PRR11 is a prognostic biomarker and correlates with immune infiltrates in bladder urothelial carcinoma.

Abnormal proline-rich protein 11 (PRR11) expression is associated with various tumors. However, there are few reports concerning PRR11 with prognostic risk, immune infiltration, or immunotherapy of bladder urothelial carcinoma (BLCA). This study is based on online databases, such as Oncomine, GEPIA, HPA, LinkedOmics, TIMER, ESTIMATE and TISIDB, and BLCA data downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus, we employed an array of bioinformatics methods to explore the potential oncogenic roles of PRR11, including analyzing the relationship between PRR11 and prognosis, tumor mutational burden (TMB), microsatellite instability, and immune cell infiltration in BLCA.

Polysaccharide Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in Mice via Activation of the NLRP3 Inflammasome.

polysaccharide (IOP), the primary constituent of the parasitic fungus , has anti-tumor, anti-inflammatory, anti-oxidation effects. However, the roles of IOP on colitis-associated cancer (CAC) are still unclear. Herein, we tested the efficacy of IOP using a mouse model of CAC induced by azoxymethane and dextran sulfate sodium (AOM/DSS).

Effects of exogenous starch on the structural-thermal properties of gluten in wheat with HMW-GS variations at Glu-D1 locus.

To further understand the gluten-starch interactions in dough, this study investigated the effects of exogenous starch on the structural-thermal properties of gluten via reconstituting Xinong 836 starch with gluten from near-isogenic lines HMW-D1a (Dy12) and HMW-D1p (Dx2 + Dy12) according to the following proportions (gluten/starch): 9/91 (G09), 12/88 (G12), 15/85 (G15), and two controls, where G00 and G01 represent the original and self-reconstituted flours, respectively. Adding exogenous starch significantly improved the dough strength for the reconstituted flours containing gluten from HMW-D1a and HMW-D1p, especially those with HMW-D1a. When the ratios of gluten to starch were 15/85 and 12/88 in the HMW-D1a and HMW-D1p reconstituted flours, respectively, the concentrations of free sulfhydryl groups were minimized in the flour, and thus more glutenin polymers were formed.

Inonotus obliquus polysaccharide ameliorates dextran sulphate sodium induced colitis involving modulation of Th1/Th2 and Th17/Treg balance.

Inflammatory bowel disease (IBD) is an intestinal chronic inflammatory disease, and is related to imbalance of CD4T subsets. However, the current treatments of chronic colitis are not ideal and have potential side effects. Therefore, more effective and safer biologically active substances which are extracted from natural plants have been widely concerned.