Publications by Jini Yang | LitMetric

Publications by authors named "Jini Yang"

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Chronic Stress-Induced and Tumor Derived SP1 Exosomes Polarizing IL-1β Neutrophils to Increase Lung Metastasis of Breast Cancer.

Leyi Zhang Jun Pan Meijun Wang Jini Yang Sangsang Zhu

Adv Sci (Weinh)

January 2025

Article Synopsis

Chronic stress enhances the release and alters the contents of tumor-derived exosomes (TDEs) in breast cancer, suggesting a link between stress and cancer progression.
In experiments with tumor-bearing mice, it was found that chronic stress boosts the secretion of TDEs and facilitates lung metastasis through interactions with pulmonary neutrophils.
The study reveals that TDEs increase SP1 levels, which leads to increased IL-1β secretion from neutrophils, further promoting cancer spread via the TLR4-NFκβ pathway.

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