induces cell apoptosis in a time- and dose-dependent manner.

View Article and Find Full Text PDF

There is always a dilemma between strong π-π stacking/crystallinity and suitable domain size for all-small-molecule organic solar cells (ASM-OSCs), which puts forward higher requirements for the design of molecular donors. In this work, a series of novel molecular donors with different positional 2-ethylhexy (EH) attachments are designed and synthesized, named SM-R, SM-REH, SM-EH-R, and SM-EH-REH. It is found that EH-substitution on end groups (SM-REH) enables improved π-π interaction and crystallinity but with decreased solubility and phase size, leading to the improved efficiency of 15.

View Article and Find Full Text PDF

Waterborne pathogens have the risk of spreading waterborne diseases and even pandemics. Some Gram-positive bacteria can form endospores, the hardiest known life form that can withstand heat, radiation, and chemicals. Electrochemical inactivation may offer a promising solution, but is hindered by low inactivation efficiencies resulting from limitation of electrode/endospores interaction in terms of electrochemical reaction selectivity and mass transfer.

View Article and Find Full Text PDF

Direct cultivation of aerobic granular sludge (AGS) in membrane bioreactor (MBR) has gained increasing attention. Mycelial pellets (MPs) has been shown capable of promoting rapid granulation of aerobic sludge in MBR, yet mechanisms remain unclear and in-depth insight into cross-scale interactions between MPs and indigenous microbiota as well as the corresponding protein expression functions is necessary. Herein, we found that the addition of MPs in MBR resulted in massive growth of metazoans with 40-400 /mL for rotifers, 20-140 /mL for nematodes and 2-420 /mL for oligochaetes in the initial phase of granulation.

View Article and Find Full Text PDF

Background: Multiple myeloma (MM) is a malignant proliferative disease of the blood system, characterized by the abnormal growth of clonal plasma cells in the bone marrow. The bone marrow microenvironment (BMM) is highly critical in the pathological process of MM. Many studies have shown that serum interleukin-17A (IL-17A) plays a key role in various infectious diseases, autoimmune diseases, and cancers.

View Article and Find Full Text PDF

Global climate warming has drawn worldwide attention. However, the health impact of heat exposure is still controversial. This study aimed to explore the exact effects and sex differential vulnerability under intermittent heat exposure (IHE) patterns and tried to elucidate the potential mechanisms by which IHE modulated hepatic lipid and glucose homeostasis.

View Article and Find Full Text PDF

Background: Due to post-cleavage residence of the Cas9-sgRNA complex at its target, Cas9-induced DNA double-strand breaks (DSBs) have to be exposed to engage DSB repair pathways. Target interaction of Cas9-sgRNA determines its target binding affinity and modulates its post-cleavage target residence duration and exposure of Cas9-induced DSBs. This exposure, via different mechanisms, may initiate variable DNA damage responses, influencing DSB repair pathway choices and contributing to mutational heterogeneity in genome editing.

View Article and Find Full Text PDF

Fine particulate matter (PM) is well known to impair lung function. Strategies protecting against PM-exerted lung dysfunction have been less investigated. Qianjinweijing decoction (QJWJ), a decoction of a herbal medicine of natural origin, has been used to treat lung disorders as it inhibits oxidation and inflammation.

View Article and Find Full Text PDF

Purpose: The purpose of this study was to investigate and analyze the level of actual participation and perceived importance of shared decision-making on treatment and care of lung cancer patients, to compare their differences and to explore their influencing factors.

Methods: A total of 290 lung cancer patients were collected from oncology and thoracic surgery departments of a comprehensive medical center in Qingdao from October 2018 to December 2019. Participants completed a cross-sectional questionnaire to assess their actual participation and perceived importance in shared decision-making on treatment and care.

View Article and Find Full Text PDF

Multiple myeloma (MM) is an incurable plasma cell hematological malignancy. Bortezomib has become the primary drug in the treatment of patients with MM. However, its negative effects, especially peripheral neuropathy (PN), affect the patients' life quality and treatment continuity.

View Article and Find Full Text PDF

Benzotriazole (BTA) is a widely used anticorrosive additive that is of endurance, bioaccumulation and toxicity, and BTA industrial wastewater treatment remains a challenge. This study reports efficient electrochemical removal of BTA by titanium oxide (TiSO) electroactive ceramic membrane (ECM), indicated by 98.1% removal at current density of 20 mA∙cm-2 and permeate flux of 692 LHM under cathode-to-anode flow pattern (1 h).

View Article and Find Full Text PDF

Multiple myeloma (MM) is characterized by an accumulation of monoclonal plasma cells within the bone marrow (BM). Macrophages are an abundant component of myeloma BM microenvironment and support survival of the malignant cells and foster myeloma development and progression by suppression of the immune response. In our previous study, we found that MM patients overexpress pro-inflammatory cytokine interleukin-32 (IL-32).

View Article and Find Full Text PDF

This publication has been retracted by the Editor due to the identification of falsified figure images and manuscript content that raise concerns regarding the credibility of the study and the manuscript. Reference: Vemurafenib Hao Song, Jinna Zhang, Liang Ning, Honglai Zhang, Dong Chen, Xuelong Jiao, Kejun Zhang. The MEK1/2 Inhibitor AZD6244 Sensitizes BRAF-Mutant Thyroid Cancer to Vemurafenib.

View Article and Find Full Text PDF