Publications by authors named "Jinkun Bae"

Article Synopsis
  • Hyperinflammation plays a key role in sepsis, impacting outcomes positively and negatively; researchers previously identified exosome-based super-repressor IκBα (Exo-srIκB) as a promising treatment.
  • In a rat model simulating polymicrobial sepsis, the study tested Exo-srIκB on different severities of sepsis and at various time points post-infection.
  • Results showed significant survival benefits with Exo-srIκB, particularly when given 6 hours post-infection in severe sepsis, along with reductions in harmful cytokines and improvements in critical blood markers.
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Previously, we have shown that mitochondrial transplantation in the sepsis model has immune modulatory effects. The mitochondrial function could have different characteristics dependent on cell types. Here, we investigated whether the effects of mitochondrial transplantation on the sepsis model could be different depending on the cell type, from which mitochondria were isolated.

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Objective: Steroids are used in cases of sepsis, especially in patients experiencing septic shock. However, clinical trials to date have reported contradictory results. Different patient endotypes and variations in the type and dose of steroid may be at fault for this discrepancy, and further investigation is warranted.

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Immune suppression is known to occur during sepsis. Endotoxin tolerance is considered a mechanism of immune suppression in sepsis. However, the timing and serial changes in endotoxin tolerance have not been fully investigated.

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Steroids are currently being used in sepsis, particularly in septic shock. However, clinical trials to date have shown contradictory results. This could be attributed to the different patient endotypes and steroid doses, which have also contributed to the inconclusive results.

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Inferior vena cava (IVC) aneurysms rarely occur. They are commonly detected incidentally since they present with mild or no symptoms. This was the first study to report a fatal case of a saccular IVC aneurysm with pulmonary embolism and cerebral infarction.

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Intra-abdominal infection (IAI) is a common and important cause of infectious mortality in intensive care units. Adequate source control and appropriate antimicrobial regimens are key in the management of IAI. In community-acquired IAI, guidelines recommend the use of different antimicrobial regimens according to severity.

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Article Synopsis
  • The study investigates the use of the tip-to-carina (TC) distance measured on chest X-rays to determine if a central venous catheter (CVC) tip is correctly positioned in the superior vena cava (SVC) and right atrium (RA) for effective monitoring.
  • Researchers conducted a retrospective cohort study involving 479 patients who had both chest X-rays and CT scans after CVC insertion, analyzing the TC distance and CVC tip positions.
  • The findings indicate that TC distance is a reliable measure for confirming CVC tip placement with significant accuracy, suggesting reference values between -6.69 to 15.61 mm for optimal positioning.
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Article Synopsis
  • Ischemic stroke is influenced by both genetic and environmental factors, with recent studies using whole-exome sequencing to identify novel variants linked to the disease.
  • Researchers analyzed specific genes, like N-methylpurine DNA glycosylase and nitrogen permease regulator-like 3, in a sample of 519 ischemic stroke patients and 417 controls.
  • They discovered significant associations between certain genetic polymorphisms and ischemic stroke, suggesting these variants could serve as clinical biomarkers for the disease's development and patient prognosis.
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Several studies have demonstrated the beneficial effect of mesenchymal stem cells (MSCs) on intracerebral hemorrhage (ICH). Enhancement of the therapeutic efficacy of MSCs in ICH is necessary, considering the diseases high association with mortality and morbidity. Various preconditioning methods to enhance the beneficial properties of MSCs have been introduced.

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Background And Purpose: MicroRNA (miRNA) expression has been examined in multiple conditions, including various cancers, neurological diseases, and cerebrovascular diseases, particularly stroke. Existing evidence indicates that miRNA biosynthesis and function play crucial roles in ischemic stroke physiology and pathology. In this study, we selected six known polymorphisms in miRNA-biogenesis genes; rs13078A>T, rs3742330A>G; rs10719T>C, rs6877842G>C; Ran GTPase () rs14035C>T; exportin 5 () rs11077A>C.

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Background: We investigated the effect of vitamin D deficiency on cardiovascular risk profiles in an Asian population with chronic kidney disease (CKD).

Methods: A total of 210 participants (62 non-dialysis CKD patients and 148 hemodialysis [HD] patients) were enrolled between December 2009 and February 2010. Vitamin D deficiency was determined using the serum 25-hydroxyvitamin D [25(OH)D] concentration.

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MicroRNAs (miRNAs or miRs) are small (19-23 nt) non-coding RNA molecules that are endogenous regulators of gene expression. Previous studies have found that some miRNAs are related to the progression of ischemia in the cerebral artery. Furthermore, a recent study found a significant association between miRNA single nucleotide polymorphisms (SNPs) and the risk of ischemic stroke.

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Objectives: To assess how the quality of metronome-guided cardiopulmonary resuscitation (CPR) was affected by the chest compression rate familiarised by training before the performance and to determine a possible mechanism for any effect shown.

Design: Prospective crossover trial of a simulated, one-person, chest-compression-only CPR.

Setting: Participants were recruited from a medical school and two paramedic schools of South Korea.

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Objective: Current guidelines for cardiopulmonary resuscitation recommend chest compressions (CC) during 50% of the duty cycle (DC) in part because of the ease with which individuals may learn to achieve it with practice. However, no consideration has been given to a possible interaction between DC and depth of CC, which has been the subject of recent study. Our aim was to determine if 50% DC is inappropriate to achieve sufficient chest compression depth for female and light rescuers.

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Stroke is the second leading cause of death in the world and in South Korea. Ischemic stroke and silent brain infarction (SBI) are complex, multifactorial diseases influenced by multiple genetic and environmental factors. Moderately elevated plasma homocysteine levels are a major risk factor for vascular diseases, including stroke and SBI.

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Objectives: Recent studies have shown that there may be an interaction between duty cycle and other factors related to the quality of chest compression. Duty cycle represents the fraction of compression phase. We aimed to investigate the effect of shorter compression phase on average chest compression depth during metronome-guided cardiopulmonary resuscitation.

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