Triphenylphosphine, iodide and -chloro-arylsulfonamides could generate amidyl radicals EDA (Electron Donor-Acceptor) complexes under visible light irradiation, and this strategy enables the synthesis of valuable δ-chloro-arylsulfonamide and -arylsulfonylpyrrolidine motifs in moderate yields. This blue LED-induced method utilizes more readily available reagents, providing advantages in terms of cost efficiency, broad substrate scope, and functional-group compatibility.
View Article and Find Full Text PDFWe report the visible-light-induced PhP/LiI-promoted intermolecular cascade trifluoromethyl radical addition/5--dig cyclization/iodination of 1,6-enynes with Togni's reagent using LiI as the iodine source without the need of the transition metal, oxidant, and base. This reaction promises to be a useful method for the preparation of trifluoromethyl-substituted and vinyl C-I bond-containing pyrrolidines and benzofuran products with good regioselectivity and functional-group tolerance under ambient conditions.
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