Poly (β-amino esters)/Mobil Composition of Matter 41-mediated delivery of siIL-1β alleviates deep vein thrombosis in rat hind limbs.

Deep vein thrombosis (DVT) is a major cause of cardiovascular disease-related deaths worldwide and is considered a thrombotic inflammatory disorder. IL-1β, as a key promoter of venous thrombus inflammation, is a potential target for DVT treatment. Constructing a nanocarrier system for intracellular delivery of siIL-1β to silence IL-1β may be an effective strategy for alleviating DVT.

Genome-Wide Identification and Characterization of Gene Family in Foxtail Millet ( L.).

The genes encode signaling peptides that play important roles in various developmental and physiological processes. However, the systematic identification and characterization of genes in foxtail millet ( L.) remain limited.

AI diagnosis of Bethesda category IV thyroid nodules.

Thyroid nodules are a common disease, and fine needle aspiration cytology (FNAC) is the primary method to assess their malignancy. For the diagnosis of follicular thyroid nodules, however, FNAC has limitations. FNAC can classify them only as Bethesda IV nodules, leaving their exact malignant status and pathological type undetermined.

Deep Class-Incremental Learning From Decentralized Data.

In this article, we focus on a new and challenging decentralized machine learning paradigm in which there are continuous inflows of data to be addressed and the data are stored in multiple repositories. We initiate the study of data-decentralized class-incremental learning (DCIL) by making the following contributions. First, we formulate the DCIL problem and develop the experimental protocol.

Genomic Architecture of Yield Performance of an Elite Rice Hybrid Revealed by its Derived Recombinant Inbred Line and Their Backcross Hybrid Populations.

Background: Since its development and wide adoption in China, hybrid rice has reached the yield plateau for more than three decades. To understand the genetic basis of heterosis in rice and accelerate hybrid rice breeding, the yield performances of the elite rice hybrid, Quan-you-si-miao (QYSM) were genetically dissected by whole-genome sequencing, large-scale phenotyping of 1061 recombined inbred lines (RILs) and 1061 backcross F (BCF) hybrids derived from QYSM's parents across three environments and gene-based analyses.

Results: Genome-wide scanning of 13,847 segregating genes between the parents and linkage mapping based on 855 bins across the rice genome and phenotyping experiments across three environments resulted in identification of large numbers of genes, 639 main-effect QTLs (M-QTLs) and 2736 epistatic QTLs with significant additive or heterotic effects on the trait performances of the combined population consisting of RILs and BCF hybrids, most of which were environment-specific.

A Bayesian Hierarchical Spatial Model to Correct for Misreporting in Count Data: Application to State-Level COVID-19 Data in the United States.

The COVID-19 pandemic that began at the end of 2019 has caused hundreds of millions of infections and millions of deaths worldwide. COVID-19 posed a threat to human health and profoundly impacted the global economy and people's lifestyles. The United States is one of the countries severely affected by the disease.

Micromechanical force promotes aortic valvular calcification.

Objective: Calcified aortic valvular disease is known as an inflammation-related process related to force. The purpose of this study was to determine whether micromechanical force could induce valve calcification of porcine valvular interstitial cells and to examine the role of integrin αvβ3 in valvular calcification by using a novel method: magnetic twisting cytometry.

Methods: Porcine valvular interstitial cells were cultured in vitro, and micromechanical force was applied to porcine valvular interstitial cells using magnetic twisting cytometry.

Alternating magnetic field mitigates NO emission during the aerobic composting of chicken manure.

Nitrous oxide (NO) emission is an environmental problem related to composting. Recently, the electric field-assisted aerobic composting process has been found to be effective for enhancing compost maturity and mitigating NO emission. However, the insertion of electrodes into the compost pile causes electrode erosion and inconvenience in practical operation.

An unknown mass on the cardiac surface with huge coronary aneurysm and fistula: A case report.

