Sinomenine modulates the metabolic reprogramming induced by sepsis via CHRNA7.

Background And Purpose: Sepsis is a condition capable of causing systemic inflammation and metabolic reprogramming. Previous studies have shown that sinomenine (SIN) can mitigate sepsis by reducing inflammation, while the effect on metabolic reprogramming is unclear. The aim of this study is to investigate the function of SIN in metabolic reprogramming in sepsis.

Multifunctional hydrogels for the healing of oral ulcers.

Oral ulcers are one of the most common oral diseases in clinical practice. Its etiology is complex and varied. Due to the dynamic nature of the oral environment, the wound surface is painful due to contact and wear, which seriously affects the quality of life of patients.

Evolution Law of Concrete Interface Stress of Rigid-Frame Arch under Construction and Its Impact on Ultimate Load-Bearing Capacity.

To study the evolution of stress on the ring and segment interfaces during the construction process of the concrete encapsulation of the main arch ring in a rigid-frame arch bridge, alongside its impact on the ultimate load-bearing capacity of the main arch ring, a 1:10 scale model experiment was conducted by taking the 600 m Tian'e Longtan Bridge as the prototype. The key cross-section concrete strain data were collected during the entire construction process of the main arch ring via fiber-optic strain sensors, which were used to investigate the stress evolution at ring and segment interfaces. ANSYS APDL was employed to simulate the ultimate bearing capacity under various loading conditions of two different finite element models, which were, respectively, formed segmentally and by single pouring.

Investigating side chain mediated electroluminescence from carbazole-modified polyfluorene.

In molecular design of electroluminescent (EL) conjugated polymers, introducing a charge transport moiety on a side chain is found to be a promising method for balancing electron and hole fluxes in EL devices without changing the emitting color if there is no interaction between moiety and main chain. In the case of grafting a carbazole (Cz) moiety (hole transporting) on blue emitting polyfluorene, a green emission appears with intensity comparable to the blue emission, which was attributed to a possible interaction between main chain and Cz as previously reported by us. Here, a detailed study of its EL mechanism was carried out by means of time-resolved EL with the assistance of molecular simulation and thermally stimulated current measurements; exploration of how main chain segments interact with the transport moiety was performed.

Green emission from end-group-enhanced aggregation in polydioctylfluorene.

Green emission in polyfluorenes (PFs) has been attributed to aggregation or excimer emission, but recently it was reassigned as an on-chain fluorenone defect. We show here that, in dialkyl-substituted PFs that is hydrogen-free at the 9'-position of the fluorene, blue emission with very weak green emission is observed from end-capped polydioctylfluorene (PFO) for both photoluminescence and electroluminescence spectra, while the low-energy green emission at 507 nm is very pronounced only in uncapped PFO (PFOun). The facts that there is no detectable infrared absorption at around 1721 cm(-1) due to >C=O stretching vibration in PFOun and no charge-trapping occurring in the light-emitting device from PFOun are in contrast with those found in the literature-reported copolymers with fluorenone units, which have detectable infrared absorption at 1721 cm(-1) and charge-trapping in devices.

Fine tuning the purity of blue emission from polydioctylfluorene by end-capping with electron-deficient moieties.

We propose a simple way to achieve pure blue emission and improved device efficiency via capping poly(9,9-dioctylfluorene) (PFO) with electron-deficient moieties (EDMs, such as oxadiazole (OXD) and triazole (TAZ)), which can induce a minor amount of long conjugating length species (regarded as beta phase) to control extents of energy transfer from amorphous matrix to the beta phase. The device efficiency of PFO end-capped with TAZ is higher than that with para-tert-butyl phenyl (TBP) by a factor of 2 (with CsF/Al as cathode), and its electroluminescent spectrum remains stable and with pure blue emission during cyclic operations (C.I.

High-efficiency red-light emission from polyfluorenes grafted with cyclometalated iridium complexes and charge transport moiety.

We report a new route for the design of electroluminescent polymers by grafting high-efficiency phosphorescent organometallic complexes as dopants and charge transport moieties onto alky side chains of fully conjugated polymers for polymer light-emitting diodes (PLED) with single layer/single polymers. The polymer system studied involves polyfluorene (PF) as the base conjugated polymer, carbazole (Cz) as the charge transport moiety and a source for green emission by forming an electroplex with the PF main chain, and cyclometalated iridium (Ir) complexes as the phosphorescent dopant. Energy transfer from the green Ir complex or an electroplex formed between the fluorene main chain and side-chain carbazole moieties, in addition to that from the PF main chain, to the red Ir complex can significantly enhance the device performance, and a red light-emitting device with the high efficiency 2.