DNA nanovaccines derived from ferritin-modified glycogens for targeted delivery to immature dendritic cells and for promotion of Th1 cell differentiation.

DNA vaccines have emerged as a powerful approach for advanced cancer therapy. Despite the development of various delivery systems to enhance the immunogenicity of DNA vaccines, many still face challenges such as limited DNA condensation, rapid degradation in vivo and insufficient targeting to lymph nodes (LNs). Synthetic dendrimers with modifiable surfaces exhibit high efficiency in DNA condensation, but their synthesis is extremely complex.

Cancer vaccine designed from homologous ferritin-based fusion protein with enhanced DC-T cell crosstalk for durable adaptive immunity against tumors.

Peptide vaccines based on tumor antigens face the challenges of rapid clearance of peptides, low immunogenicity, and immune suppressive tumor microenvironment. However, the traditional solution mainly uses exogenous substances as adjuvants or carriers to enhance innate immune responses, but excessive inflammation can damage adaptive immunity. In the current study, we propose a straightforward novel nanovaccine strategy by employing homologous human ferritin light chain for minimized innate immunity and dendritic cell (DC) targeting, the cationic KALA peptide for enhanced cellular uptake, and suppressor of cytokine signaling 1 (SOCS1) siRNA for modulating DC activity.

Entrepreneurship education and self-efficacy among Chinese college students mediated by harmonious passion and moderated by parental psychological control.

Despite the rapid development of entrepreneurship education among college students, limited research has examined the hindering role of Chinese parents in this process under the socio-cultural context of China. To address this gap, a quantitative study was conducted to investigate how entrepreneurship education enhances college students' entrepreneurial self-efficacy (ESE) and the impact of Chinese parental psychological control (PPC). Data were collected from 1,411 college students using structured questionnaires and analyzed using hierarchical regression.

Ferroptosis exacerbates the clonal deletion of virus-specific exhausted CD8 T cells.

During chronic infection or tumorigenesis, persistent antigen stimulation contributes to the exhaustion of CD8 T cells. Nevertheless, exhausted CD8 T (T) cells still preserve certain effector function, and maintaining a reservoir of exhausted cells is of vital importance for virus elimination and tumor eradiation. Despite considerable work interrogating the rejuvenation of T cells, mechanisms underpinning the clonal deletion of T cells remain largely unexplored over the past decade.

Entrepreneurial fear of failure among college students: A scoping review of literature from 2010 to 2023.

Entrepreneurial fear of failure (EFoF) is a psychological barrier to college entrepreneurship. Current research on EFoF among college students is at an emerging stage, and relevant evidence, such as the factors influencing EFoF, remains unclear and unsystematic. Most EFoF studies treat college students as general entrepreneurs, neglecting their unique social identities and situational contexts that influence their EFoF, such as parents and education.

TCL1A-expressing B cells are critical for tertiary lymphoid structure formation and the prognosis of oral squamous cell carcinoma.

Background: Oral squamous cell carcinoma (OSCC) is a malignant tumor with a poor prognosis. Traditional treatments have limited effectiveness. Regulation of the immune response represents a promising new approach for OSCC treatment.

Generation of -tdTomato Knock-in Mice for Specific Cerebrovascular Endothelial Cell Targeting.

The cerebrovascular endothelial cells with distinct characteristics line cerebrovascular blood vessels and are the fundamental structure of the blood-brain barrier, which is important for the development and homeostatic maintenance of the central nervous system. Cre-LoxP system-based spatial gene manipulation in mice is critical for investigating the physiological functions of key factors or signaling pathways in cerebrovascular endothelial cells. However, there is a lack of Cre recombinase mouse lines that specifically target cerebrovascular endothelial cells.

Boosting the synergism between cancer ferroptosis and immunotherapy via targeted stimuli-responsive liposomes.