Cardiac mass is rare in the clinic and can be primary or secondary. It is quite rare to find a mass only on the cardiac surface. Today we report a patient with a cardiac mass grown on the cardiac surface and also had a coronary aneurysm combined a coronary fistula, pathology examination showed that the mass was not a tumor but an aneurysm with thrombosis.

Linking Electronic Transport through a Spin Crossover Thin Film to the Molecular Spin State Using X-ray Absorption Spectroscopy Operando Techniques.

One promising route toward encoding information is to utilize the two stable electronic states of a spin crossover molecule. Although this property is clearly manifested in transport across single molecule junctions, evidence linking charge transport across a solid-state device to the molecular film's spin state has thus far remained indirect. To establish this link, we deploy materials-centric and device-centric operando experiments involving X-ray absorption spectroscopy.

Abrupt Switching of Crystal Fields during Formation of Molecular Contacts.

Magnetic molecules have the potential to be used as building blocks for bits in quantum computers. The spin states of the magnetic ion in the molecule can be represented by the effective spin Hamiltonian describing the zero field splitting (ZFS) of the magnetic states. We determined the ZFS of mechanically flexible metal-chelate molecules (Co, Ni, and Cu as metal ions) adsorbed on CuN/Cu(100) by inelastic tunneling spectroscopy at temperatures down to 30 mK.

The ability to choose can increase satiation.

The ability to choose should let people create more enjoyable experiences. However, in a set of 5 studies, people who chose repeatedly during ongoing consumption exhibited a greater drop in enjoyment compared with those who received a series of random selections from the same set of liked stimuli. Process evidence indicated that choosing increased satiation because it triggered overall reflections on the repetitive nature of the ongoing consumption experience.

Single-molecule magnet behavior in 2,2'-bipyrimidine-bridged dilanthanide complexes.

A series of 2,2'-bipyrimidine-bridged dinuclear lanthanide complexes with the general formula [Ln(tmhd)3]2bpm (tmhd = 2,2,6,6-tetramethyl-3,5-heptanedionate, bpm = 2,2'-bipyrimidine, Ln = Gd(III), 1; Tb(III), 2; Dy(III), 3; Ho(III), 4 and Er(III), 5) has been synthesized and characterized. Sublimation of [Tb(tmhd)3]2bpm onto a Au(111) surface leads to the formation of a homogeneous film with hexagonal pattern, which was studied by scanning tunneling microscopy (STM). The bulk magnetic properties of all complexes have been studied comprehensively.

Sub-monolayer film growth of a volatile lanthanide complex on metallic surfaces.

We deposited a volatile lanthanide complex, tris(2,2,6,6-tetramethyl-3,5-heptanedionato)terbium(III), onto metal surfaces of Cu(111), Ag(111) and Au(111) in vacuum and observed well-ordered sub-monolayer films with low temperature (5 K) scanning tunneling microscopy. The films show a distorted three-fold symmetry with a commensurate structure. Scanning tunneling spectroscopy reveals molecular orbitals delocalized on the ligands of the molecule.

Exchange bias and room-temperature magnetic order in molecular layers.

Molecular semiconductors may exhibit antiferromagnetic correlations well below room temperature. Although inorganic antiferromagnetic layers may exchange bias single-molecule magnets, the reciprocal effect of an antiferromagnetic molecular layer magnetically pinning an inorganic ferromagnetic layer through exchange bias has so far not been observed. We report on the magnetic interplay, extending beyond the interface, between a cobalt ferromagnetic layer and a paramagnetic organic manganese phthalocyanine (MnPc) layer.

Visualization of a ferromagnetic metallic edge state in manganite strips.

Recently, broken symmetry effect induced edge states in two-dimensional electronic systems have attracted great attention. However, whether edge states may exist in strongly correlated oxides is not yet known. In this work, using perovskite manganites as prototype systems, we demonstrate that edge states do exist in strongly correlated oxides.