A combined model integrating radiomics and deep learning based on multiparametric magnetic resonance imaging for classification of brain metastases.

Background: Radiomics and deep learning (DL) can individually and efficiently identify the pathological type of brain metastases (BMs).

Purpose: To investigate the feasibility of utilizing multi-parametric MRI-based deep transfer learning radiomics (DTLR) for the classification of lung adenocarcinoma (LUAD) and non-LUAD BMs.

Material And Methods: A retrospective analysis was performed on 342 patients with 1389 BMs.

2.5D deep learning based on multi-parameter MRI to differentiate primary lung cancer pathological subtypes in patients with brain metastases.

Background: Brain metastases (BMs) represents a severe neurological complication stemming from cancers originating from various sources. It is a highly challenging clinical task to accurately distinguish the pathological subtypes of brain metastatic tumors from lung cancer (LC).The utility of 2.

Information-motivation-behavioral guided nursing for stroke patients with pulmonary dysfunction: A randomized controlled trial.

Background: Patients with stroke frequently experience pulmonary dysfunction.

Aim: To explore the effects of information-motivation-behavioral (IMB) skills model-based nursing care on pulmonary function, blood gas indices, complication rates, and quality of life (QoL) in stroke patients with pulmonary dysfunction.

Methods: We conducted a controlled study involving 120 stroke patients with pulmonary dysfunction.

Study on predictive models for swallowing risk in patients with AECOPD.

Background: Dysphagia is considered a complication in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, AECOPD may have risk factors for dysphagia.

Methods: Through a cross-sectional study, which included 100 patients with AECOPD.

Submerged macrophyte promoted nitrogen removal function of biofilms in constructed wetland.

Biofilm is one of the important factors affecting nitrogen removal in constructed wetlands (CWs). However, the impact of submerged macrophyte on nitrogen conversion of biofilms on leaf of submerged macrophyte and matrix remains poorly understood. In this study, the CWs with Vallisneria natans and with artificial plant were established to investigate the effects of submerged macrophyte on nitrogen conversion and the composition of nitrogen-converting bacteria in leaf and matrix biofilms under high ammonium nitrogen (NH-N) loading.

Polyphosphate promotes oxidation resistance of ppk-expressing transgenic rice in low phosphorus culture.

Phosphorus (P) plays a crucial role in plant growth. Insufficient availability of inorganic phosphate (Pi) can significantly impact crop yields. To address this, we previously developed transgenic rice expressing the low polyphosphate kinase gene (ppk) - known as ETRS - to enhance the efficiency of P resource utilization.

The ppk-expressing transgenic rice floating bed improves P removal in slightly polluted water.

With significant economic advantages, the plant floating bed has been widely utilized in the ecological remediation of eutrophic water because of the excessive phosphorus (P) and nitrogen discharge in China. Previous research has demonstrated that polyphosphate kinase (ppk)-expressing transgenic rice (Oryza sativa L. ssp.

IntelliSense Bio-Ionotronics Battery for Early Warning of Geological Seepage.

Water seepage-induced geological hazards (SIGHs), including landslides, collapse, debris flow, and ground fissures, often cause substantial human mortality, economic losses, and environmental damage. However, an early warning of geological water seepage remains a significant challenge. A self-powered, cost-effective, reliable, and susceptible SIGH early warning system (SIGH-EWS) is reported herein.

Global research trends in atherosclerosis-related NF-κB: a bibliometric analysis from 2000 to 2021 and suggestions for future research.

Background: Atherosclerosis (AS) is closely related to stroke and cardiovascular diseases. Nuclear factor kappa-B (NF-κB) is the master regulator of inflammation, and thus, modulating the transcription of NF-κB can improve AS.

Methods: In this study, we conducted a bibliometric analysis to identify the frontiers, hotspots, and features of global research output on NF-κB in AS from 2000 to 2021.

Prolonged electrolysis injures the neural development of zebrafish (Danio rerio).

Recently, electrolysis technology has been widely applied in nitrogen and phosphorus removal in river water due to its high efficiency, but its effects on aquatic animals, especially on their neurodevelopmental system, are still unclear. In this study, zebrafish (Danio rerio) embryos were used as model organisms and were put into an electrolytic reaction device with a Ti/IrO/RuO mesh plate as the anode and a Ti mesh plate as the cathode to explore the effects of prolonged electrolysis on the nervous system. The neural development of zebrafish embryos was injured when the current density was greater than 0.

Amplified cyanobacterial bloom is derived by polyphosphate accumulation triggered by ultraviolet light.

Cyanobacterial blooms appear more strongly, constantly and globally, yet the positive effect of surface solar ultraviolet radiation (UV) on cyanobacterial bloom in natural freshwater habitats is largely ignored. Here in-situ and laboratory studies were jointly designed to probe the mechanism of cyanobacterial bloom promoted by solar UV light. The results showed that solar UV light is a key trigger factor for the accumulation of total phosphorus, dissolved inorganic phosphorus and polyphosphate (polyP) in blooming cyanobacterial cells.

Correlation Analysis of Vestibular Symptoms and Migraine and Non-migraine Headaches: An Epidemiological Survey of 708 Female Nurses.

Objective: This study is oriented to study the correlation between different vestibular symptoms and migraine and non-migraine headaches.

Materials And Methods: A questionnaire containing factors related to vestibular symptoms and migraine was designed to survey nurses in a tertiary hospital. Then, all study subjects were divided into three groups: no headache, migraine, and non-migraine headache, and the general physical condition and incidence of different vestibular symptoms were compared among the three groups.

[Automatic detection model of hypertrophic cardiomyopathy based on deep convolutional neural network].