Both ferroptotic therapy and immunotherapy have been widely employed in cancer treatment. However, ferroptotic cell death fails to induce dendritic cells maturation, which limits the therapeutic outcome of ferroptotic cancer therapy. To address this, the current work reports a tailored liposome to establish a positive loop between ferroptotic therapy and immunotherapy.

High glucose levels delay the senescence of stem cells from human exfoliated deciduous teeth by suppressing autophagy.

Objective: In this study, we aimed to investigate the effects of varying glucose concentrations on the proliferation and senescence of stem cells from human exfoliated deciduous teeth (SHED) compared to human bone marrow-derived mesenchymal stem cells (hBMSC), and preliminarily clarify the difference of glucose metabolism between SHED and hBMSC.

Design: We cultured SHED and hBMSC in the presence of increasing glucose concentrations to study the role of glucose in cell viability, proliferation, and senescence. Gene expression related to the stemness of mesenchymal stem cells was evaluated using real-time quantitative reverse transcription-polymerase chain reaction.

Parenting and parent-child home practice during the COVID-19 pandemic: a case in central China.

The current study aims to explore parents' perceptions of parenting and parent-child activities at home with children aged 3-6 during the pandemic in China. A parenting survey was conducted to investigate parental role, age, educational background, work productivity, and different parenting categories during the lockdown period. We also examined the experiences of young children's participation in extracurricular activities before and after the stay-at-home policy was implemented as well as their activities with parents during the lockdown period.

Chondroitin sulfate modified calcium phosphate nanoparticles for efficient transfection via caveolin-mediated endocytosis.

Efficient transfection remains a challenge for gene delivery in both cell biological scientific research and gene therapeutic fields. Existing transfection strategies rarely pay attention to altering the endocytosis pathway of nanocarriers for transfection efficiency improvement. In this work, we innovatively postulated that calcium phosphate nanoparticles coated with glycosaminoglycan could be internalized by cells mainly through caveolin-mediated endocytosis pathway allowing genes to bypass lysosome route, and hence enhance the transfection efficiency.

Low income is associated with impaired jaw function via anxiety and depression in patients with temporomandibular disorders.

Objective: The association between jaw function and income in patients with temporomandibular disorders (TMDs) remain unclear. The aim of this study was to explore this association and its relationship with anxiety and depression.

Subjects And Methods: A total of 451 TMD patients, including 361 males and 90 females, participated in this study.

Virtual interdisciplinary collaboration during the COVID-19 pandemic: pain and joy in an international joint university.

Background: The COVID-19 pandemic has brought interdisciplinary academics and research students many uncertainties and challenges in adapting to new communication styles. Compared with other academics in the same field, interdisciplinary academics might face more challenges in transitioning from traditional face-to-face communication to virtual communication.

Objective: This study aimed to explore the pain and joy of using Western and Chinese localized communication channels in experienced interdisciplinary academics ( = 10) and young research students ( = 14) during the pandemic.

Astragaloside IV for Heart Failure: Preclinical Evidence and Possible Mechanisms, A Systematic Review and Meta-Analysis.

Objective: To explore the cardioprotective effects of astragaloside IV (AS-IV) in heart failure (HF).

Methods: PubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, Wanfang Database, Chinese Bio-medical Literature and Retrieval System (SinoMed), China Science and Technology Journal Database (VIP), and China National Knowledge Infrastructure (CNKI) were searched from inception to November 1, 2021 for animal experiments to explore AS-IV in treating HF in rats or mice. The left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD), left ventricular weight-to-body weight (LVW/BW) and B-type brain natriuretic peptide (BNP) were recorded.

Anti-inflammatory Therapy Progress in Major Adverse Cardiac Events after PCI: Chinese and Western Medicine.

