Bioprinted Fibroblast Mediated Heterogeneous Tumor Microenvironment for Studying Tumor-Stroma Interaction and Drug Screening.

Cancer-associated fibroblasts (CAFs) are crucial stromal cells in the tumor microenvironment, affecting cancer growth, angiogenesis, and matrix remodeling. Developing an effective in vitro tumor model that accurately recapitulates the dynamic interplay between tumor and stromal cells remains a challenge. In this study, a 3D bioprinted fibroblast - mediated heterogeneous breast tumor model was created, with tumor cells and fibroblasts in a bionic matrix.

Minute-Level Room-Temperature Switching and Long Cycle Stability of Thermochromic Inorganic Perovskite Smart Windows.

Perovskite smart windows (PSWs) are widely investigated owing to excellent thermochromic properties, while restricted by poor transition performance and cycle stability. Herein, dimethyl sulfoxide vapor is utilized as an induction reagent for rapid reversible switching at room temperature between the colored and bleached phases. To obtain PSWs with different optical properties and transition performance, red CsPbIBr, yellow RbCsPbIBr and brown CsSnPbIBr are prepared through alloying.

Constructing Bionic Perovskite Smart Photovoltaic Windows with Switchable Colors and High Cycling Stability.

Smart photovoltaic windows (SPWs) provide a high-efficiency and energy-saving strategy owing to the dual capabilities of electricity generation and sunlight modulation achieved by tunable colors and transmittances. Due to the deterioration of chromic process on photovoltaic layers, SPWs usually suffer from poor cycling stability. Moreover, thermochromic SPWs with a multilayer structure usually change transmittance without reversible color transitions.

3D bioprinting platform development for high-throughput cancer organoid models construction and drug evaluation.

The evaluation of anti-tumor drugs is critical for their development and clinical guidance. Tumor organoid models are gaining increased attention due to their ability to better mimic real tumor tissues, as well as lower time and economic costs, which makes up for the shortcomings of cell lines and xenograft models. However, current tumor organoid cultures based on the Matrigel have limitations in matching with high-throughput engineering methods due to slow gelation and low mechanical strength.

Single-Atom Ni Supported on TiO for Catalyzing Hydrogen Storage in MgH.

As an efficient and clean energy carrier, hydrogen is expected to play a key role in future energy systems. However, hydrogen-storage technology must be safe with a high hydrogen-storage density, which is difficult to achieve. MgH is a promising solid-state hydrogen-storage material owing to its large hydrogen-storage capacity (7.

Injectable Hydrogel Delivery System with High Drug Loading for Prolonging Local Anesthesia.

Peripheral nerve block is performed for precise pain control and lesser side effects after surgery by reducing opioid consumption. Injectable hydrogel delivery systems with high biosafety and moisture content have good clinical application prospects for local anesthetic delivery. However, how to achieve high drug loading and long-term controlled release of water-soluble narcotic drugs remains a big challenge.

3D printed heterogeneous hybrid hydrogel scaffolds for sequential tumor photothermal-chemotherapy and wound healing.

Surgical resection remains the mainstay of melanoma treatment. However, due to the difficulties in controlling tumor recurrence and wound healing simultaneously, high postoperative recurrence rates and wound reconstruction remain the most significant challenges. As a result, a heterogeneous hybrid hydrogel scaffold was designed in this work to achieve sequential photothermal therapy and chemotherapy for melanoma recurrence inhibition and wound healing.

Elevated miR-195-5p expression in deep vein thrombosis and mechanism of action in the regulation of vascular endothelial cell physiology.

Deep vein thrombosis (DVT) is one of the most common cardiovascular diseases. The apoptosis of vascular endothelial cells is the most important cause of venous thrombosis. MicroRNAs (miRNAs) play important roles in the regulation of cell apoptosis.

Enhanced ROS production leads to excessive fat accumulation through DAF-16 in Caenorhabditis elegans.

Growing evidence shows that enhanced reactive oxygen species (ROS) production is an important contributor to obesity and its co-morbidities, but the functional link between ROS and obesity remains elusive. In this study we used the model animal Caenorhabditis elegans to explore the role of ROS in obesity. Initially, when ROS production was enhanced by treatment with low concentration of paraquat or juglone, both abnormal high fat accumulation and fatty acid composition were observed in wild type worms.