The diagnosis of hypertrophic cardiomyopathy (HCM) is of great significance for the early risk classification of sudden cardiac death and the screening of family genetic diseases. This research proposed a HCM automatic detection method based on convolution neural network (CNN) model, using single-lead electrocardiogram (ECG) signal as the research object. Firstly, the R-wave peak locations of single-lead ECG signal were determined, followed by the ECG signal segmentation and resample in units of heart beats, then a CNN model was built to automatically extract the deep features in the ECG signal and perform automatic classification and HCM detection.

Microcystin-leucine arginine (MC-LR) induces mouse ovarian inflammation by promoting granulosa cells to produce inflammatory cytokine via activation of cGAS-STING signaling.

Early experimental studies have demonstrated that microcystin-leucine arginine (MC-LR) is able to induce multiple organ damage. Female reproductive disorders caused by MC-LR have attracted increased attention in recent years. However, the underlying mechanisms of female reproductive malfunctions are not yet fully understood.

Effects of biochar on the growth of Vallisneria natans in surface flow constructed wetland.

To improve the nitrogen and phosphorus removal efficiency of surface flow constructed wetlands (SFCWs), biochar was added to an SFCW matrix. The effects of adding different amounts of biochar on water purification, the growth of Vallisneria natans (V. natans), and microbial mechanisms were explored through SFCW simulation experiments.

The mechanisms of mitochondrial dysfunction and glucose intake decrease induced by Microcystin-LR in ovarian granulosa cells.

Microcystin-LR (MC-LR) is a cyclic heptapeptide; it is an intracellular toxin released by cyanobacteria that exhibits strong reproductive toxicity. Previous studies have demonstrated that MC-LR induces oxidative stress in granulosa cells by damaging the mitochondria, which eventually leads to follicle atresia and female subfertility. In the present study, granulosa cells were exposed to 0, 0.

Effects of Hydrophilicity, Adhesion Work, and Fluid Flow on Biofilm Formation of PDMS in Microfluidic Systems.

Polydimethylsiloxane (PDMS) has been the most widely used material in microfluidic systems, especially for cell biology applications. However, the antibacterial performance of PDMS in flow conditions has never been reported in the literature. In this paper, we analyzed the effects of contact angle (CA), adhesion force (work), and surface free energy on the antibacterial activities of PDMS by varying the ratio of curing agents (crosslinking degree) and surface modification with oxygen plasma.

Prognostic Worth of Epidermal Growth Factor Receptor (EGFR) in Patients with Head and Neck Tumors.

Introduction: Head and neck tumors (HNT) are tumors that normally occur at the head and neck region of the body. Epidermal growth factor receptor (EGFR) has been found to be highly expressed in breast and other tumors; therefore, there is the need to investigate the level of EGFR expression among patients with head and neck tumors in Ghana.

Method: The level of EGFR expression was determined in head and neck tumor and control head and neck tissues with quantitative real-time PCR and immunohistochemistry analysis.

A Novel PRRT2 Variant in Chinese Patients Suffering from Paroxysmal Kinesigenic Dyskinesia with Infantile Convulsion.

PRRT2 mutations are the major causative agent of paroxysmal kinesigenic dyskinesia with infantile convulsion (PKD/IC). The study is aimed at screening PRRT2 gene mutations in patients who suffered from PKD/IC in Chinese population. Thirteen Chinese patients with PKD/IC were screened randomly for coding exons of the PRRT2 gene mutation along with 50 ethnically coordinated control people.

[Clinical efficacy of Matrine and Sodium Chloride Injection in treatment of 40 cases of COVID-19].

In this paper, we analyzed medical records of 40 patients with coronavirus disease 2019(COVID-19), in order to explore the clinical efficacy of Matrine and Sodium Chloride Injection in the treatment of COVID-19. The investigation was based on the results of a previous animal test, which was aimed to investigate and confirme the clinical efficacy of Matrine and Sodium Chloride Injection in the treatment of COVID-19. The animal test demonstrated that Matrine and Sodium Chloride Injection has a significant therapeutic effect on the human coronavirus pneumonia for the model mice.

Prenatal diagnosis of skeletal dysplasias using whole exome sequencing in China.

Background: Skeletal dysplasias account for nearly 10% of fetal structural malformations detected by ultrasonography. This clinically heterogeneous group of genetic anomaly includes at least 461 genetic skeletal disorders with extreme clinical, phenotypic, and genetic heterogeneities, thus, significantly complicates accurate diagnosis. Researches have used whole exome sequencing (WES) for prenatal molecular diagnoses of skeletal dysplasias, however, data are still limited.

Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons.

Microcystin-leucine-arginine (MC-LR) can cross the blood-brain barrier (BBB) and demonstrate potent acute hippocampal neurotoxicity. Chronic exposure to MC-LR has been confirmed to cause learning and memory deficits in mice, but the potential molecular mechanism of MC-LR-caused neurotoxicity is still unclear. In this research, we observed that MC-LR induced oxidative stress, mitochondrial fission and apoptosis in HT-22 hippocampal neurons.

MC-LR induced overproduction of progesterone via inhibiting miR-3473g: in vitro and in vivo evidence.

Health risk of human exposure to microcystin-leucine arginine (MC-LR) has drawn more and more attention in recent years. In the present study, MC-LR inhibited miR-3473g expression of mouse granulosa cells both in vitro and in vivo. By dual-luciferase reporter assay, we confirmed miR-3473g is able to bind the 3'-UTR of StAR protein (StAR) mRNA and suppress StAR expression.

Anticonvulsant and Neuroprotective Effects of Paeonol in Epileptic Rats.

Paeonol is the main active compound in the root bark extract of the peony tree, and it has antioxidative and anti-inflammatory effects. Recent studies have reported the neuroprotective effects of paeonol including its capacity in improving impaired memory. However, the effect of paeonol on epilepsy is yet to be demystified.