Discovery of thioetomidate derivatives as rapid recovery hypnotics without adrenocortical suppression.

Intravenous anesthetics play a crucial role during surgery. Etomidate, a commonly used intravenous anesthetic agent, is prized for its rapid onset and smooth induction of anesthesia. However, it has a pronounced adverse effect on adrenal function suppression.

Field detection of multiple RNA viruses/viroids in apple using a CRISPR/Cas12a-based visual assay.

Co-infection of apple trees with several viruses/viroids is common and decreases fruit yield and quality. Accurate and rapid detection of these viral pathogens helps to reduce losses and prevent virus spread. Current molecular detection assays used for apple viruses require specialized and expensive equipment.