Acute coronary syndrome (ACS) is one of the leading causes of death in cardiovascular disease. Percutaneous coronary intervention (PCI) is an important method for the treatment of coronary heart disease (CHD), and it has greatly reduced the mortality of ACS patients since its application. However, a series of new problems may occur after PCI, such as in-stent restenosis, no-reflow phenomenon, in-stent neoatherosclerosis, late stent thrombosis, myocardial ischemia-reperfusion injury, and malignant ventricular arrhythmias, which result in the occurrence of major adverse cardiac events (MACE) that seriously reduce the postoperative benefit for patients.

The associations between social environment and adolescents' psychosomatic health: An ecological perspective.

Objectives: It has been known that social environments are associated with adolescents' health. However, the complex relationship between diverse types of social environments and adolescents' psychosomatic heath remained unclear. Thus, using an ecological perspective, the current study aimed to examine the associations between social environment and adolescents' psychosomatic health.

Health literacy and health outcomes among older patients suffering from chronic diseases: A moderated mediation model.

Introduction: Aging brings with an increased risk of chronic diseases among older adults, which could affect health outcomes. Evidence has showed that health literacy is associated with health outcomes. However, limited studies explore the underlying mechanism between health literacy and health outcomes.

Parental Knowledge, Preference and Needs of Child-Rearing Family Programmes: A Case in Chinese Inner Mongolia Minority Region.

Core parenting knowledge is critical for enhancing children's physical and mental development throughout the early stages of life, and it is essential to understand parents' preferences and needs in acquiring core parenting knowledge. In particular, with the launch of the Family Education Law in China, parents, community workers, and early childhood (EC) teachers gather together to engage in scientific and evidence-based programmes. However, Chinese historical and cultural factors, such as parents' authority, family structure, child rearing, and non-scientific programme support, affect the improvement of parents' knowledge and understanding of child-rearing programmes.

Social Media Web 2.0 Tools Adoption in Language and Literacy Development in Early Years: A Scoping Review.

Social media tools are increasingly used in child's language and literacy development in early years. However, few researchers shed light on effectiveness and the practice that the EC professionals and teachers have adopted in ECE settings and other related contexts. This scoping review synthesized and evaluated the literature on social media integration in language and literacy development in ECE in the last decade, to provide a clearer picture on what social media tools were used, how they were used, and whether they were effective.

Oral magnesium sulphate administration in rats with minimal hepatic encephalopathy: NMR-based metabolic characterization of the brain.

Objective: To investigate the metabolic changes in rats with minimal hepatic encephalopathy (MHE) treated with oral magnesium sulphate administration.

Materials And Methods: A total of 30 Sprague-Dawley rats were divided into a control group and MHE group (further divided into an MHE group and an MHE-Mg group treated with oral administration of 124 mg/kg/day magnesium sulphate). Morris water maze (MWM), Y maze and narrow beam walking (NBW) were used to evaluate cognitive and motor functions.

Comparing the Efficacy of Two School-Based Approaches of Neurocognitive Training for Enhancing Executive Functions.

Neurocognitive training has been shown to improve a range of cognitive/executive functions and behavior in children. Delivering this training in a school context may enhance its ecological validity and improve training outcomes. The current study examined the efficacy of two school-based neurocognitive training approaches for enhancing executive functions (EF) in typically developing children: neurocognitive training with no teacher positive feedback (NCT), and neurocognitive training with teacher positive feedback (NCT-TPF).

Exploring social media technologies for novice EFL school teachers to collaborate and communicate: A case in the Czech Republic.

With an increasing number of international schools, traditional EFL teaching methods may not satisfy students' needs. This study aims to investigate perceptions of social media technologies (e.g.

Metformin carbon nanodots promote odontoblastic differentiation of dental pulp stem cells by pathway of autophagy.

Human dental pulp stem cells (hDPSCs) have been a focus of pulp regeneration research because of their excellent odontogenic potential and availability. Applying the odontoblastic differentiation of hDPSCs to tooth regeneration has been challenging. Metformin-based carbon nanodots (MCDs) were synthesized and characterized to investigate their effects on odontoblastic hDPSC differentiation and the underlying mechanism.