Quantitative vascular feature-based multimodality prediction model for multi-origin malignant cervical lymphadenopathy.

Background: The precise prediction of multi-origin malignant cervical lymphadenopathy is limited by the low inter-reader reproducibility of imaging interpretation, and a quantitative method to improve this aspect is lacking. This study aimed to develop and validate an artificial intelligence framework integrating quantitative vascular features for assessing cervical lymphadenopathy and explore its utility among radiologists.

Methods: For this retrospective study, a total of 21,298 ultrasound images of 10,649 cervical lymph nodes (LNs) from 10,386 patients and 2366 images of 1183 LNs from 1151 patients at the Sun Yat-sen University Cancer Center between January 2011 and July 2022 were used for model development and internal testing, respectively.

Development and validation of an interpretable model integrating multimodal information for improving ovarian cancer diagnosis.

Ovarian cancer, a group of heterogeneous diseases, presents with extensive characteristics with the highest mortality among gynecological malignancies. Accurate and early diagnosis of ovarian cancer is of great significance. Here, we present OvcaFinder, an interpretable model constructed from ultrasound images-based deep learning (DL) predictions, Ovarian-Adnexal Reporting and Data System scores from radiologists, and routine clinical variables.

Development and validation of ultrasound-based radiomics model to predict germline BRCA mutations in patients with breast cancer.

Background: Identifying breast cancer (BC) patients with germline breast cancer susceptibility gene (gBRCA) mutation is important. The current criteria for germline testing for BC remain controversial. This study aimed to develop a nomogram incorporating ultrasound radiomic features and clinicopathological factors to predict gBRCA mutations in patients with BC.