Publications by authors named "Jinli Lyu"
Background: Preeclampsia is a major challenge for obstetricians due to its severe impacts on maternal and fetal health. Lysine lactylation (Kla) derived from lactate is a novel type of post-translational modification which has been confirmed to affect the malignant progression of diseases as an epigenetic modifier. However, the systemic lactylome profiling of preeclampsia is still unclear.
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- Preeclampsia (PE) is a serious condition affecting pregnancy health, with limited treatment options, prompting research into new therapies targeting the role of Transgelin-2 (TAGLN2) and the Rap1 signaling pathway.
- This study used placentas from PE patients and created models by down-regulating TAGLN2 in mice and cell lines to analyze how its suppression affects PE development through molecular mechanisms.
- The results showed that down-regulation of TAGLN2 decreases the expression of Rap1A, hindering cell proliferation and migration in trophoblasts, thereby suggesting that TAGLN2’s role is significant in PE progression via the inhibition of the Rap1 signaling pathway.
Introduction: Specialized care is essential for the recovery of children with cerebral palsy (CP). This study investigates how different care modes impact the gut microbiota.
Methods: Fecal samples from 32 children were collected, among whom those cared for by family ( = 21) were selected as the observation group, and those cared for by children's welfare institutions ( = 11) were selected as the control group (registration number of LGFYYXLL-024).
Article Synopsis
- Vaginitis is linked to harmful bacteria and a lack of good lactobacilli, prompting researchers to explore lactobacilli supplementation as a treatment strategy.
- The study involved sequencing the genomes of 98 isolated strains to identify candidates for probiotics based on their genetic profiles, which included factors like metabolite production and resistance to harsh conditions.
- Two exceptional strains, LG55-27 and TM13-16, were effective in reducing bacterial vaginosis in a rat model, demonstrating their potential for both oral and vaginal treatment options.
Article Synopsis
- Bacterial vaginosis (BV) is a common infection linked to a decrease in beneficial lactobacilli in the vaginal microbiome, and this study evaluates the effectiveness of two probiotics, TM13 and LG55, alongside metronidazole (MET) in treating Chinese women with BV.
- A controlled trial with 67 participants showed that while probiotics did not significantly improve BV cure rates compared to the control group, they were more effective in restoring vaginal health post-treatment, as evidenced by better Nugent Scores for vaginal health.
- The probiotics improved intestinal microbiome diversity but weren't present in the vaginal microbiome, indicating that their benefits mainly occurred through the gut, and higher baseline levels of certain bacteria were linked to treatment failure.
Background: Exposure to environmental pollutants, including benzo[a]pyrene (BaP), has been implicated in allergic diseases and intestinal microbiota homeostasis, but the environment-microbiota-immunity triangular relationship and to what extent BaP-induced remodeling of the gut microbiota contributes to intestinal allergic inflammation remain to be established.
Objectives: We investigated the impact of BaP on intestinal allergic inflammation and examined the relationship between this effect and gut microbiota dysbiosis. We explored the potential ability of intestinal bacteria to degrade BaP and alleviate cytotoxicity as a detoxification strategy to counteract the effects of BaP exposure.
Preeclampsia (PE) is a severe placenta-related pregnancy disease that has been associated with maternal systemic inflammation and immune system disorders. However, the distribution and functional changes in immune cells of the maternal-placental interface have not been well characterized. Herein, cytometry by time-of-flight mass spectrometry (CyTOF) was used to investigate the immune atlas at the decidua, which was obtained from four PE patients and four healthy controls.
View Article and Find Full Text PDFUnlabelled: Gastrointestinal (GI) disorders are very common among children with cerebral palsy. Gut microbiota has been confirmed to maintain normal GI physiological function and further contributed to cerebral palsy through the gut-brain axis. Our study was to investigate the effect of dietary fiber combined with probiotics on functional constipated children with cerebral palsy.
View Article and Find Full Text PDFThe purpose of this study was to evaluate the effectiveness of metronidazole and oral probiotics adjunct to metronidazole in the treatment of bacterial vaginosis (BV). One hundred and twenty-six Chinese women with BV were enrolled in this parallel, controlled trial, and were randomly assigned into two study arms: the metronidazole group, which was prescribed metronidazole vaginal suppositories for 7 days, and the adjunctive probiotic group, which received GR-1 and RC-14 orally for 30 days as an adjunct to metronidazole. Clinical symptoms and Nugent scores at the initial visit, 30 days and 90 days were compared.
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