CT assessment of liver fat fraction and abdominal fat composition can predict postoperative liver metastasis of colorectal cancer.

Objective: The aim of this study is to investigate the clinical value of liver fat fraction assessed by CT(CT-LFF) and abdominal fat components. We focus on predicting liver metastasis (LM) after colorectal cancer (CRC) surgery.

Methods: Clinical and imaging data from 79 patients who underwent radical CRC surgery between January 2019 and December 2021 were retrospectively collected.

Advancements in NMN biotherapy and research updates in the field of digestive system diseases.

Nicotinamide mononucleotide (NMN), a crucial intermediate in NAD + synthesis, can rapidly transform into NAD + within the body after ingestion. NMN plays a pivotal role in several important biological processes, including energy metabolism, cellular aging, circadian rhythm regulation, DNA repair, chromatin remodeling, immunity, and inflammation. NMN has emerged as a key focus of research in the fields of biomedicine, health care, and food science.

Enhanced delivery of CRISPR/Cas9 system based on biomimetic nanoparticles for hepatitis B virus therapy.

The persistent presence of covalently closed circular DNA (cccDNA) in hepatocyte nuclei poses a significant obstacle to achieving a comprehensive cure for hepatitis B virus (HBV). Current applications of CRISPR/Cas9 for targeting and eliminating cccDNA have been confined to in vitro studies due to challenges in stable cccDNA expression in animal models and the limited non-immunogenicity of delivery systems. This study addresses these limitations by introducing a novel non-viral gene delivery system utilizing Gemini Surfactant (GS).

Paclitaxel-induced Immune Dysfunction and Activation of Transcription Factor AP-1 Facilitate Hepatitis B Virus Replication.

Background And Aims: Hepatitis B virus (HBV) reactivation is commonly observed in individuals with chronic HBV infection undergoing antineoplastic drug therapy. Paclitaxel (PTX) treatment has been identified as a potential trigger for HBV reactivation. This study aimed to uncover the mechanisms of PTX-induced HBV reactivation and , which may inform new strategies for HBV antiviral treatment.

The underlying mechanism and targeted therapy strategy of miRNAs cross-regulating EMT process through multiple signaling pathways in hepatocellular carcinoma.

The consistent notion holds that hepatocellular carcinoma (HCC) initiation, progression, and clinical treatment failure treatment failure are affected by the accumulation of various genetic and epigenetic alterations. MicroRNAs (miRNAs) play an irreplaceable role in a variety of physiological and pathological states. meanwhile, epithelial-mesenchymal transition (EMT) is a crucial biological process that controls the development of HCC.

Activin and Hepatocyte Growth Factor Promotes Colorectal Cancer Stemness and Metastasis through FOXM1/SOX2/CXCR4 Signaling.

Background/aims: Cancer stem cells (CSCs) are believed to drive tumor development and metastasis. Activin and hepatocyte growth factor (HGF) are important cytokines with the ability to induce cancer stemness. However, the effect of activin and HGF combination treatment on CSCs is still unclear.

Numerical Simulation Study on Spatial Diffusion Behavior of Non-Point Source Fugitive Dust under Different Enclosure Heights.

Non-point source fugitive dust produced during municipal road construction is one of the main ambient air pollutants gravely threatening the life and health of construction workers and residents around construction areas. In this study, a gas-solid two-phase flow model is used to simulate the diffusion behavior of non-point source dust with different enclosure heights under wind loads. Moreover, the inhibitory effect of the enclosure on the diffusion of non-point source dust from construction to residential areas is analyzed.

GATA4 Forms a Positive Feedback Loop with CDX2 to Transactivate MUC2 in Bile Acids-Induced Gastric Intestinal Metaplasia.

Background/aims: Gastric intestinal metaplasia (GIM), a common precancerous lesion of gastric cancer, can be caused by bile acid reflux. GATA binding protein 4 (GATA4) is an intestinal transcription factor involved in the progression of gastric cancer. However, the expression and regulation of GATA4 in GIM has not been clarified.

Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD).

Non-alcoholic fatty liver disease (NAFLD) is a series of diseases, involving excessive lipid deposition in the liver and is often accompanied by obesity, diabetes, dyslipidemia, abnormal blood pressure, and other metabolic disorders. In order to more accurately reflect its pathogenesis, an international consensus renamed NAFLD in 2020 as metabolic (dysfunction) associated with fatty liver disease (MAFLD). The changes in diet and lifestyle are recognized the non-drug treatment strategies; however, due to the complex pathogenesis of NAFLD, the current drug therapies are mainly focused on its pathogenic factors, key links of pathogenesis, and related metabolic disorders as targets.

Sequential Treatment with Activin and Hepatocyte Growth Factor Induces FOXM1 to Promote Colorectal Cancer Liver Metastasis.

Background: Cancer stem cells (CSCs) are involved in liver metastasis in colorectal cancer (CRC). Activin and hepatocyte growth factor (HGF) are important regulators of stem cell properties. This study was performed to explore the effect of activin and HGF on CRC invasion and metastasis.

Mechanical Properties of Polyvinyl Alcohol Fiber-Reinforced Cementitious Composites after High-Temperature Exposure.

The mechanical properties of cementitious composites before and after exposure to high temperature are affected by calcium-silicate-hydrate (C-S-H) gels. To evaluate the effects of high temperature, plyvinyl alcohol (PVA) fiber content, and the cooling method on properties of cementitious composites, physical, mechanical, and microscopic tests were performed in this study. The target temperatures were 25, 100, 200, 300, 400, 600, and 800 °C.

Fractional derivative modeling for sediment suspension in ice-covered channels.

