Study protocol on the efficacy of exergames-acceptance and commitment therapy program for the treatment of major depressive disorder: comparison with acceptance and commitment therapy alone and treatment-as-usual in a multicentre randomised controlled trial.

Background: The prevalence of major depressive disorder (MDD) is on the rise globally, and the use of antidepressant medications for its treatment does not usually result in full remission. However, the combination of physical exercise and psychotherapy for the treatment of MDD increase the rate of full remission among patients. This three-armed, parallel-group, double-blinded randomised controlled trial (RCT) aims to assess and compare the effects between the combination of exergame and acceptance and commitment therapy (e-ACT) programme, ACT only and treatment-as-usual (TAU) control groups on the severity of depression and anxiety symptoms, the degree of experiential avoidance and quality of life (QoL) and the serum levels of depression biomarkers (such as brain-derived neurotrophic factor, C-reactive protein and vascular endothelial growth factor) among patients with MDD across three time points.

Measuring spin Hall effect of light by cross-polarization intensity ratio.

We propose and realize a simple technique to measure the tiny spin Hall effect of light from the ratio of the minimum and the maximum intensities along two cross-polarization directions, without the requirement of a position-sensitive detector in the conventional weak measurement. Furthermore, the weak intensity ratio is dramatically amplified by purposely choosing the intensity along the direction close to that of the minimum instead of the maximum along the perpendicular polarization direction, which is verified by the experimental results. In principle, this method also can be modified for measurement of the high extinction ratio of a polarizer.