GILT stabilizes cofilin to promote the metastasis of prostate cancer.

Gamma-interferon-induced lysosomal thiol reductase (GILT), known for catalyzing disulfide bond reduction, is involved in various physiological processes. While the involvement of GILT in the development of various tumors has been demonstrated, the mechanisms underlying its regulation in prostate cancer (PCa) are not fully understood. In the present study, we confirmed that GILT was significantly upregulated in PCa and facilitated tumor metastasis.

Deciphering the mineral code of urinary stones: A first look at zinc isotopes.

Zinc (Zn) is an essential element for all living organisms, and Zn isotopes play a key role in studying the formation of disease. Despite extensive studies on Zn isotopes in healthy and diseased human tissues, the role of Zn isotopes in urinary stones remains unexplored. This study investigates Zn isotopes in 37 urinary stones using multi-collector inductively coupled plasma mass spectrometry.

Distribution and controlling factors of dissolved inorganic carbon in urban rivers of a North China megacity: Insights from δC.

Transportation and transformation of the dissolved inorganic carbon (DIC) play a critical role in the regional carbon cycle. To clarify the natural and anthropogenic impacts on DIC, the concentration and isotopic composition of DIC (δC) in two typical urban rivers in northern China (Yongding River, YDR, and Chaobai River, CBR) were measured. Mass-balanced calculations were employed to quantify the impacts of different weathering processes.

TaFAR9 and TaFAR10 synergistically regulate fertility conversion of photo-thermo-sensitive genic male sterility lines in wheat by modulating ROS homeostasis.

Photo-thermo-sensitive genic male sterility (PTGMS), which exhibits varying fertility levels under different environmental conditions, is a crucial method for heterosis utilization in wheat. However, the mechanisms underlying fertility conversion remain unclear. In the study, three BS type PTGMS lines were analyzed to study fertility conversion characteristics.

Synergistically Constructing High-Dielectric Poly(-phenylene isophthalamide)/Silica/Cellulose Nanofiber Composite Insulation Paper through Dynamic Covalent Chemistry and Hydrogen Bonding.

The rapid advancement of modern power equipment and high-power devices has imposed increasingly stringent demands upon the mechanical and dielectric properties of electrical insulation materials. Herein, we report a poly(-phenylene isophthalamide) (PMIA) composite insulating paper with excellent dielectric breakdown strength, reliable mechanical properties, and high thermal stability. Enhanced surface activity of PMIA is achieved through surface modification, facilitating the synergistic integration of modified PMIA (MPMIA), bovine serum albumin (BSA)/silica (SiO), and cellulose nanofiber (CNF) into composite paper using dynamic covalent bonds and hydrogen bonding.

Anillin contributes to prostate cancer progression through the regulation of IGF2BP1 to promote c-Myc and MAPK signaling.

Prostate cancer (PCa), especially castration-resistant PCa, is a common and fatal disease. Anillin (ANLN) is an actin-binding protein that is involved in various malignancies, including PCa. However, the regulatory mechanism of ANLN in PCa remains unclear.

CircUBE3A(2,3,4,5) promotes adenylate-uridylate-rich binding factor 1 nuclear translocation to suppress prostate cancer metastasis.

Metastatic progression is the primary cause of mortality in prostate cancer (PCa) patients. Although circular RNAs (circRNAs) have been implicated in cancer progression and metastasis, our current understanding of their role in PCa metastasis remains limited. In this study, we identified that circUBE3A(2,3,4,5), which originated from exons 2, 3, 4 and 5 of the human ubiquitin-protein ligase E3A (UBE3A) gene, was specifically downregulated in PCa tissues and correlated with the Gleason score, bone metastasis, and D'Amico risk classification.

Effect of damming on hydrogeochemical characteristics and potential environmental risks in a large reservoir: Insights from different vertical layer sampling.

The water environment of large reservoirs is fragility due to effects from hydrological regulation of damming and anthropogenic inputs. As a critical path to quantify the natural chemical weathering and assess environmental risks, solute chemistry of river has been widely focused on. However, the complexed hydrological conditions of large reservoir affect the chemical compositions, and the significance of solute vertical geochemistry as an indicator of chemical weathering and water quality health remains explore.

Advances in the application of metallic isotopes to the identification of contaminant sources in environmental geochemistry.

The development of the economy and society makes heavy metals (HMs) pollution more and more serious. And, pollution source identification is the primary work of environmental pollution control and land planning. Notably, stable isotope technology has a high ability to distinguish pollution sources, and can better reflect the migration behavior and contribution of HMs from diverse sources, which has become a hot research tool for pollution source identification of HMs.

Improved visualization of high-dimensional data using the distance-of-distance transformation.

Dimensionality reduction tools like t-SNE and UMAP are widely used for high-dimensional data analysis. For instance, these tools are applied in biology to describe spiking patterns of neuronal populations or the genetic profiles of different cell types. Here, we show that when data include noise points that are randomly scattered within a high-dimensional space, a "scattering noise problem" occurs in the low-dimensional embedding where noise points overlap with the cluster points.

The short inverted repeats-induced circEXOC6B inhibits prostate cancer metastasis by enhancing the binding of RBMS1 and HuR.

