Mining Non-Redundant Co-Location Patterns.

Co-location pattern mining refers to discovering neighboring relationships of spatial features distributed in geographic space. With the rapid growth of spatial datasets, the usefulness of co-location patterns is strongly limited by the large number of discovered patterns containing multiple redundancies. To address this problem, in this article, we propose a novel approach for discovering the super participation index-closed (SPI-closed) co-location patterns which are a newly proposed lossless condensed representation of co-location patterns by considering distributions of the spatial instances.

Synthesis and biological evaluation of 3-(4-fluorophenyl)-1H-pyrazole derivatives as androgen receptor antagonists.

A novel series of 3-(4-fluorophenyl)-1H-pyrazole derivatives were synthesized and evaluated for their antiproliferative activity against two prostate cancer cell lines (LNCaP and PC-3) and androgen receptor target gene prostate-specific antigen (PSA) inhibitory activity in LNCaP cells. Several compounds showed potent antiproliferative activity against LNCaP cells and showed a promising PSA downregulation rate. Among these, compound 10e selectively inhibited LNCaP cell growth with an IC50 value of 18 μmol/l and showed a PSA downregulation rate of 46%, which was better than the lead compound T3.

Construction of β-mannosidic bonds via gold(I)-catalyzed glycosylations with mannopyranosyl ortho-hexynylbenzoates and its application in synthesis of acremomannolipin A.

A mild and convenient protocol for direct synthesis of β-mannosides has been developed. Glycosylation of 4,6-O-benzylidene-protected mannosyl ortho-hexynylbenzoates with various alcohol acceptors catalyzed by gold(I) complex proceeded smoothly at 0 °C to room temperature and afforded the corresponding β-mannoside in high yield and satisfactory stereoselectivity. This reaction was applied to the total synthesis of acremomannolipin A and its analogue.

A versatile cyclic 2,2'-azobenzenophane with a functional handle and its polymers: efficient synthesis and effect of topological structure on chiroptical properties.

Two novel cyclic azobenzenophanes (SC, RC) with functional handles have been synthesized efficiently by a Glaser coupling reaction. Through a Suzuki coupling reaction, alternating ring/linear polymers with rigid (conjugated)/flexible (unconjugated) bridges were obtained from the resultant cyclic azobenzenophanes. The optical activities of linear, cyclic, and macromolecular binaphethyl-azobenzene derivatives were investigated by UV/Vis and circular dichroism (CD) spectra and the time-dependent (TD)-DFT method.

Cyclic amphiphilic random copolymers bearing azobenzene side chains: facile synthesis and topological effects on self-assembly and photoisomerization.

In this article, well-defined cyclic amphiphilic random copolymers bearing azobenzene side chains and pendent carboxyl moieties, cyclic-P(BHMEm -co-AAn )s, are synthesized by combining atom transfer radical polymerization (ATRP) with Cu(I)-catalyzed azide/alkyne cycloaddition (CuAAC) "click" reaction and selective hydrolysis of tert-butyl ester. Successful synthesis of the cyclic-P(BHMEm -co-AAn )s is fully characterized and verified via conventional gel permeation chromatography, triple detection gel permeation chromatography, nuclear magnetic resonance, Fourier transform infrared, and matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. The cyclic topology induces profound effects on the glass transition temperatures, self-assembly behavior, and photoresponsive performance of the copolymers compared with their linear counterparts.