Turcz. Root Bark Improves Skin Barrier Function and Symptoms of Atopic Dermatitis in Mice.

The root bark of Turcz. has been traditionally used for the topical treatment of skin disorders like pruritus. This study was designed to investigate the inflammatory and skin barrier protective effects of in mice with calcipotriol (MC903)-induced atopic dermatitis (AD).

Decoding the Functional Interactome of Non-Model Organisms with PHILHARMONIC.

Protein-protein interaction (PPI) networks are a fundamental resource for modeling cellular and molecular function, and a large and sophisticated toolbox has been developed to leverage their structure and topological organization to predict the functional roles of under-studied genes, proteins, and pathways. However, the overwhelming majority of experimentally-determined interactions from which such networks are constructed come from a small number of well-studied model organisms. Indeed, most species lack even a single experimentally-determined interaction in these databases, much less a network to enable the analysis of cellular function, and methods for computational PPI prediction are too noisy to apply directly.

Insulin signaling and pharmacology in humans and in corals.

Once thought to be a unique capability of the Langerhans islets in the pancreas of mammals, insulin (INS) signaling is now recognized as an evolutionarily ancient function going back to prokaryotes. INS is ubiquitously present not only in humans but also in unicellular eukaryotes, fungi, worms, and . Remote homologue identification also supports the presence of INS and INS receptor in corals where the availability of glucose is largely dependent on the photosynthetic activity of the symbiotic algae.

Nonlinear Topological Mechanics in Elliptically Geared Isostatic Metamaterials.

Despite the extensive studies of topological systems, the experimental characterizations of strongly nonlinear topological phases have been lagging. To address this shortcoming, we design and build elliptically geared isostatic metamaterials. Their nonlinear topological transitions can be realized by collective soliton motions, which stem from the transition of nonlinear Berry phase.

The Anti-Inflammatory and Skin Barrier Function Recovery Effects of in Mice with Atopic Dermatitis.

: The fruit of (Turcz.) Baill. is widely used medicinally to treat coughs, asthma, exhaustion, eczema, and pruritus in Northeast Asian countries, including Korea, China, and Japan.

Analysis of optical propagation characteristics of the ultra-long period grating using RCWA.

There have been significant research and analyses on the diffraction efficiency and characteristics of spectral grating with a wavelength-scale period. However, thus far an analysis on a diffraction grating with an ultra-long pitch over several hundred times of the wavelength (>100µ) and a very deep groove over dozens of micrometers has not been performed. We analyzed the diffraction efficiency of these gratings by using the rigorous coupled-wave analysis (RCWA) method and confirmed that the RCWA analytic results correspond well to the actual experimental results on the wide-angle beam-spreading phenomenon.

High-frequency imagery to capture coral tissue (Montipora capricornis) response to environmental stress, a pilot study.

Environment stress is a major threat to the existence of coral reefs and has generated a lot of interest in the coral research community. Under the environmental stress, corals can experience tissue loss and/or the breakdown of symbiosis between the cnidarian host and its symbiotic algae causing the coral tissue to appear white as the skeleton can be seen by transparency. Image analysis is a common method used to assess tissue response under the environmental stress.

Transfer of knowledge from model organisms to evolutionarily distant non-model organisms: The coral Pocillopora damicornis membrane signaling receptome.

With the ease of gene sequencing and the technology available to study and manipulate non-model organisms, the extension of the methodological toolbox required to translate our understanding of model organisms to non-model organisms has become an urgent problem. For example, mining of large coral and their symbiont sequence data is a challenge, but also provides an opportunity for understanding functionality and evolution of these and other non-model organisms. Much more information than for any other eukaryotic species is available for humans, especially related to signal transduction and diseases.

High-efficiency SOI-based metalenses at telecommunication wavelengths.

We demonstrated silicon-on-insulator (SOI)-based high-efficiency metalenses at telecommunication wavelengths that are integrable with a standard 220 nm-thick silicon photonic chip. A negative electron-beam resist (ma-N) was placed on top of the Si nanodisk, providing vertical symmetry to realize high efficiency. A metasurface with a Si/ma-N disk array was numerically investigated to design a metalens that showed that a Si/ma-N metalens could focus the incident beam six times stronger than a Si metalens without ma-N.

Light-to-Hydrogen Improvement Based on Three-Factored Au@CeO/Gr Hierarchical Photocatalysts.

Recently, various attempts have been made for light-to-fuels conversion, often with limited performance. Herein we report active and lasting three-factored hierarchical photocatalysts consisting of plasmon Au, ceria semiconductor, and graphene conductor for hydrogen production. The Au@CeO/Gr entity (graphene outer shell thickness of 2.

Leaf-Like Origami with Bistability for Self-Adaptive Grasping Motions.