Circular RNAs (circRNAs) are a novel class of endogenous RNAs with a covalently closed loop structure. Many circRNAs have been found to participate in cancer progression. However, the detailed generation process, functions, and related mechanisms of circRNAs in prostate cancer (PCa) remain largely unknown.

Zn isotope fractionation in laterites from Yunnan province, southwest China: Implications for the Zn cycles and its environmental impacts in (sub-) tropics.

The weathering and development of laterites can influence trace element cycling in (sub-) tropics. Zinc (Zn) is a ubiquitous trace metal that involves both abiotic and biotic processes in soils. To explore Zn behavior in laterites, Zn cycling in (sub-) tropics, and the environmental impacts, Zn isotope systematics were presented for two laterite profiles from Yunnan province, southwest China.

Deep Learning-Based Multi-Omics Integration Robustly Predicts Relapse in Prostate Cancer.

Objective: Post-operative biochemical relapse (BCR) continues to occur in a significant percentage of patients with localized prostate cancer (PCa). Current stratification methods are not adequate to identify high-risk patients. The present study exploits the ability of deep learning (DL) algorithms using the H2O package to combine multi-omics data to resolve this problem.

Multi-isotopes revealing the coastal river anthropogenic pollutants and natural material flux to ocean: Sr, C, N, S, and O isotope study.

Coastal river exports massive terrestrial materials to the adjacent marine environment with information about chemical weathering, providing critical insights on riverine flux and the potential impact on marine ecosystem. In this study, the preliminary data of dissolved strontium (Sr) and Sr/Sr in a typical coastal river in southeastern China were collected along with hydrochemistry and C, N, S, and O isotopes to discriminate the source of terrestrial weathering and the riverine flux. Sr concentrations exhibited a range of 0.

Potentially toxic elements in cascade dams-influenced river originated from Tibetan Plateau.

Rivers originated from Tibetan Plateau are of great significance due to their environmental sensibility and fragility. However, the pollution of suspended particulate matter (SPM) in these rivers is rarely reported, in particular, the potentially toxic elements (PTEs) contamination. To clarify the status, sources, behavior, and risks of PTEs in SPM, a full investigation was conducted in dams-influenced Lancangjiang River basin.

Tracing riverine sulfate source in an agricultural watershed: Constraints from stable isotopes.

The sulfate pollution in water environment gains more and more concerns in recent years. The discharge of domestic, municipal, and industrial wastewaters increases the riverine sulfate concentrations, which may cause local health and ecological problems. To better understand the sources of sulfate, this study collected water samples in a typical agricultural watershed in East Thailand.

The Dual Effect of Ionic Liquid Pretreatment on the Eucalyptus Kraft Pulp during Oxygen Delignification Process.

Oxygen delignification presents high efficiency but causes damage to cellulose, therefore leading to an undesired loss in pulp strength. The effect of ionic liquid pretreatment of [BMIM][HSO] and [TEA][HSO] on oxygen delignification of the eucalyptus kraft pulp was investigated at 10% IL loading and 10% pulp consistency, after which composition analysis, pulp and fiber characterizations, and the mechanism of lignin degradation were carried out. A possible dual effect of enhancing delignification and protecting fibers from oxidation damage occurred simultaneously.

Controlling factors of seasonal and spatial variation of riverine CO partial pressure and its implication for riverine carbon flux.

Global carbon cycle is closely related to the earth's energy budget, because CO plays an active role in the global climate change. The higher CO partial pressure (pCO) in inland water in comparison with atmosphere, causing a CO evasion from water to the air. However, the relationship between CO evasion, riverine carbon export, and hydrochemistry in watershed has remained largely unknown.

Tracing Riverine Particulate Black Carbon Sources in Xijiang River Basin: Insight from Stable Isotopic Composition and Bayesian Mixing Model.

Rivers transport abundant terrestrial carbon into the ocean, constituting a fundamental channel between terrestrial carbon pools and oceanic carbon pools. The black carbon (BC) derived from biomass and fossil fuel combustion is an important component of the riverine organic carbon flux. A recent study estimated that approximately 17 ~ 37 Tg C of BC was delivered in suspended particle phase by rivers per year.

Global, continental, and national variation in PM, O, and NO concentrations during the early 2020 COVID-19 lockdown.

Lockdowns implemented in response to COVID-19 have caused an unprecedented reduction in global economic and transport activity. In this study, variation in the concentration of health-threatening air pollutants (PM, NO, and O) pre- and post-lockdown was investigated at global, continental, and national scales. We analyzed ground-based data from >10,000 monitoring stations in 380 cities across the globe.

Major ions and δS in Jiulongjiang River water: Investigating the relationships between natural chemical weathering and human perturbations.

The chemical weathering processes become a rising concern in carbon cycling research, because it can increase carbon budgets of lateral transport by rivers and effectively sequestrate atmospheric CO. Recent studies suggest that the human perturbations can accelerate the chemical weathering, however, the processes of accelerated weathering and its potential environmental effects still remain questions. To examine the mechanism of the human-related accelerated weathering and its influences, the spatial-temporal distributions of the major ions and stable isotope compositions (δS) in Jiulongjiang River are measured.