The construction of an efficient and durable oxygen evolution reaction (OER) electrocatalyst through a simple synthesis strategy is crucial for the hydrogen produced from seawater splitting. However, achieving this goal remains a great challenge. Herein, the synthesis of amorphous Fe-doped nickel phosphate (Fe-NiPO) as a high-performance OER electrocatalysts for alkaline freshwater/seawater splitting is presented using a straightforward co-precipitation method at room-temperature.
View Article and Find Full Text PDFBackground: Breast cancer is the most common malignancy among women worldwide, characterized by complex molecular and cellular heterogeneity. Despite advances in diagnosis and treatment, there is an urgent need to identify reliable biomarkers and therapeutic targets to improve early detection and personalized therapy. The OAS (2'-5'-oligoadenylate synthetase) family genes, known for their roles in antiviral immunity, have emerged as potential regulators in cancer biology.
View Article and Find Full Text PDFA novel approach is proposed leveraging surface-enhanced Raman spectroscopy (SERS) combined with machine learning (ML) techniques, principal component analysis (PCA)-centroid displacement-based nearest neighbor (CDNN). This label-free approach can identify slight abnormalities between SERS spectra of gastric lesions at different stages, offering a promising avenue for detection and prevention of precancerous lesion of gastric cancer (PLGC). The agaric-shaped nanoarray substrate was prepared using gas-liquid interface self-assembly and reactive ion etching (RIE) technology to measure SERS spectra of serum from mice model with gastric lesions at different stages, and then a SERS spectral recognition model was trained and constructed using the PCA-CDNN algorithm.
View Article and Find Full Text PDFSecond-generation antipsychotics are widely used to treat schizophrenia but their use could induce metabolic dysfunction. To balance efficacy and side effects, various guidelines recommend the use of therapeutic drug monitoring. Given the controversial relationship between olanzapine serum concentration and metabolic dysfunction, its use in clinical practice is still debated.
View Article and Find Full Text PDF2H-NbSe single crystal flake (ca. 2 × 2 × 0.5 mm in size) by chemical vapor transport is employed as the precursor for a top-down preparation of NbSe micro/nanoparticles by two kinds of processes, i.
View Article and Find Full Text PDFBackground: This study aimed to investigate the influence of CYP2D6 polymorphisms on risperidone plasma concentrations in patients with schizophrenia. Based on pharmacogenomics, we examined whether plasma concentration of risperidone is associated with clinical response and adverse side-effects.
Methods: We recruited patients with chronic schizophrenia who were then treated with risperidone.
Rational design and construction of high-efficiency and low-cost non-noble metal-based electrocatalysts for the hydrogen evolution reaction (HER) is critical for future renewable energy systems. Herein, a multi-channel V-doped CoP (MC-V-CoP) hollow nanofiber is fabricated via electrospinning and a subsequent oxidation/phosphorization process. The formation of a multi-channel hollow structure and V doping can enlarge the exposure of active sites, facilitate the electron transfer and tune the electronic structure of the active sites, resulting in the enhancement of the HER performance.
View Article and Find Full Text PDFThermal behavior of biological apatite is the object of several studies. Crystal size, carbonate content, phase composition, and other parameters change during annealing up to 900 °C in biological minerals with apatite structure. The way these parameters change reflects the specific properties of the initial bioapatite.
View Article and Find Full Text PDFOrthodenticle homolog 1 (OTX1) has previously been revealed to be tightly associated with the development and progression of several human tumors. However, the functional roles and underlying molecular mechanisms of OTX1 in gastric cancer (GC) remain poorly understood. In the present study, we observed that OTX1 was highly expressed in GC tissues compared with adjacent non‑tumor tissues based on a large cohort of samples from The Cancer Genome Atlas (TCGA) database.
View Article and Find Full Text PDFIdiopathic segmental infraction of the greater omentum (ISIGO) is a rare cause of acute abdomen. One of the main symptoms is right-side abdominal pain, while its etiology is still unclear. Until now, ISIGO simultaneously with spontaneous splenic rupture (SSR) has not been reported.
View Article and Find Full Text PDFUsing velocity map ion imaging, the photodissociation of chlorobromomethane (CH2BrCl) at 233-234 nm has been studied. The total translational energy distributions and the anisotropy parameters have been determined from the ion images of the photofragments Br ((2)P1/2) (denoted as Br(*)) and Br ((2)P3/2) (denoted as Br) for the dominant CH2BrCl + hv → CH2Cl + Br(*) and CH2BrCl + hv → CH2Cl + Br channels. Using an impulsive model invoking angular momentum conservation, the vibrational energy distributions of the chloromethyl radicals have been derived from the total translational energy distributions for the two channels.
View Article and Find Full Text PDFTwo precursors of ribbon-like anhydrous dicalcium phosphate (DCPA) and calcium phosphate fibres were successfully synthesized at 85 °C through a simple and mild pathway from Ca(NO(3))(2)·4H(2)O and (NH(4))(2)HPO(4) upon the hydrolysis of urea. Different molar concentrations of urea resulted in different precursors, including precursor I (DCPA phase) and precursor II (calcium phosphate with DCPA, octacalcium phosphate (OCP) and hydroxyapatite (HAp) phase). By immersing the two precursors in ammonium hydroxide solution (pH = 12), the transformation from precursors to hydroxyapatite could be achieved.
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