Characterizing the anomalous diffusion behavior of sediment transport is a key factor in calculating sediment concentration. This study attempts to seek an equation that captures the nonlocal movement feature of the transport of an ensemble of sediment particles on ice-covered channels with a steady uniform flow field. Given that the fractional advection-dispersion equation with a noninteger order on the space term is nonlocal and able to describe the long-distance transport, a mathematical model with the Caputo fractional derivative is proposed to estimate the vertical diffusion of suspended sediment particles in the ice-covered channel.

The Evaluation of Construction Dust Diffusion and Sedimentation Using Wind Tunnel Experiment.

A large quantity of particulate matter is generated during construction of civil engineering projects, which has a negative effect on the atmosphere and environment. In order to explore the concentration, distribution and diffusion of particulate matters generated from construction dust with different moisture contents, a wind tunnel experiment was conducted, and the effects of wind speed and moisture content on the inhibition rate, drifting distance and suppression percentage of particulate matters were investigated. The results show that the peak concentration decreases with the increase in moisture content, compared with dry dust; the peak concentrations for 1%, 2% and 3% moisture content are reduced by 37.

Effect of Municipal Solid Waste Incineration Fly Ash on the Mechanical Properties and Microstructure of Geopolymer Concrete.

Geopolymers are environmentally friendly materials made from industrial solid waste with high silicon and aluminum contents, and municipal solid waste incineration fly ash (MFA) contains active ingredients such as Si, Al and Ca. According to this fact, a green and low-carbon geopolymer concrete was prepared using MFA as a partial replacement for metakaolin in this study. The mechanical properties of the MFA geopolymer concrete (MFA-GPC) were investigated through a series of experiments, including a compressive strength test, splitting tensile strength test, elastic modulus test and three-point bending fracture test.

Early-Age Mechanical Characteristics and Microstructure of Concrete Containing Mineral Admixtures under the Environment of Low Humidity and Large Temperature Variation.

The application of concrete containing mineral admixtures was attempted in Northwest China in this study, where the environment has the characteristics of low humidity and large temperature variation. The harsh environment was simulated by using an environmental chamber in the laboratory and four types of concrete were prepared, including ordinary concrete and three kinds of mineral admixture concretes with different contents of fly ash and blast-furnace slag. These concretes were cured in the environmental chamber according to the real curing conditions during construction.

Clinical and Demographic Characteristics of Cluster Cases and Sporadic Cases of Coronavirus Disease 2019 (COVID-19) in 141 Patients in the Main District of Chongqing, China, Between January and February 2020.

BACKGROUND In December 2019, an outbreak of coronavirus disease 2019 (COVID-19), due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), occurred in Wuhan, China. Patients with COVID-19 were also identified in Chongqing. This study aimed to investigate the clinical and demographic characteristics of cluster cases and sporadic cases of COVID-19 in 141 patients in the main district of Chongqing during one month, between January and February 2020.

Epidemiological and clinical characteristics of 136 cases of COVID-19 in main district of Chongqing.

Background: We did a comprehensive exploration of the epidemiological and clinical characteristics of 136 patients with confirmed COVID-19 in main district of Chongqing which was adjacent to the west of Hubei province.

Methods: This study was conducted on 136 patients with COVID-19 in main district of Chongqing from Jan 25 to Feb 20, 2020. Data of patients included demographic, epidemiological, clinical features, chest radiographs of imported cases, local cases, second-generation cases and third-generation cases.

Experimental Study on Freezing and Thawing Cycles of Shrinkage-Compensating Concrete with Double Expansive Agents.

The freezing and thawing of construction concrete is becoming an increasingly important structural challenge. In this study, a shrinkage-compensating concrete based on a double expansive admixture was developed and its frost resistance was assessed through rapid freezing and thawing cycling. The frost resistance of the concrete was derived through the measurement and calculation of the relative dynamic modulus of elasticity (RDME) and the mass loss rate (MLR), and the freezing- and thawing-cycle microstructures and products of concretes with different expansive agents were analyzed using scanning electron microscopy (SEM).

Modification Effects of Carbon Nanotube Dispersion on the Mechanical Properties, Pore Structure, and Microstructure of Cement Mortar.

Carbon nanotubes (CNTs) are very effective in improving the performance of cement-based materials. Mechanical properties and pore structure were investigated for cement mortar with CNTs. Meanwhile, the composite morphology of CNT-cement material and the evolution of hydration products were observed by scanning electron microscope (SEM), and the quantitative relationship between mechanical properties and pore structure was analyzed.

Effect of Dry-Wet Ratio on Properties of Concrete Under Sulfate Attack.

In order to explore the drying-wetting cycle test method of concrete under sulfate accelerating erosion, the influence of dry-wet time ratio on concrete sulfate erosion was studied. Under the condition of 7 days for one cycle, five different dry-wet time ratios were designed: 1:3, 1:1, 3:1, 5:1, and 10:1. The basic properties such as compressive strength, splitting tensile strength and dynamic elastic modulus of concrete were tested.

[Effect of Fertilizers on Cadmium Uptake and Accumulation by Sunflowers].

A pot experiment was conducted to assess the phytoextraction potential for cadmium (Cd) of three types of sunflowers (edible, ornamental, and oil sunflowers) and the effects of the application of N, NP, and NPK fertilizers on Cd uptake of the three plants using Cd-contaminated soils collected from northern China. The results showed that fertilization could significantly increase the biomass, aboveground Cd concentrations and accumulation of ornamental and oil sunflowers, and the effect of NPK fertilizer was significantly better than those of other treatments. Cd concentrations of the aboveground parts of edible, ornamental, and oil sunflowers were 6.