The leaf-like origami structure is inspired by geometric patterns found in nature, exhibiting unique transitions between open and closed shapes. With a bistable energy landscape, leaf-like origami is able to replicate the autonomous grasping of objects observed in biological systems such as the Venus flytrap. We show uniform grasping motions of the leaf-like origami, as well as various nonuniform grasping motions that arise from its multitransformable nature.

The Effects of tDCS with NDT on the Improvement of Motor Development in Cerebral Palsy.

We investigated the effects of transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) with neurodevelopmental treatment (NDT) on the improvement of motor development and reduction of spasticity in children with cerebral palsy (CP). Twenty-four children with CP were allocated to two groups: the tDCS + NDT group and the only NDT group, done 3 times per week for 5 weeks. The Gross Motor Function Measurement (GMFM-88) and Box and Block Test (BBT) were used to assess changes in motor development, and the Modified Ashworth Scale (MAS) was used to evaluate changes in spasticity.

Digital image processing to detect subtle motion in stony coral.

Coral reef ecosystems support significant biological activities and harbor huge diversity, but they are facing a severe crisis driven by anthropogenic activities and climate change. An important behavioral trait of the coral holobiont is coral motion, which may play an essential role in feeding, competition, reproduction, and thus survival and fitness. Therefore, characterizing coral behavior through motion analysis will aid our understanding of basic biological and physical coral functions.

Applying model approaches in non-model systems: A review and case study on coral cell culture.

Model systems approaches search for commonality in patterns underlying biological diversity and complexity led by common evolutionary paths. The success of the approach does not rest on the species chosen but on the scalability of the model and methods used to develop the model and engage research. Fine-tuning approaches to improve coral cell cultures will provide a robust platform for studying symbiosis breakdown, the calcification mechanism and its disruption, protein interactions, micronutrient transport/exchange, and the toxicity of nanoparticles, among other key biological aspects, with the added advantage of minimizing the ethical conundrum of repeated testing on ecologically threatened organisms.

Author Correction: Dial-in Topological Metamaterials Based on Bistable Stewart Platform.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Mechanical Analogue of a Majorana Bound State.

The discovery of topologically nontrivial electronic systems has opened a new age in condensed matter research. From topological insulators to topological superconductors and Weyl semimetals, it is now understood that some of the most remarkable and robust phases in electronic systems (e.g.

Origami-based impact mitigation via rarefaction solitary wave creation.

The principles underlying the art of origami paper folding can be applied to design sophisticated metamaterials with unique mechanical properties. By exploiting the flat crease patterns that determine the dynamic folding and unfolding motion of origami, we are able to design an origami-based metamaterial that can form rarefaction solitary waves. Our analytical, numerical, and experimental results demonstrate that this rarefaction solitary wave overtakes initial compressive strain waves, thereby causing the latter part of the origami structure to feel tension first instead of compression under impact.

Directional coupling of surface plasmon polaritons at complementary split-ring resonators.

We propose a complementary split-ring resonator (CSRR) for a directional coupling of surface plasmon polaritons. An air-slot split-ring in a gold film is investigated using the finite-difference time-domain method. The normally incident light couples to either a monopole or a dipole SPP depending on the polarization of light.

Direct measurement of superdiffusive energy transport in disordered granular chains.

Energy transport properties in heterogeneous materials have attracted scientific interest for more than half of a century, and they continue to offer fundamental and rich questions. One of the outstanding challenges is to extend Anderson theory for uncorrelated and fully disordered lattices in condensed-matter systems to physical settings in which additional effects compete with disorder. Here we present the first systematic experimental study of energy transport and localization properties in simultaneously disordered and nonlinear granular crystals.

Dial-in Topological Metamaterials Based on Bistable Stewart Platform.

Recently, there have been significant efforts to guide mechanical energy in structures by relying on a novel topological framework popularized by the discovery of topological insulators. Here, we propose a topological metamaterial system based on the design of the Stewart Platform, which can not only guide mechanical waves robustly in a desired path, but also can be tuned in situ to change this wave path at will. Without resorting to any active materials, the current system harnesses bistablilty in its unit cells, such that tuning can be performed simply by a dial-in action.

Origami-based tunable truss structures for non-volatile mechanical memory operation.

Origami has recently received significant interest from the scientific community as a method for designing building blocks to construct metamaterials. However, the primary focus has been placed on their kinematic applications by leveraging the compactness and auxeticity of planar origami platforms. Here, we present volumetric origami cells-specifically triangulated cylindrical origami (TCO)-with tunable stability and stiffness, and demonstrate their feasibility as non-volatile mechanical memory storage devices.

High refractive index metamaterials using corrugated metallic slots.

We report on a method for realizing high refractive index metamaterials using corrugated metallic slot structures at terahertz frequencies. The effective refractive index and peak index frequency can be controlled by varying the width of the air gap in the corrugated slot arrays. The phenomenon occurs because of the secondary resonance effect due to the fundamental inductive-capacitive resonance, which generates a red-shift of the fundamental resonance determined by twice the length of the corrugated metallic slots.