Enhanced denoising for weak signal preservation in structured illumination microscopy.

Structured illumination microscopy (SIM) is a powerful super-resolution technology in biological science because of its fast imaging speed, low phototoxicity, and full-field imaging. Despite this, SIM is hampered by out-of-focus background noise, which can obscure weak fluorescence signals and render them unrecognizable. Previous denoising algorithms tended to eliminate the noise along with the weak signals, causing a decrease in image quality.

Research on healthcare data sharing in the context of digital platforms considering the risks of data breaches.

Background: Within China's healthcare landscape, the sharing of medical data has emerged as a pivotal force propelling advancements in the insurance sector and enhancing patient engagement with healthcare services. However, medical institutions often exhibit reluctance toward data sharing due to apprehensions regarding data security and privacy safeguards. To navigate this conundrum, our research introduces and empirically validates a model grounded in evolutionary game theory, offering a robust theoretical framework and actionable strategies for facilitating healthcare data sharing while harmonizing the dual imperatives of data utility and privacy preservation.

Enhancing Upper Limb Function and Motor Skills Post-Stroke Through an Upper Limb Rehabilitation Robot.

Cerebrovascular accidents, commonly known as strokes, represent a prevalent neurological event leading to significant upper limb disabilities, thereby profoundly affecting individuals' activities of daily living and diminishing their quality of life. Traditional rehabilitation methods for upper limb recovery post-stroke are often hindered by limitations, including therapist and patient fatigue, reliance on singular training methodologies, and lack of sustained motivation. Addressing these challenges, this study introduces an upper limb rehabilitation robot, which uses intelligent feedback motion control to improve therapeutic outcomes.

Efficacy and safety of low-dose interleukin 2 in the treatment of moderate-to-severe bullous pemphigoid: A single center perspective-controlled trial.

Background: Regulatory T cells (Tregs) are reduced in the peripheral blood and skin lesions of patients with bullous pemphigoid (BP). Low-dose interleukin 2 (IL-2) therapy can stimulate Tregs specifically, suggesting potential for the treatment of BP.

Objective: To evaluate the response to low-dose IL-2 therapy in the treatment of moderate-to-severe BP.

Relationship Between the Gut Microbiota and Neurological Deficits in Patients With Cerebral Ischemic Stroke.

Objective: The aim of the paper was to investigate the composition and structure of intestinal flora in patients with cerebral ischemic stroke (CIS), and to investigate the relationship between gut microbiota (GM) and different levels of stroke severity.

Methods: In this study, 47 CIS patients (16 mild, 21 moderate, and 10 severe) and 15 healthy controls were included. General information, clinical data, and behavioral scores of the enrolled subjects were collected.

Effects of electroacupuncture on the PI3K/Akt/CREB signaling pathway and hippocampal neuronal apoptosis in diabetic cognitive impairment rats.

Objectives: To observe the effects of electroacupuncture (EA) on the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/cAMP response element binding protein (CREB) signaling pathway-related proteins and hippocampal neuron apoptosis in diabetic cognitive impairment (DCI) rats, and to explore the mechanisms of EA in treating DCI.

Methods: Adult male SD rats were randomly divided into normal, model, and EA groups, with 12 rats in each group. The animal model of DCI was replicated using a high-fat, high-sugar diet combined with low-dose streptozotocin.

Risk factors for dysphagia in patients with acute and chronic ischemic stroke: A retrospective cohort study.

Background: Dysphagia is a common and clinically significant complication of ischemic stroke. The prevalence and risk factors for dysphagia may vary at different stages following an ischemic stroke.

Methods: This study included patients with acute and chronic ischemic stroke who were treated at the Department of Rehabilitation, First Affiliated Hospital, Zhejiang University School of Medicine from 2019 to 2022.

Cognitive Function and Upper Limb Rehabilitation Training Post-Stroke Using a Digital Occupational Training System.

Stroke rehabilitation often requires frequent and intensive therapy to improve functional recovery. Virtual reality (VR) technology has shown the potential to meet these demands by providing engaging and motivating therapy options. The digital occupational training system is a VR application that utilizes cutting-edge technologies, including multi-touch screens, virtual reality, and human-computer interaction, to offer diverse training techniques for advanced cognitive capacity and hand-eye coordination abilities.

Deep Multi-Exposure Image Fusion for Dynamic Scenes.

Recently, learning-based multi-exposure fusion (MEF) methods have made significant improvements. However, these methods mainly focus on static scenes and are prone to generate ghosting artifacts when tackling a more common scenario, i.e.

Dithionite promoted microbial dechlorination of hexachlorobenzene while goethite further accelerated abiotic degradation by sulfidation in paddy soil.

It is of great scientific and practical importance to explore the mechanisms of accelerated degradation of Hexachlorobenzene (HCB) in soil. Both iron oxide and dithionite may promote the reductive dechlorination of HCB, but their effects on the microbial community and the biotic and abiotic mechanisms behind it remain unclear. This study investigated the effects of goethite, dithionite, and their interaction on microbial community composition and structure, and their potential contribution to HCB dechlorination in a paddy soil to reveal the underlying mechanism.

Ferroptosis as a potential new therapeutic target for diabetes and its complications.

Diabetes is a complex metabolic disease. In recent years, diabetes and its chronic complications have become a health hotspot of global concern. It is very important to find promising therapeutic targets and directions.

Deep learning-enabled anti-ambient light approach for fringe projection profilometry.

Achieving high-quality surface profiles under strong ambient light is challenging in fringe projection profilometry (FPP) since ambient light inhibits functional illumination from exhibiting sinusoidal stripes with high quantization levels. Conventionally, large-step phase shifting approaches are presented to enhance the anti-interference capability of FPP, but the image acquisition process in these approaches is highly time-consuming. Inspired by the promising performance of deep learning in optical metrology, we propose a deep learning-enabled anti-ambient light (DLAL) approach that can help FPP extract phase distributions from a single fringe image exposed to unbalanced lighting.

The Influence of Online Social Value Co-creation Activity on Consumer Purchase Intention: An Experimental Study.

In recent years, an increasing number of online social value co-creation activities are conducted by companies in their marketing campaigns. A question is that whether these activities that take social responsibilities could help enterprises improve marketing performance. Drawing from social interaction theory, this study explores the causal effect of online social value co-creation on consumer purchase intention through three experiments.

Comparison of Essential Oils of Thunb. from Different Processing Methods and Harvest Seasons Based on GC-MS and Chemometric Analysis.

Houttuyniae Herba (HH) refers to the dried aerial part of Thunb. (DHC) or the fresh whole grass of Thunb. (FHC), where DHC are harvested in summer and FHC around the year.

Biochar-Polylactic Acid Composite Accelerated Reductive Dechlorination of Hexachlorobenzene in Paddy Soils under Neutral pH Condition.

In order to clarify the effect of biochar-polylactic acid (PLA) composite on reductive dechlorination of HCB in paddy soils, an anaerobic incubation experiment was conducted with four treatments of Sterile control, Control, Biochar, and Biochar-PLA in Hydragric Acrisols (Ac) and Gleyi-Stagnic Anthrosols (An). The results showed that in Ac, biochar addition significantly promoted HCB degradation during the whole incubation period, but biochar-PLA composite inhibited HCB dechlorination due to the low soil pH in the early period and then accelerated HCB degradation while soil pH climbed to nearly neutral. The dechlorination rate of HCB in An was: Biochar-PLA > Biochar > Control > Sterilization control.

3D Reconstruction of human bones based on dictionary learning.

An effective method for reconstructing a 3D model of human bones from computed tomography (CT) image data based on dictionary learning is proposed. In this study, the dictionary comprises the vertices of triangular meshes, and the sparse coefficient matrix indicates the connectivity information. For better reconstruction performance, we proposed a balance coefficient between the approximation and regularisation terms and a method for optimisation.

Relationship between plasma carotenoids, fruit and vegetable intake, and plasma extracellular superoxide dismutase activity in women: different in health and disease?

Abstract Exogenous antioxidants may influence endogenous antioxidant enzyme activity. We observed in healthy women (n = 95) that higher plasma α-carotene, β-carotene, β-cryptoxanthin, sum of plasma carotenoids, and fruit and vegetable intake were associated with lower plasma extracellular-superoxide dismutase activity. In women with a history of cardiovascular disease, diabetes, or cancer (n = 62), we observed no associations.